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QuickView for CACNA1C (gene)


Gene Symbol:
CACNA1C Homo sapiens Homo sapiens
Full name:
calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms:
CaV1.2, CCHL1A1, CACH2, CACN2, CACNL1A1, calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit, calcium channel, L type, alpha 1 polypeptide, isoform 1, cardic muscle, calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, calcium channel, voltage-dependent, L type, alpha 1C subunit, DHPR, alpha-1 subunit, voltage-dependent L-type calcium channel subunit alpha-1C, voltage-gated calcium channel alpha subunit Cav1.2, voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*, TS, LQT8, MGC120730, OTTHUMP00000196730, OTTHUMP00000196731, OTTHUMP00000196732, OTTHUMP00000196733, OTTHUMP00000196734, OTTHUMP00000196735, OTTHUMP00000196736, OTTHUMP00000196737, OTTHUMP00000196739, OTTHUMP00000196744, OTTHUMP00000196746, OTTHUMP00000196747, OTTHUMP00000196748, OTTHUMP00000196749, OTTHUMP00000196751
Genomic Location:
Chr 12: 2032725-2677376
Description:
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/d...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
EVI1 binding site geneset 5 Unknown transcription factor binding site geneset 16 PAX6 binding site geneset 1 GATA1 binding site geneset 2 FOXD3 binding site geneset 1 POU2F1 binding site geneset 1 POU2F1 binding site geneset 2 POU2F1 binding site geneset 4 POU3F2 binding site geneset 1 NF1 binding site geneset 2
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 12
12p13.3





GO Molecular Function

protein phosphatase 2A binding | voltage-gated ion channel activity | passive transmembrane transporter activity | enzyme binding | transmembrane transporter activity | alpha-actinin binding | binding | voltage-gated calcium channel activity | protein domain specific binding | cytoskeletal protein binding | cation transmembrane transporter activity | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | gated channel activity | divalent inorganic cation transmembrane transporter activity | substrate-specific transmembrane transporter activity | protein binding | protein phosphatase binding | metal ion transmembrane transporter activity | voltage-gated cation channel activity | cation channel activity | substrate-specific transporter activity | inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | calcium channel activity | calmodulin binding | phosphatase binding | actinin binding | ion channel activity | substrate-specific channel activity

GO Biological Process

cell morphogenesis | regulation of biological process | neuron projection morphogenesis | regulation of cellular localization | cytosolic calcium ion transport | regulation of localization | establishment of localization | regulation of biological quality | cell differentiation | nervous system development | generation of precursor metabolites and energy | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | voltage-gated ion channel activity | regulation of peptide hormone secretion | generation of neurons | cellular process | localization | cellular homeostasis | cell projection morphogenesis | passive transmembrane transporter activity | metal ion transport | neuron development | axon guidance | regulation of cellular process | cellular component organization or biogenesis | cytosolic calcium ion homeostasis | transmembrane transporter activity | cellular component organization | calcium ion homeostasis | calcium ion transport into cytosol | regulation of peptide secretion | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of transmembrane transport | response to chemical stimulus | transport | regulation of insulin secretion | divalent metal ion transport | regulation of peptide transport | metal ion homeostasis | voltage-gated calcium channel activity | locomotion | system development | multicellular organismal development | calcium ion transmembrane transport | taxis | ion transmembrane transport | regulation of hormone secretion | cation transmembrane transporter activity | cellular ion homeostasis | elevation of cytosolic calcium ion concentration | single-organism process | small molecule metabolic process | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | axonogenesis | gated channel activity | divalent inorganic cation transmembrane transporter activity | biological regulation | substrate-specific transmembrane transporter activity | cell morphogenesis involved in differentiation | cation homeostasis | cellular cation homeostasis | cellular calcium ion homeostasis | homeostatic process | neuron differentiation | cellular component organization at cellular level | cellular developmental process | metal ion transmembrane transporter activity | anatomical structure development | voltage-gated cation channel activity | cell projection organization | metabolic process | oxidation-reduction process | chemical homeostasis | calcium ion transport | regulation of secretion | neuron projection development | cellular component morphogenesis | ion homeostasis | regulation of ion transmembrane transport | cation channel activity | anatomical structure formation involved in morphogenesis | substrate-specific transporter activity | regulation of cell communication | transmembrane transport | inorganic cation transmembrane transporter activity | cell development | energy reserve metabolic process | cellular component organization or biogenesis at cellular level | voltage-gated channel activity | anatomical structure morphogenesis | cation transport | channel activity | cellular divalent inorganic cation homeostasis | regulation of ion transport | energy derivation by oxidation of organic compounds | developmental process | response to external stimulus | calcium channel activity | regulation of transport | cellular metal ion homeostasis | single-multicellular organism process | divalent inorganic cation transport | ion channel activity | ion transport | cellular metabolic process | chemotaxis | divalent inorganic cation homeostasis | substrate-specific channel activity | regulation of signaling | multicellular organismal process

GO Cellular Component

dendritic spine | integral to membrane | dendrite | sarcolemma | synapse | plasma membrane part | neuron projection | sarcomere | voltage-gated calcium channel complex | cell body | cell | neuronal cell body | intrinsic to membrane | intracellular non-membrane-bounded organelle | myofibril | cell projection part | cytoplasm | intracellular organelle | contractile fiber part | contractile fiber | synapse part | macromolecular complex | cell projection | neuron spine | plasma membrane | organelle part | intracellular organelle part | dendritic spine head | postsynaptic density | membrane part | T-tubule | cell part | calcium channel complex | organelle | I band | cell periphery | cytoplasmic part | cation channel complex | ion channel complex | Z disc | non-membrane-bounded organelle | cytoskeleton | intracellular part | intracellular | membrane | cytoskeletal part | protein complex