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QuickView for CYP2D6 (gene)


Gene Symbol:
CYP2D6 Homo sapiens Homo sapiens
Full name:
cytochrome P450, family 2, subfamily D, polypeptide 6
Synonyms:
cytochrome P450 2D6, cytochrome P450, family 2, subfamily D, polypeptide 6, cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2, cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2, cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6, cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1, cytochrome P450-DB1, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2D@, CYP2DL1, CYPIID6, debrisoquine 4-hydroxylase, CPD6, P450-DB1, P450C2D, P450DB1, microsomal monooxygenase, MGC120389, MGC120390, flavoprotein-linked monooxygenase, xenobiotic monooxygenase, RP4-669P10.2
Genomic Location:
Chr 22: 40852445-40856827
Description:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescri...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 22
22q13.1


Transcripts Names
NM_000106
NM_001025161
Protein Names
Q5Y7H2
Q6NXU8
P10635
C1ID52



GO Molecular Function

cation binding | iron ion binding | binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | electron carrier activity | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | tetrapyrrole binding | transition metal ion binding | heme binding | drug binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | aromatase activity

GO Biological Process

regulation of biological process | negative regulation of cellular process | cellular process | regulation of cellular organohalogen metabolic process | alkaloid metabolic process | cellular response to chemical stimulus | negative regulation of cellular metabolic process | regulation of binding | phenylpropanoid metabolic process | regulation of cellular process | regulation of metabolic process | xenobiotic metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular lipid metabolic process | response to stimulus | response to chemical stimulus | cellular response to xenobiotic stimulus | cellular nitrogen compound metabolic process | negative regulation of cellular organofluorine metabolic process | negative regulation of metabolic process | cellular catabolic process | drug catabolic process | catalytic activity | alkaloid catabolic process | nitrogen compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | small molecule metabolic process | negative regulation of binding | biological regulation | negative regulation of cellular organohalogen metabolic process | terpenoid metabolic process | response to xenobiotic stimulus | oxidative demethylation | regulation of cellular metabolic process | cellular nitrogen compound catabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | drug metabolic process | monoterpenoid metabolic process | metabolic process | primary metabolic process | oxidation-reduction process | cellular response to stimulus | organic substance metabolic process | secondary metabolic process | negative regulation of biological process | steroid metabolic process | coumarin metabolic process | negative regulation of molecular function | regulation of molecular function | isoprenoid metabolic process | isoquinoline alkaloid metabolic process | regulation of cellular organofluorine metabolic process | heterocycle metabolic process | demethylation | cellular metabolic process | oxidoreductase activity | aromatase activity

GO Cellular Component

endoplasmic reticulum part | intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | organelle part | intracellular organelle part | mitochondrion | membrane part | cell part | membrane-bounded organelle | organelle | cytoplasmic part | intracellular part | intracellular | membrane