Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for CACNA1A (gene)


Gene Symbol:
CACNA1A Homo sapiens Homo sapiens
Full name:
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms:
CAV2.1, CACNL1A4, calcium channel, alpha 1A subunit, calcium channel, L type, alpha-1 polypeptide, calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, brain calcium channel 1, brain calcium channel I, EA2, APCA, BI, voltage-dependent P/Q-type calcium channel subunit alpha-1A, voltage-gated calcium channel subunit alpha Cav2.1, SCA6, MHP, MHP1, HPCA, FHM
Genomic Location:
Chr 19: 13178256-13478274
Description:
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Canis lupus familiaris Bos taurus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19p13





GO Molecular Function

high voltage-gated calcium channel activity | voltage-gated ion channel activity | passive transmembrane transporter activity | syntaxin binding | transmembrane transporter activity | binding | voltage-gated calcium channel activity | cation transmembrane transporter activity | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | gated channel activity | divalent inorganic cation transmembrane transporter activity | substrate-specific transmembrane transporter activity | protein binding | metal ion transmembrane transporter activity | voltage-gated cation channel activity | cation channel activity | substrate-specific transporter activity | SNARE binding | inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | calcium channel activity | calmodulin binding | ion channel activity | substrate-specific channel activity

GO Biological Process

behavioral response to pain | brain development | multicellular organismal movement | cell morphogenesis | regulation of biological process | reflex | exocytosis | regulation of transmission of nerve impulse | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | neurotransmitter secretion | regulation of cellular localization | regulation of cell development | regulation of localization | sulfur compound metabolic process | regulation of biosynthetic process | high voltage-gated calcium channel activity | regulation of programmed cell death | establishment of localization | spinal cord motor neuron differentiation | negative regulation of neuron death | regulation of biological quality | negative regulation of cellular process | glucose metabolic process | cell growth | cell differentiation | nervous system development | generation of precursor metabolites and energy | cerebellum morphogenesis | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | voltage-gated ion channel activity | regulation of peptide hormone secretion | generation of neurons | membrane organization | multicellular organismal signaling | neuromuscular process controlling balance | regulation of neuron death | cellular process | gamma-aminobutyric acid signaling pathway | secretion | death | musculoskeletal movement | localization | cellular homeostasis | cell projection morphogenesis | passive transmembrane transporter activity | metal ion transport | synaptic transmission | neuron development | central nervous system neuron differentiation | synapse assembly | anion homeostasis | central nervous system maturation | macromolecule localization | negative regulation of apoptotic process | regulation of neuron projection development | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of neurological system process | regulation of cell differentiation | regulation of system process | cellular amino acid metabolic process | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | regulation of acetylcholine secretion | cytosolic calcium ion homeostasis | transmembrane transporter activity | pons development | cellular component organization | calcium ion homeostasis | regulation of peptide secretion | response to stimulus | oxoacid metabolic process | cell morphogenesis involved in neuron differentiation | regulation of transmembrane transport | response to pain | metencephalon development | transport | regulation of insulin secretion | response to stress | cellular anion homeostasis | regulation of anatomical structure morphogenesis | receptor clustering | monovalent inorganic anion homeostasis | cell differentiation in hindbrain | cellular localization | divalent metal ion transport | secretion by cell | cellular monovalent inorganic anion homeostasis | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | cellular component assembly | negative regulation of hormone metabolic process | regulation of peptide transport | regulation of synaptic transmission | cell-cell signaling | metal ion homeostasis | cerebellar Purkinje cell layer formation | regulation of membrane potential | voltage-gated calcium channel activity | regulation of neurotransmitter levels | negative regulation of neuron apoptotic process | sulfur amino acid metabolic process | system development | ventral spinal cord development | multicellular organismal development | calcium ion transmembrane transport | regulation of axonogenesis | cerebellum development | gamma-aminobutyric acid secretion | regulation of hormone levels | ion transmembrane transport | regulation of hormone secretion | cellular membrane organization | regulation of neuron differentiation | rhythmic synaptic transmission | protein localization to membrane | cellular component biogenesis | organic substance transport | neurological system process | adult walking behavior | cation transmembrane transporter activity | regulation of multicellular organismal development | cellular ion homeostasis | adult locomotory behavior | elevation of cytosolic calcium ion concentration | single-organism process | monosaccharide metabolic process | small molecule metabolic process | vesicle-mediated transport | transporter activity | calcium ion transmembrane transporter activity | organic acid transport | synapse organization | ion transmembrane transporter activity | gated channel activity | cerebellar Purkinje cell differentiation | synaptic transmission, glutamatergic | divalent inorganic cation transmembrane transporter activity | neurotransmitter metabolic process | biological regulation | cellular ketone metabolic process | locomotory behavior | regulation of hormone metabolic process | hindbrain maturation | hindbrain development | cerebellum maturation | regulation of amine transport | carbohydrate metabolic process | substrate-specific transmembrane transporter activity | cell morphogenesis involved in differentiation | cation homeostasis | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | cerebellar cortex morphogenesis | system process | cellular calcium ion homeostasis | neuromuscular synaptic transmission | homeostatic process | anatomical structure maturation | amino acid transport | carboxylic acid metabolic process | gamma-aminobutyric acid transport | neuron differentiation | cellular chloride ion homeostasis | cellular component organization at cellular level | multicellular organismal response to stress | regulation of cell morphogenesis involved in differentiation | cellular developmental process | musculoskeletal movement, spinal reflex action | regulation of cellular biosynthetic process | metal ion transmembrane transporter activity | regulation of exocytosis | anatomical structure development | chloride ion homeostasis | regulation of multicellular organismal process | cell surface receptor signaling pathway | voltage-gated cation channel activity | cell projection organization | metabolic process | primary metabolic process | hexose metabolic process | developmental maturation | oxidation-reduction process | negative regulation of programmed cell death | cellular protein localization | cerebellar cortex development | regulation of vesicle-mediated transport | hindbrain morphogenesis | calcium ion-dependent exocytosis | chemical homeostasis | calcium ion transport | regulation of secretion | behavior | membrane depolarization | cellular response to stimulus | neuron projection development | cellular component morphogenesis | neuron-neuron synaptic transmission | cell death | cerebellar Purkinje cell layer development | negative regulation of biosynthetic process | organ development | ion homeostasis | regulation of ion transmembrane transport | negative regulation of biological process | growth | cation channel activity | dendrite morphogenesis | anatomical structure formation involved in morphogenesis | adult behavior | substrate-specific transporter activity | cell differentiation in spinal cord | calcium ion-dependent exocytosis of neurotransmitter | medulla oblongata development | negative regulation of hormone biosynthetic process | cerebellar cortex formation | regulation of cell communication | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | neuromuscular process | cell development | energy reserve metabolic process | single-organism behavior | protein localization | organic acid metabolic process | cellular component organization or biogenesis at cellular level | voltage-gated channel activity | carboxylic acid transport | hormone metabolic process | anatomical structure morphogenesis | cation transport | cellular macromolecule localization | channel activity | cellular divalent inorganic cation homeostasis | dendrite development | regulation of nervous system development | regulation of developmental process | regulation of ion transport | energy derivation by oxidation of organic compounds | cerebellar molecular layer development | developmental process | response to external stimulus | calcium channel activity | negative regulation of cellular biosynthetic process | regulation of transport | neurotransmitter transport | signal release | cellular metal ion homeostasis | single-multicellular organism process | single organism signaling | divalent inorganic cation transport | transmission of nerve impulse | vestibular nucleus development | regulation of calcium ion-dependent exocytosis | central nervous system development | ion channel activity | spinal cord development | regulation of neurotransmitter transport | cellular component assembly at cellular level | ion transport | cerebellar Purkinje cell layer morphogenesis | regulation of cell projection organization | cellular metabolic process | regulation of cell death | generation of a signal involved in cell-cell signaling | negative regulation of cell death | divalent inorganic cation homeostasis | substrate-specific channel activity | regulation of cellular component organization | neural nucleus development | signal transduction | regulation of signaling | regulation of hormone biosynthetic process | regulation of neurotransmitter secretion | multicellular organismal process

GO Cellular Component

integral to membrane | dendrite | intracellular membrane-bounded organelle | plasma membrane part | neuron projection | voltage-gated calcium channel complex | cell body | cell | neuronal cell body | intrinsic to membrane | cytoplasm | intracellular organelle | macromolecular complex | cell projection | plasma membrane | perikaryon | membrane part | cell part | calcium channel complex | membrane-bounded organelle | nucleus | organelle | cell periphery | cation channel complex | ion channel complex | intracellular part | intracellular | membrane | protein complex