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QuickView for CYP3A4 (gene)


Gene Symbol:
CYP3A4 Homo sapiens Homo sapiens
Full name:
cytochrome P450, family 3, subfamily A, polypeptide 4
Synonyms:
cytochrome P450 3A3, cytochrome P450 3A4, cytochrome P450 HLp, cytochrome P450 NF-25, cytochrome P450, family 3, subfamily A, polypeptide 4, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, cytochrome P450-PCN1, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, albendazole monooxygenase, albendazole sulfoxidase, CP33, CP34, MGC126680, P450-III, steroid inducible, P450C3, P450PCN1, NF-25, nifedipine oxidase, taurochenodeoxycholate 6-alpha-hydroxylase, quinine 3-monooxygenase, glucocorticoid-inducible P450, HLP
Genomic Location:
Chr 7: 99192540-99219744
Description:
This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Gallus gallus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7q21.1





GO Molecular Function

vitamin D 24-hydroxylase activity | quinine 3-monooxygenase activity | cation binding | vitamin D3 25-hydroxylase activity | enzyme binding | steroid hydroxylase activity | lipid binding | albendazole monooxygenase activity | iron ion binding | binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | electron carrier activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | oxidoreductase activity, acting on CH or CH2 groups | vitamin D 25-hydroxylase activity | testosterone 6-beta-hydroxylase activity | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | tetrapyrrole binding | oxygen binding | protein binding | caffeine oxidase activity | transition metal ion binding | taurochenodeoxycholate 6alpha-hydroxylase activity | heme binding | steroid binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity

GO Biological Process

molting cycle | cellular hormone metabolic process | vitamin D 24-hydroxylase activity | regulation of biological quality | response to drug | cellular process | quinine 3-monooxygenase activity | alkaloid metabolic process | exogen | vitamin D3 25-hydroxylase activity | cellular response to chemical stimulus | tissue development | xenobiotic metabolic process | catabolic process | steroid hydroxylase activity | organic cyclic compound metabolic process | albendazole monooxygenase activity | cellular lipid metabolic process | response to stimulus | response to chemical stimulus | cellular response to xenobiotic stimulus | hair follicle maturation | androgen metabolic process | cellular nitrogen compound metabolic process | cellular catabolic process | drug catabolic process | catalytic activity | alkaloid catabolic process | system development | nitrogen compound metabolic process | multicellular organismal development | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | steroid catabolic process | lipid metabolic process | regulation of hormone levels | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | fat-soluble vitamin metabolic process | oxidoreductase activity, acting on CH or CH2 groups | single-organism process | small molecule metabolic process | exogenous drug catabolic process | vitamin D 25-hydroxylase activity | biological regulation | testosterone 6-beta-hydroxylase activity | terpenoid metabolic process | epidermis development | response to xenobiotic stimulus | molting cycle process | oxidative demethylation | cellular nitrogen compound catabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | anatomical structure maturation | organic cyclic compound catabolic process | drug metabolic process | monoterpenoid metabolic process | caffeine oxidase activity | hair cycle | vitamin metabolic process | anatomical structure development | metabolic process | primary metabolic process | developmental maturation | oxidation-reduction process | hair cycle process | cellular response to stimulus | lipid catabolic process | organic substance metabolic process | organ development | steroid metabolic process | taurochenodeoxycholate 6alpha-hydroxylase activity | hormone metabolic process | isoprenoid metabolic process | developmental process | single-multicellular organism process | heterocycle metabolic process | demethylation | cellular metabolic process | oxidoreductase activity | vitamin D metabolic process | hair follicle development | multicellular organismal process

GO Cellular Component

endoplasmic reticulum part | integral to membrane | intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic to membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | organelle part | intracellular organelle part | membrane part | cell part | membrane-bounded organelle | organelle | cytoplasmic part | cell surface | intracellular part | intracellular | membrane