Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for BRAF (gene)


Gene Symbol:
BRAF Homo sapiens Homo sapiens
Full name:
v-raf murine sarcoma viral oncogene homolog B1
Synonyms:
proto-oncogene B-Raf, v-raf murine sarcoma viral oncogene homolog B1, serine/threonine-protein kinase B-raf, RAFB1, MGC126806, MGC138284, NS7, murine sarcoma viral (v-raf) oncogene homolog B1, BRAF1, B-Raf, B-raf 1, B-Raf proto-oncogene serine/threonine-protein kinase (p94), B-RAF1, 94 kDa B-raf protein, FLJ95109
Genomic Location:
Chr 7: 140080751-140271033
Description:
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defect...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CREB1 binding site geneset 1 JUN binding site geneset 1 CREB1 binding site geneset 2 Unknown transcription factor binding site geneset 20 JUN binding site geneset 2 CREB1 binding site geneset 3 CREB1 binding site geneset 4 ATF2 binding site geneset 2 ESR1 binding site geneset 1 TP53 binding site geneset 1
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 7
7q34





GO Molecular Function

kinase binding | cation binding | protein kinase binding | receptor signaling protein serine/threonine kinase activity | enzyme binding | ribonucleotide binding | nucleotide binding | protein serine/threonine kinase activity | binding | catalytic activity | receptor signaling protein activity | ATP binding | adenyl nucleotide binding | MAP kinase kinase kinase activity | purine nucleotide binding | mitogen-activated protein kinase kinase binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | nucleoside phosphate binding | molecular transducer activity | purine ribonucleoside triphosphate binding | protein binding | protein dimerization activity | signal transducer activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | calcium ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | regulation of biological process | intracellular signal transduction | positive regulation of cell communication | regulation of programmed cell death | response to hormone stimulus | negative regulation of neuron death | negative regulation of cellular process | response to metal ion | cellular macromolecule metabolic process | positive regulation of phosphate metabolic process | regulation of protein modification process | multicellular organismal signaling | regulation of response to stimulus | regulation of neuron death | cellular process | synaptic transmission | positive regulation of peptidyl-serine phosphorylation | anti-apoptosis | positive regulation of protein kinase activity | negative regulation of apoptotic process | receptor signaling protein serine/threonine kinase activity | response to growth factor stimulus | positive regulation of catalytic activity | cellular response to chemical stimulus | response to inorganic substance | response to peptide hormone stimulus | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | MAPK cascade | cellular response to metal ion | response to stimulus | response to chemical stimulus | cellular response to fibroblast growth factor stimulus | positive regulation of protein metabolic process | signal transduction by phosphorylation | protein serine/threonine kinase activity | cellular response to inorganic substance | response to endogenous stimulus | protein modification process | macromolecule modification | cell-cell signaling | activation of protein kinase activity | catalytic activity | negative regulation of neuron apoptotic process | receptor signaling protein activity | system development | regulation of signal transduction | multicellular organismal development | regulation of MAPK cascade | phosphorus metabolic process | intracellular protein kinase cascade | regulation of catalytic activity | regulation of phosphorylation | fibroblast growth factor receptor signaling pathway | regulation of gene expression | neurological system process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | organ morphogenesis | regulation of macromolecule metabolic process | MAP kinase kinase kinase activity | regulation of transferase activity | single-organism process | enzyme linked receptor protein signaling pathway | positive regulation of intracellular protein kinase cascade | biological regulation | regulation of primary metabolic process | regulation of cellular protein metabolic process | phosphorylation | positive regulation of macromolecule metabolic process | protein phosphorylation | positive regulation of biological process | phosphate-containing compound metabolic process | positive regulation of phosphorus metabolic process | cell communication | positive regulation of transferase activity | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | activation of MAPKK activity | regulation of protein metabolic process | system process | positive regulation of signal transduction | regulation of protein phosphorylation | positive regulation of molecular function | protein metabolic process | positive regulation of protein modification process | cellular response to calcium ion | response to organic substance | nerve growth factor receptor signaling pathway | regulation of kinase activity | regulation of intracellular protein kinase cascade | anatomical structure development | cell surface receptor signaling pathway | signal transducer activity | metabolic process | transferase activity, transferring phosphorus-containing groups | primary metabolic process | negative regulation of programmed cell death | phosphotransferase activity, alcohol group as acceptor | cellular response to stimulus | protein kinase activity | organ development | cellular response to endogenous stimulus | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | transferase activity | regulation of phosphate metabolic process | negative regulation of biological process | response to cAMP | positive regulation of MAPK cascade | response to epidermal growth factor stimulus | regulation of peptidyl-serine phosphorylation | regulation of cell communication | signaling | regulation of molecular function | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | positive regulation of response to stimulus | kinase activity | developmental process | cellular protein modification process | positive regulation of cellular process | response to fibroblast growth factor stimulus | single-multicellular organism process | single organism signaling | transmission of nerve impulse | response to calcium ion | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | plasma membrane | cell part | membrane-bounded organelle | nucleus | organelle | cell periphery | cytoplasmic part | cytosol | intracellular part | intracellular | membrane