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QuickView for Ampicillin (compound)


PubChem
Name: Ampicillin
PubChem Compound ID: 11840918
Description: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Molecular formula: C16H21N3O4S
Molecular weight: 351.422 g/mol
Synonyms:
6-[D(-)-ALPHA-AMINOPHENYLLACETAMIDO]PENICILLANIC ACID; Ampicillin; D(-)-ALPHA-AMINOBENZYLPENICILLIN; (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID; AIC
DrugBank
Identification
Name: Ampicillin
Name (isomeric): DB00415
Drug Type: small molecule
Description: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Synonyms:
Ampicillin Acid; Ampicillin Base; Ampicilline; Ampicilina [INN-Spanish]; Ampicillin Trihydrate; Ampicillinum [INN-Latin]; Anhydrous Ampicillin; Aminobenzylpenicillin; D-Ampicillin; Ampicillin Sodium.
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Brand: Ampi-Co, Ampiscel, Penbrock, Ro-Ampen, Principen, Pen A, Deripen, Morepen, Amfipen V, Roscillin, Totacillin, Amcill, Ultrabron, Ampivax, Omnipen-N, Pfizerpen A, AB-PC, Omnipen, Servicillin, Principen '250', Texcillin, Viccillin, Pen a Oral, Ampisyn, Adobacillin, Viccillin S, Bonapicillin, Ampy-Penyl, Lifeampil, Ampimed, Amipenix S, Penbritin-S, Wypicil, Vampen, Guicitrine, Sk-Ampicillin, Amblosin, Cimex, Amplipenyl, Semicillin R, Grampenil, Totapen, Racenacillin, Copharcilin, Binotal, Duphacillin, Britacil, Amplisom, Divercillin, Ampikel, Pen Ampil, Penicline, Polycillin-N, Ampen, Ampicil, Ampifarm, Geocillin, Amfipen, Ampicin, Totacillin-N, Penbritin, Ultrabion, Trifacilina, Alpen, Norobrittin, Polycillin, Ampi-Tab, Austrapen, Ab-Pc Sol, Ampivet, Semicillin, Amplital, Ampi-Bol, Olin Kid, Delcillin, Principen '500', Qidamp, Tokiocillin, Ampipenin, Pensyn, D-Cillin, Pentrexyl, Pentrexl, Guicitrina, Penbritin Paediatric, Amplacilina, Supen, Ampichel, Totalciclina, Penbristol, Ampipenin, Nt3, Tolomol, Sumipanto, Principen '125', Spectrobid, Nuvapen, Pfizerpen-A, Ponecil, Doktacillin, Rosampline, Orbicilina, Campicillin, Synpenin, Acillin, Pentrex, Princillin, BRL, Ampicillin A, Penbritin Syrup, Amplin, Ampi, Novo-Ampicillin, Penimic
Brand name mixture: Pro Biosan Kit(Ampicillin + Probenecid), Synergistin Injectable Suspension(Ampicillin + Sulbactam (Sulbactam Benzathine))
Category: Anti-Bacterial Agents, Penicillins
CAS number: 69-53-4
Pharmacology
Indication: For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
Pharmacology:
Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has in vitro activity against gram...
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Mechanism of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin interferes with an autolysin inhibitor.
Route of elimination: Ampicillin is excreted largely unchanged in the urine.
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Food interaction:
Take on an empty stomach.
Drug interaction:
OxytetracyclinePossible antagonism of action
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
MethacyclinePossible antagonism of action
DoxycyclinePossible antagonism of action
DemeclocyclinePossible antagonism of action
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