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QuickView for ADTB2 (gene)


Gene Symbol:
AP2B1 Homo sapiens Homo sapiens
Full name:
adaptor-related protein complex 2, beta 1 subunit
Synonyms:
CLAPB1, clathrin assembly protein complex 2 beta large chain, clathrin-associated/assembly/adaptor protein, large, beta 1, adapter-related protein complex 2 beta subunit, adaptin, beta 2 (beta), adaptor protein complex AP-2 subunit beta, adaptor-related protein complex 2, beta 1 subunit, ADTB2, AP-2 complex subunit beta, AP105B, AP2-BETA, DKFZp781K0743, beta-adaptin, beta-2-adaptin, plasma membrane adaptor HA2/AP2 adaptin beta subunit
Genomic Location:
Chr 17: 30938395-31077549
Description:
The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [pr...
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Schizosaccharomyces pombe Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q11.2-q12


Transcripts Names
NM_001030006
NM_001282
Protein Names
Q96J19
Q96EL6
P63010
A6NJP3
P21851



GO Molecular Function

clathrin binding | protein complex binding | protein transporter activity | binding | transporter activity | protein binding | substrate-specific transporter activity

GO Biological Process

molting cycle | cell morphogenesis | regulation of biological process | antigen processing and presentation | neuron projection morphogenesis | neurotransmitter secretion | regulation of multi-organism process | establishment of localization | regulation of immune system process | regulation of biological quality | negative regulation of cellular process | cell differentiation | nervous system development | cell part morphogenesis | neurogenesis | generation of neurons | membrane organization | intracellular transport | multicellular organismal signaling | regulation of response to stimulus | cellular process | secretion | localization | cell projection morphogenesis | regulation of defense response | exogen | protein transport | negative regulation of signaling | synaptic transmission | neuron development | macromolecule localization | axon guidance | regulation of defense response to virus | macromolecular complex subunit organization | establishment of localization in cell | tissue development | regulation of cellular process | cellular component organization or biogenesis | epidermal growth factor receptor signaling pathway | regulation of response to stress | negative regulation of epidermal growth factor receptor signaling pathway | cellular component organization | protein transporter activity | cellular macromolecular complex subunit organization | response to stimulus | negative regulation of cell communication | cell morphogenesis involved in neuron differentiation | response to chemical stimulus | transport | protein complex assembly | intracellular protein transport | hair follicle maturation | cellular localization | secretion by cell | antigen processing and presentation of exogenous peptide antigen via MHC class II | ERBB signaling pathway | cellular component assembly | protein complex subunit organization | cell-cell signaling | regulation of neurotransmitter levels | locomotion | system development | regulation of signal transduction | antigen processing and presentation of peptide antigen via MHC class II | multicellular organismal development | taxis | cellular membrane organization | vesicle coating | cellular component biogenesis | neurological system process | protein complex biogenesis | single-organism process | enzyme linked receptor protein signaling pathway | vesicle-mediated transport | transporter activity | multi-organism process | axonogenesis | biological regulation | cellular macromolecular complex assembly | epidermis development | molting cycle process | cell morphogenesis involved in differentiation | cellular protein complex assembly | negative regulation of response to stimulus | cell communication | synaptic vesicle endocytosis | antigen processing and presentation of exogenous peptide antigen | system process | anatomical structure maturation | viral reproduction | neuron differentiation | cellular component organization at cellular level | antigen processing and presentation of exogenous antigen | macromolecular complex assembly | hair cycle | nerve growth factor receptor signaling pathway | cellular developmental process | regulation of immune effector process | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | regulation of defense response to virus by virus | clathrin coat assembly | developmental maturation | cellular protein localization | hair cycle process | endocytosis | cellular response to stimulus | negative regulation of ERBB signaling pathway | neuron projection development | regulation of epidermal growth factor receptor signaling pathway | cellular component morphogenesis | organ development | negative regulation of biological process | establishment of protein localization | vesicle organization | membrane budding | anatomical structure formation involved in morphogenesis | substrate-specific transporter activity | regulation of cell communication | negative regulation of signal transduction | signaling | cell development | regulation of ERBB signaling pathway | protein localization | cellular component organization or biogenesis at cellular level | anatomical structure morphogenesis | cellular macromolecule localization | developmental process | response to external stimulus | organelle organization | regulation of response to biotic stimulus | neurotransmitter transport | signal release | antigen processing and presentation of peptide antigen | single-multicellular organism process | single organism signaling | transmission of nerve impulse | transmembrane receptor protein tyrosine kinase signaling pathway | cellular component assembly at cellular level | immune system process | synaptic vesicle transport | generation of a signal involved in cell-cell signaling | chemotaxis | hair follicle development | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | clathrin-coated endocytic vesicle membrane | coated membrane | endocytic vesicle membrane | clathrin-coated vesicle membrane | organelle membrane | clathrin-coated vesicle | cytoplasmic vesicle | cell | cytoplasm | clathrin-coated endocytic vesicle | intracellular organelle | AP-type membrane coat adaptor complex | macromolecular complex | clathrin adaptor complex | endomembrane system | plasma membrane | organelle part | intracellular organelle part | vesicle | coated pit | membrane part | cell part | coated vesicle membrane | membrane-bounded organelle | clathrin coat | organelle | vesicle membrane | cell periphery | cytoplasmic part | cytoplasmic membrane-bounded vesicle | trans-Golgi network | cytoplasmic vesicle part | membrane-bounded vesicle | cytosol | intracellular part | endocytic vesicle | intracellular | membrane | cytoplasmic vesicle membrane | protein complex | membrane coat | coated vesicle