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QuickView for DNMT1 (gene)


Gene Symbol:
DNMT1 Homo sapiens Homo sapiens
Full name:
DNA (cytosine-5-)-methyltransferase 1
Synonyms:
DNMT, AIM, DNA (cytosine-5)-methyltransferase 1, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 1, DNA methyltransferase HsaI, DNA MTase HsaI, CXXC finger protein 9, CXXC-type zinc finger protein 9, CXXC9, HSN1E, m.HsaI, FLJ16293, MGC104992, MCMT
Genomic Location:
Chr 19: 10105022-10166811
Description:
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefS...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Unknown transcription factor binding site geneset 6 ETS1 binding site geneset 1 Unknown transcription factor binding site geneset 8 GABPB1 binding site geneset 1 Unknown transcription factor binding site geneset 57 Unknown transcription factor binding site geneset 58 Unknown transcription factor binding site geneset 60 E2F1 binding site geneset 1 E2F1 binding site geneset 3 Unknown transcription factor binding site geneset 67
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 19
19p13.2


Transcripts Names
NM_001379
NM_001130823



GO Molecular Function

sequence-specific DNA binding | transferase activity, transferring one-carbon groups | cation binding | nucleic acid binding | S-adenosylmethionine-dependent methyltransferase activity | nucleotide binding | binding | catalytic activity | DNA binding | ion binding | organic cyclic compound binding | nucleoside phosphate binding | protein binding | zinc ion binding | transcription factor binding | DNA-methyltransferase activity | transferase activity | transition metal ion binding | DNA (cytosine-5-)-methyltransferase activity | methyltransferase activity | methyl-CpG binding | metal ion binding | heterocyclic compound binding | small molecule binding | RNA binding

GO Biological Process

RNA metabolic process | regulation of biological process | positive regulation of cellular component organization | regulation of biosynthetic process | nucleic acid metabolic process | DNA modification | negative regulation of cellular process | cellular macromolecule metabolic process | transferase activity, transferring one-carbon groups | regulation of protein modification process | regulation of organelle organization | cellular process | regulation of gene expression, epigenetic | macromolecule methylation | negative regulation of cellular component organization | chromatin organization | regulation of histone H3-K9 methylation | regulation of histone modification | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | negative regulation of cellular metabolic process | negative regulation of histone methylation | regulation of cellular process | cellular component organization or biogenesis | gene silencing | regulation of metabolic process | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organic nitrogen | cellular aromatic compound metabolic process | cellular component organization | negative regulation of protein modification process | regulation of histone methylation | response to stimulus | response to chemical stimulus | positive regulation of protein metabolic process | regulation of macromolecule biosynthetic process | regulation of cell proliferation | macromolecule biosynthetic process | cellular nitrogen compound metabolic process | response to endogenous stimulus | negative regulation of metabolic process | cellular biosynthetic process | macromolecule modification | DNA alkylation | catalytic activity | nitrogen compound metabolic process | positive regulation of organelle organization | response to amino acid stimulus | negative regulation of RNA metabolic process | positive regulation of chromosome organization | regulation of gene expression | negative regulation of histone H3-K9 methylation | methylation | positive regulation of cellular metabolic process | regulation of macromolecule metabolic process | regulation of nitrogen compound metabolic process | negative regulation of nitrogen compound metabolic process | regulation of transcription from RNA polymerase II promoter | DNA methylation | DNA methylation on cytosine | cellular response to amine stimulus | chromatin modification | biological regulation | biosynthetic process | regulation of primary metabolic process | regulation of cellular protein metabolic process | negative regulation of histone modification | positive regulation of macromolecule metabolic process | cellular response to amino acid stimulus | positive regulation of biological process | regulation of cellular macromolecule biosynthetic process | negative regulation of nucleobase-containing compound metabolic process | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | regulation of protein metabolic process | regulation of histone H3-K4 methylation | regulation of RNA metabolic process | cellular component organization at cellular level | positive regulation of protein modification process | response to organic substance | DNA-methyltransferase activity | C-5 methylation of cytosine | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | DNA metabolic process | response to amine stimulus | metabolic process | primary metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-dependent | cellular response to stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of organelle organization | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | cellular response to endogenous stimulus | cellular response to acid | transferase activity | regulation of chromosome organization | negative regulation of biological process | response to acid | transcription, DNA-dependent | maintenance of DNA methylation | negative regulation of protein metabolic process | negative regulation of chromosome organization | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | cellular component organization or biogenesis at cellular level | cellular macromolecule biosynthetic process | DNA (cytosine-5-)-methyltransferase activity | methyltransferase activity | organelle organization | negative regulation of cellular biosynthetic process | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | response to organic nitrogen | heterocycle metabolic process | negative regulation of cellular macromolecule biosynthetic process | positive regulation of metabolic process | chromosome organization | positive regulation of histone methylation | cellular metabolic process | cellular response to organic substance | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | chromosome, centromeric region | cell | replication fork | intracellular non-membrane-bounded organelle | intracellular organelle | chromatin | organelle part | intracellular organelle part | centromeric heterochromatin | chromosomal part | cell part | membrane-bounded organelle | heterochromatin | nucleus | organelle | non-membrane-bounded organelle | intracellular part | intracellular