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QuickView for CYP2C9 (gene)


Gene Symbol:
CYP2C9 Homo sapiens Homo sapiens
Full name:
cytochrome P450, family 2, subfamily C, polypeptide 9
Synonyms:
xenobiotic monooxygenase, RP11-208C17.6, flavoprotein-linked monooxygenase, P450 MP-4, P450 PB-1, P450IIC9, MGC88320, microsomal monooxygenase, OTTHUMP00000020135, MGC149605, CPC9, CYP2C, CYP2C10, CYPIIC9, cytochrome P-450 S-mephenytoin 4-hydroxylase, cytochrome P-450MP, cytochrome P450 2C9, cytochrome P450 PB-1, cytochrome P450, family 2, subfamily C, polypeptide 9, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9, cytochrome p4502C9
Genomic Location:
Chr 10: 96688430-96739137
Description:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is know...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 10
10q24


Transcripts Names
NM_000771
Protein Names
P11713
Q5VX92
P11712
Q16756
Q16872



GO Molecular Function

(S)-limonene 6-monooxygenase activity | cation binding | (S)-limonene 7-monooxygenase activity | steroid hydroxylase activity | iron ion binding | limonene monooxygenase activity | binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | electron carrier activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | oxidoreductase activity, acting on CH or CH2 groups | ion binding | organic cyclic compound binding | tetrapyrrole binding | caffeine oxidase activity | transition metal ion binding | heme binding | drug binding | (R)-limonene 6-monooxygenase activity | metal ion binding | heterocyclic compound binding | oxidoreductase activity

GO Biological Process

molting cycle | (S)-limonene 6-monooxygenase activity | response to drug | cellular process | exogen | (S)-limonene 7-monooxygenase activity | urea metabolic process | cellular response to chemical stimulus | tissue development | xenobiotic metabolic process | catabolic process | steroid hydroxylase activity | organic cyclic compound metabolic process | cellular lipid metabolic process | response to stimulus | oxoacid metabolic process | monocarboxylic acid metabolic process | response to chemical stimulus | cellular response to xenobiotic stimulus | limonene monooxygenase activity | hair follicle maturation | cellular nitrogen compound metabolic process | cellular catabolic process | drug catabolic process | catalytic activity | system development | nitrogen compound metabolic process | multicellular organismal development | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | lipid metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | oxidoreductase activity, acting on CH or CH2 groups | single-organism process | small molecule metabolic process | cellular amide metabolic process | exogenous drug catabolic process | cellular ketone metabolic process | terpenoid metabolic process | epidermis development | response to xenobiotic stimulus | molting cycle process | oxidative demethylation | anatomical structure maturation | nitrogen cycle metabolic process | drug metabolic process | carboxylic acid metabolic process | monoterpenoid metabolic process | caffeine oxidase activity | hair cycle | anatomical structure development | metabolic process | primary metabolic process | developmental maturation | oxidation-reduction process | hair cycle process | cellular response to stimulus | organic substance metabolic process | organ development | steroid metabolic process | organic acid metabolic process | isoprenoid metabolic process | developmental process | (R)-limonene 6-monooxygenase activity | single-multicellular organism process | demethylation | cellular metabolic process | oxidoreductase activity | hair follicle development | multicellular organismal process

GO Cellular Component

endoplasmic reticulum part | intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | organelle part | intracellular organelle part | membrane part | cell part | membrane-bounded organelle | organelle | cytoplasmic part | intracellular part | intracellular | membrane