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QuickView for CHRNA4 (gene)


Gene Symbol:
CHRNA4 Homo sapiens Homo sapiens
Full name:
cholinergic receptor, nicotinic, alpha 4 (neuronal)
Synonyms:
FLJ95812, NACHR, NACHRA4, NACRA4, neuronal acetylcholine receptor subunit alpha-4, neuronal nicotinic acetylcholine receptor alpha-4 subunit, cholinergic receptor, nicotinic, alpha 4 (neuronal), cholinergic receptor, nicotinic, alpha 4 subunit, cholinergic receptor, nicotinic, alpha polypeptide 4, BFNC, EBN, EBN1
Genomic Location:
Chr 20: 61445109-61463192
Description:
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membr...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 20
20q13.2-q13.3





GO Molecular Function

neurotransmitter receptor activity | ligand-gated channel activity | passive transmembrane transporter activity | neurotransmitter binding | transmembrane signaling receptor activity | transmembrane transporter activity | ligand-gated ion channel activity | binding | acetylcholine-activated cation-selective channel activity | cation transmembrane transporter activity | acetylcholine receptor activity | signaling receptor activity | transporter activity | ion transmembrane transporter activity | gated channel activity | extracellular ligand-gated ion channel activity | substrate-specific transmembrane transporter activity | acetylcholine binding | receptor activity | molecular transducer activity | signal transducer activity | excitatory extracellular ligand-gated ion channel activity | cation channel activity | substrate-specific transporter activity | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

regulation of biological process | regulation of cellular localization | regulation of localization | neurotransmitter receptor activity | establishment of localization | nucleic acid metabolic process | regulation of biological quality | ligand-gated channel activity | cellular macromolecule metabolic process | cellular chemical homeostasis | multicellular organismal signaling | cellular process | regulation of catecholamine secretion | localization | cellular homeostasis | passive transmembrane transporter activity | metal ion transport | synaptic transmission | response to hypoxia | transmembrane signaling receptor activity | regulation of cellular process | leukocyte activation | transmembrane transporter activity | organic cyclic compound metabolic process | ligand-gated ion channel activity | cellular aromatic compound metabolic process | behavioral response to nicotine | response to stimulus | response to chemical stimulus | transport | response to stress | divalent metal ion transport | cellular nitrogen compound metabolic process | response to decreased oxygen levels | cell-cell signaling | DNA repair | regulation of membrane potential | response to nicotine | response to oxygen levels | nitrogen compound metabolic process | acetylcholine-activated cation-selective channel activity | membrane hyperpolarization | response to DNA damage stimulus | ion transmembrane transport | response to abiotic stimulus | regulation of postsynaptic membrane potential | cellular response to stress | neurological system process | cation transmembrane transporter activity | cellular ion homeostasis | acetylcholine receptor activity | signaling receptor activity | single-organism process | transporter activity | response to oxidative stress | ion transmembrane transporter activity | gated channel activity | cognition | B cell activation | biological regulation | locomotory behavior | sensory perception of pain | extracellular ligand-gated ion channel activity | regulation of amine transport | substrate-specific transmembrane transporter activity | cell communication | system process | homeostatic process | regulation of dopamine secretion | lymphocyte activation | regulation of inhibitory postsynaptic membrane potential | response to organic substance | DNA metabolic process | signal transducer activity | metabolic process | primary metabolic process | chemical homeostasis | calcium ion transport | regulation of secretion | behavior | membrane depolarization | cellular response to stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | excitatory extracellular ligand-gated ion channel activity | ion homeostasis | response to alkaloid | cell activation | cation channel activity | adult behavior | substrate-specific transporter activity | sensory perception | regulation of cell communication | transmembrane transport | regulation of action potential | signaling | response to organic cyclic compound | single-organism behavior | cation transport | channel activity | regulation of transport | synaptic transmission, cholinergic | single-multicellular organism process | single organism signaling | divalent inorganic cation transport | heterocycle metabolic process | transmission of nerve impulse | ion channel activity | ion transport | immune system process | cellular metabolic process | substrate-specific channel activity | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

integral to membrane | dendrite | synapse | plasma membrane part | neuron projection | cell body | cell | neuronal cell body | intrinsic to membrane | synaptic membrane | external side of plasma membrane | receptor complex | synapse part | macromolecular complex | cell projection | postsynaptic membrane | plasma membrane | membrane part | integral to plasma membrane | cell part | cell periphery | ion channel complex | cell surface | cell junction | acetylcholine-gated channel complex | membrane | protein complex | intrinsic to plasma membrane