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QuickView for CYP2E1 (gene)


Gene Symbol:
CYP2E1 Homo sapiens Homo sapiens
Full name:
cytochrome P450, family 2, subfamily E, polypeptide 1
Synonyms:
cytochrome P450 2E1, cytochrome P450, family 2, subfamily E, polypeptide 1, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1, cytochrome P450-J, CYP2E, CYPIIE1, CPE1, 4-nitrophenol 2-hydroxylase, xenobiotic monooxygenase, microsomal monooxygenase, P450-J, P450C2E, OTTHUMP00000020813, OTTHUMP00000046571, flavoprotein-linked monooxygenase
Genomic Location:
Chr 10: 135190857-135202610
Description:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 10
10q24.3-qter


Transcripts Names
NM_000773
Protein Names
Q9UK47
Q5VZD5
P05181



GO Molecular Function

cation binding | enzyme binding | iron ion binding | binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | electron carrier activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | tetrapyrrole binding | oxygen binding | protein binding | transition metal ion binding | heme binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity

GO Biological Process

cellular process | cellular response to chemical stimulus | xenobiotic metabolic process | organic cyclic compound metabolic process | cellular lipid metabolic process | response to stimulus | response to chemical stimulus | cellular response to xenobiotic stimulus | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | small molecule metabolic process | terpenoid metabolic process | response to xenobiotic stimulus | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | drug metabolic process | monoterpenoid metabolic process | metabolic process | primary metabolic process | oxidation-reduction process | cellular response to stimulus | organic substance metabolic process | steroid metabolic process | isoprenoid metabolic process | heterocycle metabolic process | cellular metabolic process | oxidoreductase activity

GO Cellular Component

endoplasmic reticulum part | intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | organelle part | intracellular organelle part | membrane part | cell part | membrane-bounded organelle | organelle | cytoplasmic part | intracellular part | intracellular | membrane