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QuickView for Anion exchange protein 1 (gene)


Gene Symbol:
SLC4A1 Homo sapiens Homo sapiens
Full name:
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
Synonyms:
anion exchange protein 1, anion exchanger 1, anion exchanger-1, AE1, DI, CD233, BND3, band 3 anion transport protein, FR, Froese blood group, erythrocyte membrane protein band 3, erythroid anion exchange protein, EMPB3, EPB3, solute carrier family 4, anion exchanger, member 1, solute carrier family 4, anion exchanger, number 1, SW, Swann blood group, WD, WD1, WR, Wright blood group, Waldner blood group, RTA1A, MGC116750, MGC116753, MGC126619, MGC126623
Genomic Location:
Chr 17: 39682566-39700993
Description:
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa do...
Orthologs:
Mus musculus Rattus norvegicus Bos taurus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Unknown transcription factor binding site geneset 2 GATA3 binding site geneset 1 GATA1 binding site geneset 2 GATA1 binding site geneset 3 GATA1 binding site geneset 4 GATA1 binding site geneset 5 LMO2 binding site geneset 1 LMO2 binding site geneset 2 PAX4 binding site geneset 1 ZIC1 binding site geneset 1
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q21.31


Transcripts Names
NM_000342



GO Molecular Function

inorganic anion exchanger activity | actin binding | anion transmembrane transporter activity | transmembrane transporter activity | protein anchor | inorganic anion transmembrane transporter activity | binding | anion:anion antiporter activity | chloride transmembrane transporter activity | cytoskeletal protein binding | antiporter activity | active transmembrane transporter activity | transporter activity | identical protein binding | ion transmembrane transporter activity | substrate-specific transmembrane transporter activity | ankyrin binding | protein binding | protein homodimerization activity | protein dimerization activity | secondary active transmembrane transporter activity | substrate-specific transporter activity | protein C-terminus binding

GO Biological Process

inorganic anion exchanger activity | establishment of localization | anion transmembrane transporter activity | regulation of biological quality | cellular chemical homeostasis | cellular process | localization | cellular homeostasis | anion transport | transmembrane transporter activity | transport | chloride transport | inorganic anion transport | inorganic anion transmembrane transporter activity | anion:anion antiporter activity | chloride transmembrane transporter activity | ion transmembrane transport | cellular ion homeostasis | antiporter activity | active transmembrane transporter activity | small molecule metabolic process | transporter activity | ion transmembrane transporter activity | biological regulation | bicarbonate transport | organic anion transport | substrate-specific transmembrane transporter activity | homeostatic process | metabolic process | chemical homeostasis | ion homeostasis | secondary active transmembrane transporter activity | substrate-specific transporter activity | transmembrane transport | ion transport

GO Cellular Component

integral to membrane | plasma membrane part | sarcomere | cell | cell cortex part | intrinsic to membrane | intracellular non-membrane-bounded organelle | myofibril | cytoplasm | cortical cytoskeleton | intracellular organelle | contractile fiber part | contractile fiber | plasma membrane | organelle part | membrane part | integral to plasma membrane | cell part | cell cortex | organelle | I band | cell periphery | cytoplasmic part | basolateral plasma membrane | Z disc | non-membrane-bounded organelle | cytoskeleton | intracellular part | intracellular | membrane | intrinsic to plasma membrane