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QuickView for Butethal (compound)


PubChem Substance
Name: butobarbital
PubChem Substance ID: 10413788
Synonyms:
Butabarbitol; Butobarbitalum; Butobarbitural; Budorm; 5-Ethyl-5-N-butylbarbituric acid; Monodorm; Butobarbital; Butyl,5-ethylbarbituric acid; 5-Ethyl-5-butylbarbituric acid; Meonal.
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DrugBank
Identification
Name: butobarbital
Name (isomeric): DB01353
Drug Type: small molecule
Synonyms:
Butabarbitol; Butobarbitural; Butobarbitalum; 5-Ethyl-5-N-butylbarbituric acid; Butobarbital; Butyl,5-ethylbarbituric acid; 5-Ethyl-5-butylbarbituric acid; 5-Butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Butyl-5-ethylbarbituric acid; Butobarbitone
Brand: Monodorm, Soneryl, Neonal, Hyperbutal, Meonal, Longanoct, Budorm, Sonerile, Etoval
Category: Anti-anxiety Agents, Hypnotics and Sedatives, Barbiturates
CAS number: 77-28-1
Pharmacology
Indication: For the treatment of insomnia.
Pharmacology: Butethal (also known as butobarbitone and butobarbital) belongs to a group of medicines called the barbiturates. It is thought to act on receptors in the brain (GABA receptors) causing the release of the chemical GABA. This chemical inhibits certain areas of the brain resulting in sleepiness.
Mechanism of Action:
Butethal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-s...
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Absorption: Rapidly absorbed following oral administration.
Biotransformation: Hepatic.
Half Life: 37 hours
Toxicity: Signs of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
PrednisoloneThe barbiturate, butethal, may decrease the effect of the corticosteroid, prednisolone.
DexamethasoneThe barbiturate, butethal, may decrease the effect of the corticosteroid, dexamethasone.
AminophyllineThe barbiturate, butethal, decreases the effect of aminophylline.
Ethinyl EstradiolThis product may cause a slight decrease of contraceptive effect
BetamethasoneThe barbiturate, butethal, may decrease the effect of the corticosteroid, betamethasone.
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Targets