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QuickView for BRCA1 (gene)


Gene Symbol:
BRCA1 Homo sapiens Homo sapiens
Full name:
breast cancer 1, early onset
Synonyms:
BRCA1/BRCA2-containing complex, subunit 1, BRCAI, BRCC1, breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein, breast and ovarian cancer sususceptibility protein 1, breast cancer 1, early onset, breast cancer type 1 susceptibility protein, BROVCA1, PNCA4, PPP1R53, IRIS, RING finger protein 53, RNF53, PSCP, protein phosphatase 1, regulatory subunit 53
Genomic Location:
Chr 17: 38449840-38530994
Description:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). T...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Unknown transcription factor binding site geneset 15 Unknown transcription factor binding site geneset 24 Unknown transcription factor binding site geneset 32 FALZ binding site geneset 1 STAT1 binding site geneset 4 NR1H4 binding site geneset 1 RXRA binding site geneset 1 Targets of MicroRNA ACTGAAA,MIR-30A-3P,MIR-30E-3P Targets of MicroRNA GACTGTT,MIR-212,MIR-132 Targets of MicroRNA GTGGTGA,MIR-197
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q21





GO Molecular Function

transcription factor binding transcription factor activity | regulatory region DNA binding | transcription regulatory region DNA binding | cation binding | hormone receptor binding | enzyme binding | nucleic acid binding | receptor binding | acid-amino acid ligase activity | binding | catalytic activity | ligase activity, forming carbon-nitrogen bonds | small conjugating protein ligase binding | small conjugating protein ligase activity | cytoskeletal protein binding | androgen receptor binding | DNA binding | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | transcription coactivator activity | protein binding | zinc ion binding | ubiquitin protein ligase binding | regulatory region nucleic acid binding | ligase activity | ubiquitin-protein ligase activity | transition metal ion binding | tubulin binding | protein binding transcription factor activity | steroid hormone receptor binding | transcription cofactor activity | metal ion binding | heterocyclic compound binding | RNA binding

GO Biological Process

small molecule biosynthetic process | double-strand break repair | response to radiation | cell morphogenesis | regulation of biological process | regulation of cell cycle process | transcription factor binding transcription factor activity | positive regulation of macromolecule biosynthetic process | carboxylic acid biosynthetic process | positive regulation of cellular component organization | G2/M transition checkpoint | intracellular signal transduction | regulation of localization | cell-substrate adhesion | regulation of biosynthetic process | regulation of programmed cell death | cellular response to indole-3-methanol | nucleic acid metabolic process | response to hormone stimulus | negative regulation of cellular process | substrate adhesion-dependent cell spreading | regulation of DNA metabolic process | cell differentiation | cellular macromolecule metabolic process | intrinsic apoptotic signaling pathway in response to DNA damage response | androgen receptor signaling pathway | DNA integrity checkpoint | regulation of protein modification process | regulation of organelle organization | regulation of DNA repair | regulation of response to stimulus | positive regulation of cellular biosynthetic process | cellular process | regulation of centriole replication | death | regulation of cell motility | negative regulation of cellular component organization | positive regulation of histone H4-K16 acetylation | regulation of histone H3-K9 methylation | regulation of histone modification | negative regulation of lipid biosynthetic process | postreplication repair | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | negative regulation of cellular metabolic process | regulation of transcription from RNA polymerase III promoter | regulation of histone H3-K9 acetylation | intrinsic apoptotic signaling pathway | negative regulation of histone methylation | regulation of cellular process | cellular component organization or biogenesis | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | regulation of response to stress | cellular aromatic compound metabolic process | cellular component organization | positive regulation of response to DNA damage stimulus | cellular lipid metabolic process | regulation of histone H4-K16 acetylation | positive regulation of histone H4 acetylation | negative regulation of protein modification process | regulation of histone methylation | response to stimulus | oxoacid metabolic process | monocarboxylic acid metabolic process | response to chemical stimulus | regulation of centrosome cycle | regulation of fatty acid biosynthetic process | chromosome segregation | positive regulation of protein metabolic process | negative regulation of centriole replication | response to stress | regulation of macromolecule biosynthetic process | regulation of cell proliferation | positive regulation of nucleobase-containing compound metabolic process | regulation of protein ubiquitination | G2/M transition DNA damage checkpoint | programmed cell death | acid-amino acid ligase activity | cellular nitrogen compound metabolic process | response to endogenous stimulus | negative regulation of metabolic process | protein modification process | cellular biosynthetic process | DNA recombination | macromolecule modification | protein K6-linked ubiquitination | catalytic activity | DNA repair | regulation of cellular response to stress | apoptotic process | ligase activity, forming carbon-nitrogen bonds | nitrogen compound metabolic process | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | double-strand break repair via homologous recombination | small conjugating protein ligase activity | positive regulation of RNA metabolic process | negative regulation of RNA metabolic process | response to DNA damage stimulus | lipid metabolic process | positive regulation of chromosome organization | response to abiotic stimulus | DNA damage response, signal transduction resulting in transcription | signal transduction in response to DNA damage | regulation of gene expression | positive regulation of histone H4-K20 methylation | negative regulation of histone H3-K9 methylation | negative regulation of centrosome cycle | cellular response to stress | cell cycle | regulation of histone H4 acetylation | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of macromolecule metabolic process | regulation of nitrogen compound metabolic process | single-organism process | protein modification by small protein conjugation | small molecule metabolic process | negative regulation of nitrogen compound metabolic process | regulation of cellular component movement | regulation of transcription from RNA polymerase II promoter | regulation of fatty acid metabolic process | fatty acid biosynthetic process | positive regulation of histone H3-K9 acetylation | biological regulation | cellular ketone metabolic process | biosynthetic process | regulation of primary metabolic process | regulation of cellular protein metabolic process | negative regulation of histone modification | lipid biosynthetic process | positive regulation of macromolecule metabolic process | cell morphogenesis involved in differentiation | positive regulation of biological process | regulation of cellular macromolecule biosynthetic process | response to estrogen stimulus | negative regulation of nucleobase-containing compound metabolic process | cell communication | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | regulation of protein metabolic process | positive regulation of biosynthetic process | regulation of histone H3-K4 methylation | regulation of locomotion | transcription coactivator activity | regulation of RNA metabolic process | regulation of lipid biosynthetic process | apoptotic signaling pathway | regulation of microtubule-based process | carboxylic acid metabolic process | protein polyubiquitination | positive regulation of cell cycle arrest | regulation of centrosome duplication | protein metabolic process | positive regulation of protein modification process | response to organic substance | protein ubiquitination | cellular developmental process | regulation of cellular biosynthetic process | negative regulation of macromolecule biosynthetic process | DNA metabolic process | positive regulation of peptidyl-lysine acetylation | protein autoubiquitination | anatomical structure development | ligase activity | negative regulation of lipid metabolic process | metabolic process | primary metabolic process | ubiquitin-protein ligase activity | regulation of peptidyl-lysine acetylation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-dependent | negative regulation of cytoskeleton organization | cell adhesion | regulation of response to DNA damage stimulus | cellular response to stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | cellular component morphogenesis | cell death | negative regulation of organelle organization | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of histone modification | negative regulation of cellular protein metabolic process | protein modification by small protein conjugation or removal | regulation of histone H4-K20 methylation | regulation of chromosome organization | negative regulation of biological process | fatty acid metabolic process | intracellular receptor mediated signaling pathway | negative regulation of protein metabolic process | negative regulation of chromosome organization | signaling | regulation of transcription, DNA-dependent | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | negative regulation of macromolecule metabolic process | response to indole-3-methanol | cell development | organic acid metabolic process | cellular protein metabolic process | protein binding transcription factor activity | anatomical structure morphogenesis | positive regulation of response to stimulus | regulation of cellular ketone metabolic process | positive regulation of DNA metabolic process | recombinational repair | developmental process | positive regulation of cell cycle process | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | negative regulation of cellular biosynthetic process | regulation of histone acetylation | positive regulation of cellular process | positive regulation of histone acetylation | positive regulation of transcription, DNA-dependent | organic acid biosynthetic process | transcription cofactor activity | single organism signaling | positive regulation of transcription from RNA polymerase II promoter | heterocycle metabolic process | negative regulation of cellular macromolecule biosynthetic process | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of execution phase of apoptosis | positive regulation of histone methylation | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of cell death | response to steroid hormone stimulus | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of fatty acid biosynthetic process | biological adhesion | positive regulation of protein ubiquitination | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | response to ionizing radiation | regulation of cytoskeleton organization | negative regulation of fatty acid metabolic process | signal transduction | positive regulation of gene expression | positive regulation of DNA repair | macromolecule metabolic process

GO Cellular Component

BRCA1-BARD1 complex | intracellular membrane-bounded organelle | plasma membrane part | ruffle | adherens junction | microtubule organizing center | nuclear ubiquitin ligase complex | focal adhesion | cell | gamma-tubulin large complex | nuclear lumen | intracellular non-membrane-bounded organelle | cytoplasm | microtubule organizing center part | cell-substrate junction | intracellular organelle | actin cytoskeleton | ubiquitin ligase complex | macromolecular complex | cell projection | nuclear part | BRCA1-A complex | nucleoplasm | plasma membrane | organelle part | cell leading edge | intracellular organelle part | organelle lumen | ribonucleoprotein complex | gamma-tubulin ring complex | microtubule cytoskeleton | filamentous actin | membrane part | cell part | gamma-tubulin complex | membrane-bounded organelle | nucleus | organelle | anchoring junction | cell periphery | cytoplasmic part | membrane-enclosed lumen | basolateral plasma membrane | cell-substrate adherens junction | intracellular organelle lumen | non-membrane-bounded organelle | actin filament | cytoskeleton | intracellular part | intracellular | cell junction | membrane | cytoskeletal part | protein complex