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QuickView for Aminophylline (compound)


PubChem
Name: Aminophylline
PubChem Compound ID: 3048502
Description: A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.
Molecular formula: C21H28N8O5
Molecular weight: 472.498 g/mol
Synonyms:
63907-40-4; Novophyllin
DrugBank
Identification
Name: Aminophylline
Name (isomeric): DB01223
Drug Type: small molecule
Description: A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.
Synonyms:
Aminophylline Anhydrous; Aminophylline Dye Free; Aminophyllin; Aminophylline Dihydrate
Brand: Cardophylin, Metaphylline, Vasofilina, Etilen-Xantisan Tabl., Dura-Tab S.M. Aminophylline, Inophylline, Diophllin, Thephyldine, Lasodex, Carena, Rectalad-Aminophylline, Grifomin, Ethophylline, Diaphylline, Stenovasan, Syntophyllin, Variaphylline, Theophyllin Aethylendiamin, Theophyldine, Theolone, Norofilina, Miofilin, Eurphyllin, Rectalad Aminophylline, Cardiofilina, Theophylline Ethylenediamine, Genophyllin, Phyllindon, Phyllocontin-350, Cardophyllin, Metaphyllin, Theophyllaminum, Theodrox, Lixaminol, Ammophyllin, Phylcardin, Somophyllin-O, Euufillin, Theolamine, Diuxanthine, Minaphil, Dobo, Cardiomin, Theophyllamine, Linampheta, Aminodur, Methophylline, Neophyiline, Theophyllin Ethylenediamine, Somophyllin O, Truphylline, Theophyline Ethylenediamine, Phyllocontin, Somophyllin, Peterphyllin, Aminocardol, Cariomin
Brand name mixture: Quiex Liq(Aminophylline + Guaifenesin), Ami-Nesine Liq(Aminophylline + Guaifenesin), Quiex-Pred Sus(Aminophylline + Guaifenesin + Prednisolone), Quiex - Forte Syr(Aminophylline + Guaifenesin), Quiex-K1 Syr(Aminophylline + Guaifenesin + Potassium Iodide)
Category: Respiratory Smooth Muscle Relaxants, Phosphodiesterase Inhibitors, Cardiotonic Agents, Bronchodilator Agents
CAS number: 317-34-0
Pharmacology
Indication: For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
Pharmacology: Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi through PDE3 inhibition, produces diuresis, and causes an increase in gastric secretion.
Mechanism of Action: Theophylline is structurally related to theobromine and caffeine. The precise mechanism of action of theophylline is not known, however, it is thought to be a phosphodiesterase inhibitor which may give a bronchodilatory effect. It also binds adenosine receptors.
Protein binding: 60%
Half Life: 7-9 hours
Clearance: 0.29 mL/kg/min [postnatal age 3-15 days] 0.64 mL/kg/min [postnatal age 25-57 days] 1.7 mL/kg/min [ 1-4 years] 1.6 mL/kg/min [4-12 years] 0.9 mL/kg/min [13-15 years] 1.4 mL/kg/min [16-17 years] 0.65 mL/kg/min [Adults (16-60 years), non-smoking asthmatics] 0.41 mL/kg/min [Elderly (>60 years). liver, and renal function] 0.33 mL/kg/min [Acute pulmonary edema] 0.54 mL/kg/min [COPD->60 years, stable non-smoker >1 year] 0.48 mL/kg/min [COPD with cor pulmonale] 1.25 mL/kg/min [Cystic fibrosis (14-28 years)] 0.31 mL/kg/min [Liver disease -cholestasis] 0.35 mL/kg/min [cirrhosis] 0.65 mL/kg/min [acute hepatitis] 0.47 mL/kg/min [Sepsis with multi-organ failure] 0.38 mL/kg/min [hypothyroid] 0.8 mL/kg/min [hyperthyroid]
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Vitamin B6 needs increased, supplement recommended.
Limit caffeine intake.
Take with food.
Drug interaction:
MestranolThe contraceptive increases the effect and toxicity of theophylline
VecuroniumTheophylline decreases the effect of muscle relaxant
PhenobarbitalThe barbiturate, phenobarbital, decreases the effect of aminophylline.
AtracuriumTheophylline decreases the effect of muscle relaxant
ButabarbitalThe barbiturate, butabarbital, decreases the effect of aminophylline.
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