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QuickView for Calcium Acetate (compound)


PubChem
Name: calcium acetate
PubChem Compound ID: 517040
Molecular formula: C4H6CaO4
Molecular weight: 158.166 g/mol
Synonyms:
Acetic acid, calcium salt, hydrate
DrugBank
Identification
Name: calcium acetate
Name (isomeric): DB00258
Drug Type: small molecule
Synonyms:
Gray acetate; Grey acetate; Calcium acetate hydrate; Lime pyrolignite; Calcium acetate monohydrate; Procalamine; Lime acetate; Gray acetate of lime; Acetic acid, calcium salt; Pyrolignite of lime.
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Brand: PhosLo Gelcaps, Niacet calcium acetate tech, Calac, Teltozan, Sorbo-calcion, Sorbo-calcian, PhosLo
Brand name mixture:
Medi-Kool Pak(Aluminum Sulfate + Arnica + Boric Acid + Calcium Acetate + Camphor + Menthol + Methyl Salicylate + Tannic Acid), Thc Complex #66(Aconite + Barium Carbonate + Belladonna + Bryonia + Calcium Acetate + Oyster Shells + Phytolacca Decandra + Poison Ivy + Sulfur), Anti Stress(Calcium Acetate + Folic Acid + Magnesium Chloride + Menadione ...
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Category: Antihyperphosphatemics, Chelating Agents
CAS number: 62-54-4
Pharmacology
Indication: Calcium acetate is one of a number of calcium salts used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.
Pharmacology:
Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention lea...
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Mechanism of Action: Calcium acetate and other calcium salts are phosphate binders. They work by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.
Absorption: 40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration.
Route of elimination: Calcium acetate when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces.
Toxicity: Oral, rat: LD50 = 4280 mg/kg. Symptoms of overdose include mild hypercalcemia (constipation; loss of appetite; nausea and vomiting), and severe hypercalcemia (confusion; full or partial loss of consciousness; incoherent speech).
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
ClodronateCalcium Salts may decrease the serum concentration of Bisphosphonate Derivatives such as clodronate. Avoid administration of oral calcium supplements within 2 hours before or after tiludronate/clodronate/etidronate.
LiotrixCalcium salts such as calcium acetate may diminish the therapeutic effect of thyroid products such as liotrix. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
CiprofloxacinCalcium salts such as calcium acetate may decrease the absorption of quinolone antibiotics such as ciprofloxacin. Of concern only with oral administration of both agents. Interactions can be minimized by administering oral quinolone at least 2 hours before, or 6 hours after, the dose of an oral calcium supplement. Monitor for decreased therapeutic effects of oral quinolones if administered with oral calcium supplements.
DoxycyclineCalcium salts such as calcium acetate may decrease the serum concentration of tetracycline derivatives such as doxycycline. In general, the coadministration of oral calcium salts and oral tetracycline derivatives should be avoided. Interactions may be able to be minimized by administering oral calcium preparations several hours before or after the dose of the oral tetracycline derivatives. Even with dose separation, therapy may still be compromised. Monitor for decreased therapeutic effect of oral tetracycline derivatives.
Calcium ChlorideCalcium salts may enhance the adverse/toxic effect of calcium acetate. Concurrent use of other calcium salts with calcium acetate should be avoided when possible. This combination is particularly dangerous in patients with other risk factors for hypercalcemia, such as those with end-stage renal disease.
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Targets