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QuickView for CHF1 (gene)


Gene Symbol:
HEY2 Homo sapiens Homo sapiens
Full name:
hairy/enhancer-of-split related with YRPW motif 2
Synonyms:
protein gridlock homolog, RP1-293L8.3, CHF1, class B basic helix-loop-helix protein 32, cardiovascular basic helix-loop-helix factor 1, cardiovascular helix-loop-helix factor 1, bHLHb32, GRL, hairy and enhancer of split-related protein 2, hairy-related transcription factor 2, hairy/enhancer-of-split related with YRPW motif 2, hairy/enhancer-of-split related with YRPW motif protein 2, GRIDLOCK, HERP1, HES-related repressor protein 1, HESR-2, HESR2, hHRT2, hCHF1, HRT-2, HRT2, OTTHUMP00000017138, MGC10720
Genomic Location:
Chr 6: 126112425-126124108
Description:
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signa...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 6
6q21


Transcripts Names
NM_012259
Protein Names
Q9UBP5



GO Molecular Function

sequence-specific DNA binding | satellite DNA binding | sequence-specific DNA binding RNA polymerase II transcription factor activity | enzyme binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | nucleic acid binding transcription factor activity | binding | DNA binding | organic cyclic compound binding | microsatellite binding | protein binding | sequence-specific DNA binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | protein dimerization activity | protein binding transcription factor activity | histone deacetylase binding | RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription from RNA polymerase II promoter | positive regulation of heart contraction | Notch signaling pathway | cell morphogenesis | ventricular cardiac muscle tissue morphogenesis | regulation of biological process | positive regulation of macromolecule biosynthetic process | ascending aorta development | regulation of neurogenesis | muscle tissue development | regulation of inner ear receptor cell differentiation | regulation of cell development | heart trabecula morphogenesis | regulation of biosynthetic process | regulation of programmed cell death | smooth muscle cell differentiation | nucleic acid metabolic process | dorsal aorta development | regulation of biological quality | negative regulation of cellular process | sequence-specific DNA binding RNA polymerase II transcription factor activity | positive regulation of developmental process | regulation of heart growth | regulation of cardiac muscle cell apoptotic process | cell differentiation | endothelial cell differentiation | cellular macromolecule metabolic process | nervous system development | epithelial to mesenchymal transition | neurogenesis | pulmonary valve development | generation of neurons | cardiac cell development | mesenchyme development | cardiac atrium morphogenesis | blood vessel morphogenesis | regulation of cardiac muscle cell proliferation | pattern specification process | regulation of response to stimulus | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | muscular septum morphogenesis | cardiac chamber morphogenesis | ascending aorta morphogenesis | localization | negative regulation of cardiac vascular smooth muscle cell differentiation | negative regulation of cellular component organization | heart morphogenesis | negative regulation of signaling | regulation of mechanoreceptor differentiation | regulation of striated muscle tissue development | macromolecule localization | negative regulation of apoptotic process | macromolecular complex subunit organization | positive regulation of nitrogen compound metabolic process | regulation of nucleobase-containing compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | regulation of system process | muscle structure development | muscle cell differentiation | ventricular septum morphogenesis | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | striated muscle adaptation | ventricular cardiac muscle cell development | organic cyclic compound metabolic process | trabecula morphogenesis | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | coronary vasculature morphogenesis | cellular component organization | ventricular trabecula myocardium morphogenesis | cardiac vascular smooth muscle cell development | blood vessel endothelial cell differentiation | muscle organ morphogenesis | cellular macromolecular complex subunit organization | regulation of vasculature development | response to stimulus | cardiac right ventricle morphogenesis | negative regulation of cell communication | vasculature development | muscle cell development | nucleic acid binding transcription factor activity | mesenchymal cell development | muscle adaptation | response to stress | regulation of macromolecule biosynthetic process | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | vascular smooth muscle cell differentiation | regulation of cardiac vascular smooth muscle cell differentiation | endocardial cushion to mesenchymal transition involved in heart valve formation | cardiac muscle tissue development | muscle tissue morphogenesis | regulation of anatomical structure morphogenesis | macromolecule biosynthetic process | protein-DNA complex assembly | regulation of transcription regulatory region DNA binding | regulation of heart rate | cellular localization | cardiovascular system development | cardiac ventricle morphogenesis | negative regulation of DNA-dependent transcription, initiation | cellular nitrogen compound metabolic process | regulation of DNA binding | negative regulation of metabolic process | regulation of cardiac muscle tissue growth | cellular component assembly | cellular biosynthetic process | embryo development | embryonic placenta development | blood vessel development | anterior/posterior pattern specification | pulmonary valve morphogenesis | system development | nitrogen compound metabolic process | regulation of signal transduction | endothelium development | heart valve formation | multicellular organismal development | positive regulation of RNA metabolic process | negative regulation of RNA metabolic process | negative regulation of striated muscle cell apoptotic process | positive regulation of multicellular organismal process | umbilical cord morphogenesis | cardiac muscle adaptation | cardiac epithelial to mesenchymal transition | artery development | regulation of neuron differentiation | regulation of gene expression | cellular component biogenesis | outflow tract morphogenesis | coronary vasculature development | positive regulation of cellular metabolic process | regulation of multicellular organismal development | regulation of smooth muscle cell differentiation | organ morphogenesis | regulation of macromolecule metabolic process | regulation of nitrogen compound metabolic process | single-organism process | placenta blood vessel development | regulation of Notch signaling pathway | cardiac atrium development | negative regulation of nitrogen compound metabolic process | negative regulation of DNA binding | cardiac cell differentiation | regulation of transcription from RNA polymerase II promoter | umbilical cord development | negative regulation of binding | negative regulation of smooth muscle cell differentiation | negative regulation of cardiac muscle cell apoptotic process | biological regulation | cardiac muscle hypertrophy | biosynthetic process | positive regulation of cardiac muscle cell proliferation | labyrinthine layer development | regulation of primary metabolic process | negative regulation of transcription regulatory region DNA binding | cardiac muscle cell development | cardiac septum morphogenesis | cellular macromolecular complex assembly | positive regulation of macromolecule metabolic process | labyrinthine layer blood vessel development | regulation of heart contraction | cell morphogenesis involved in differentiation | positive regulation of biological process | sensory organ development | regulation of cellular macromolecule biosynthetic process | negative regulation of response to stimulus | negative regulation of developmental process | negative regulation of nucleobase-containing compound metabolic process | regulation of muscle cell apoptotic process | chordate embryonic development | striated muscle tissue development | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | anterior/posterior axis specification | system process | positive regulation of biosynthetic process | vasculogenesis | inner ear development | heart development | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | striated muscle cell differentiation | positive regulation of heart rate | cellular component organization at cellular level | macromolecular complex assembly | tricuspid valve development | regulation of auditory receptor cell differentiation | heart valve development | ventricular septum development | sequence-specific DNA binding transcription factor activity | regionalization | cardiac ventricle development | axis specification | regulation of growth | regulation of cardiac muscle tissue development | tissue morphogenesis | artery morphogenesis | striated muscle hypertrophy | cellular developmental process | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | ventricular cardiac muscle tissue development | anatomical structure development | regulation of multicellular organismal process | cell surface receptor signaling pathway | aorta development | metabolic process | cell fate commitment | mesenchymal cell differentiation | primary metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-dependent | negative regulation of programmed cell death | embryonic organ development | cellular protein localization | ear development | cell surface receptor signaling pathway involved in heart development | negative regulation of muscle cell apoptotic process | cellular response to stimulus | nucleobase-containing compound metabolic process | negative regulation of protein complex assembly | heart valve morphogenesis | organic substance metabolic process | cellular component morphogenesis | negative regulation of biosynthetic process | negative regulation of gene expression | organ development | gene expression | dorsal aorta morphogenesis | regulation of vasculogenesis | negative regulation of biological process | atrioventricular valve development | transcription, DNA-dependent | aorta morphogenesis | atrial septum development | negative regulation of transcription initiation from RNA polymerase II promoter | pulmonary artery morphogenesis | anatomical structure formation involved in morphogenesis | cardiac muscle cell differentiation | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-dependent | negative regulation of macromolecule metabolic process | cell development | regulation of developmental growth | regulation of molecular function | protein localization | cellular component organization or biogenesis at cellular level | protein binding transcription factor activity | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | regulation of DNA-dependent transcription, initiation | regulation of organ growth | regulation of nervous system development | regulation of developmental process | developmental process | arterial endothelial cell differentiation | regulation of muscle cell differentiation | vascular smooth muscle cell development | cardiac septum development | negative regulation of cellular biosynthetic process | protein-DNA complex subunit organization | positive regulation of cellular process | negative regulation of transcription from RNA polymerase II promoter | positive regulation of transcription, DNA-dependent | regulation of cellular component biogenesis | atrial septum morphogenesis | cochlea development | ventricular cardiac muscle cell differentiation | epithelial cell differentiation | tricuspid valve formation | single-multicellular organism process | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | cardiac chamber development | heterocycle metabolic process | negative regulation of cellular macromolecule biosynthetic process | negative regulation of muscle cell differentiation | RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity | cardiac vascular smooth muscle cell differentiation | in utero embryonic development | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation | positive regulation of metabolic process | cellular component assembly at cellular level | tricuspid valve morphogenesis | negative regulation of Notch signaling pathway | cellular metabolic process | placenta development | regulation of cell death | negative regulation of cell death | circulatory system development | regulation of striated muscle cell apoptotic process | muscle hypertrophy | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | muscle system process | cardiac muscle hypertrophy in response to stress | cardiac left ventricle morphogenesis | signal transduction | muscle hypertrophy in response to stress | regulation of signaling | Notch signaling involved in heart development | negative regulation of transcription by transcription factor localization | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular non-membrane-bounded organelle | cytoplasm | intracellular organelle | nuclear chromosome part | macromolecular complex | nuclear part | histone deacetylase complex | nucleoplasm | chromatin | organelle part | intracellular organelle part | organelle lumen | nuclear chromosome | nucleoplasm part | Sin3 complex | chromosomal part | cell part | membrane-bounded organelle | transcriptional repressor complex | nucleus | Sin3-type complex | organelle | membrane-enclosed lumen | intracellular organelle lumen | nuclear chromatin | chromatin remodeling complex | non-membrane-bounded organelle | intracellular part | intracellular | protein complex