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QuickView for CYP2C8 (gene)


Gene Symbol:
CYP2C8 Homo sapiens Homo sapiens
Full name:
cytochrome P450, family 2, subfamily C, polypeptide 8
Synonyms:
OTTHUMP00000020134, microsomal monooxygenase, MP-12/MP-20, P450 form 1, P450 MP-12/MP-20, flavoprotein-linked monooxygenase, cytochrome P450 2C8, cytochrome P450 form 1, cytochrome P450 IIC2, cytochrome P450 MP-12, cytochrome P450 MP-20, cytochrome P450, family 2, subfamily C, polypeptide 8, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8, CYPIIC8, CPC8, s-mephenytoin 4-hydroxylase, xenobiotic monooxygenase
Genomic Location:
Chr 10: 96786519-96819244
Description:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 10
10q23.33





GO Molecular Function

cation binding | iron ion binding | binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | electron carrier activity | oxidoreductase activity, acting on CH or CH2 groups | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | tetrapyrrole binding | caffeine oxidase activity | transition metal ion binding | heme binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | aromatase activity

GO Biological Process

molting cycle | response to drug | cellular process | exogen | cellular response to chemical stimulus | tissue development | xenobiotic metabolic process | catabolic process | response to stimulus | response to chemical stimulus | cellular response to xenobiotic stimulus | hair follicle maturation | cellular catabolic process | drug catabolic process | catalytic activity | system development | multicellular organismal development | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | oxidoreductase activity, acting on CH or CH2 groups | single-organism process | small molecule metabolic process | exogenous drug catabolic process | epidermis development | response to xenobiotic stimulus | molting cycle process | oxidative demethylation | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | anatomical structure maturation | drug metabolic process | caffeine oxidase activity | hair cycle | anatomical structure development | metabolic process | developmental maturation | oxidation-reduction process | hair cycle process | cellular response to stimulus | organ development | organic acid metabolic process | developmental process | single-multicellular organism process | demethylation | cellular metabolic process | oxidoreductase activity | aromatase activity | hair follicle development | multicellular organismal process

GO Cellular Component

endoplasmic reticulum part | intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | organelle part | intracellular organelle part | membrane part | cell part | membrane-bounded organelle | organelle | cytoplasmic part | intracellular part | intracellular | membrane