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QuickView for ADRA2R (gene)


Gene Symbol:
ADRA2A Homo sapiens Homo sapiens
Full name:
adrenoceptor alpha 2A
Synonyms:
ADRA2, ADRA2R, ADRAR, adrenergic, alpha-2A-, receptor, adrenoceptor alpha 2A, ALPHA2AAR, alpha-2 adrenergic receptor subtype C10, alpha-2-adrenergic receptor, platelet type, alpha-2A adrenergic receptor, alpha-2A adrenoceptor, alpha-2A adrenoreceptor, alpha-2A-adrenergic receptor, alpha-2AAR subtype C10, ZNF32, OTTHUMP00000058849
Genomic Location:
Chr 10: 112826911-112830560
Description:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed tha...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Danio rerio Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Cytogenetic Map:
chr 10
10q25.2


Transcripts Names
NM_000681



GO Molecular Function

alpha-1B adrenergic receptor binding | kinase binding | catecholamine binding | epinephrine binding | heterotrimeric G-protein binding | protein kinase binding | alpha-adrenergic receptor activity | transmembrane signaling receptor activity | enzyme binding | protein complex binding | G-protein coupled receptor activity | receptor binding | G-protein coupled amine receptor activity | adrenergic receptor binding | binding | adrenergic receptor activity | signaling receptor activity | identical protein binding | protein heterodimerization activity | thioesterase binding | alpha2-adrenergic receptor activity | receptor activity | molecular transducer activity | alpha-2C adrenergic receptor binding | amine binding | protein binding | protein homodimerization activity | protein dimerization activity | signal transducer activity | G-protein coupled receptor binding | norepinephrine binding

GO Biological Process

negative regulation of G-protein coupled receptor protein signaling pathway | positive regulation of cellular catabolic process | regulation of biological process | positive regulation of locomotion | actin filament-based process | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | regulation of localization | regulation of biosynthetic process | positive regulation of cell communication | positive regulation of peptidyl-tyrosine phosphorylation | actin cytoskeleton organization | response to hormone stimulus | regulation of biological quality | negative regulation of cellular process | regulation of MAP kinase activity | activation of MAPK activity by adrenergic receptor signaling pathway | positive regulation of receptor activity | cellular macromolecule metabolic process | positive regulation of protein catabolic process | generation of precursor metabolites and energy | glucose homeostasis | positive regulation of phosphate metabolic process | regulation of protein modification process | positive regulation of cellular component movement | regulation of peptide hormone secretion | regulation of response to stimulus | cellular process | regulation of catecholamine secretion | positive regulation of epidermal growth factor-activated receptor activity | regulation of cell motility | negative regulation of signaling | positive regulation of protein kinase activity | hemostasis | negative regulation of secretion | regulation of proteolysis | alpha-adrenergic receptor activity | positive regulation of catalytic activity | transmembrane signaling receptor activity | regulation of nucleobase-containing compound metabolic process | cellular response to chemical stimulus | negative regulation of hormone secretion | negative regulation of cellular metabolic process | regulation of lyase activity | regulation of cellular process | cellular component organization or biogenesis | regulation of metabolic process | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | regulation of response to stress | positive regulation of catabolic process | cellular component organization | negative regulation of nucleotide metabolic process | positive regulation of potassium ion transport | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | G-protein coupled receptor activity | regulation of peptide secretion | negative regulation of purine nucleotide biosynthetic process | negative regulation of lyase activity | response to stimulus | negative regulation of cell communication | phospholipase C-activating adrenergic receptor signaling pathway | regulation of transmembrane transport | response to chemical stimulus | negative regulation of cAMP biosynthetic process | regulation of peptidyl-tyrosine phosphorylation | regulation of insulin secretion | positive regulation of protein metabolic process | regulation of norepinephrine secretion | response to stress | positive regulation of membrane protein ectodomain proteolysis | regulation of cell proliferation | regulation of nucleotide biosynthetic process | G-protein coupled amine receptor activity | negative regulation of transporter activity | regulation of metal ion transport | positive regulation of proteolysis | negative regulation of adrenergic receptor signaling pathway | negative regulation of transport | G-protein coupled receptor signaling pathway | response to endogenous stimulus | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | regulation of wound healing | protein modification process | regulation of cAMP metabolic process | regulation of peptide transport | regulation of epinephrine secretion | negative regulation of purine nucleotide metabolic process | macromolecule modification | activation of protein kinase activity | positive regulation of ERBB signaling pathway | blood coagulation | cellular response to hormone stimulus | regulation of protein tyrosine kinase activity | adrenergic receptor activity | negative regulation of epinephrine secretion | regulation of signal transduction | negative regulation of catalytic activity | regulation of MAPK cascade | phosphorus metabolic process | negative regulation of lipid catabolic process | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | positive regulation of multicellular organismal process | adenylate cyclase-inhibiting adrenergic receptor signaling pathway | regulation of catalytic activity | regulation of insulin secretion involved in cellular response to glucose stimulus | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of hormone secretion | wound healing | platelet activation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | digestive system process | regulation of macromolecule metabolic process | regulation of transferase activity | signaling receptor activity | regulation of nitrogen compound metabolic process | single-organism process | regulation of cyclic nucleotide biosynthetic process | regulation of cell migration | small molecule metabolic process | negative regulation of nitrogen compound metabolic process | receptor transactivation | regulation of cellular component movement | negative regulation of catabolic process | negative regulation of norepinephrine secretion | activation of protein kinase B activity | positive regulation of cell migration | intestinal absorption | negative regulation of nucleotide biosynthetic process | biological regulation | negative regulation of calcium ion transmembrane transporter activity | regulation of primary metabolic process | negative regulation of cyclic nucleotide biosynthetic process | cellular component movement | regulation of cellular protein metabolic process | negative regulation of peptide hormone secretion | regulation of amine transport | phosphorylation | negative regulation of ion transport | negative regulation of adenylate cyclase activity | regulation of membrane protein ectodomain proteolysis | positive regulation of macromolecule metabolic process | regulation of cyclase activity | negative regulation of cAMP metabolic process | protein phosphorylation | regulation of cellular catabolic process | positive regulation of biological process | phosphate-containing compound metabolic process | regulation of purine nucleotide metabolic process | negative regulation of response to stimulus | positive regulation of phosphorus metabolic process | negative regulation of nucleobase-containing compound metabolic process | regulation of nucleotide metabolic process | alpha2-adrenergic receptor activity | cell communication | positive regulation of transferase activity | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of lipid catabolic process | regulation of cAMP biosynthetic process | negative regulation of calcium ion transport | regulation of protein metabolic process | system process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | positive regulation of transport | regulation of purine nucleotide biosynthetic process | negative regulation of insulin secretion involved in cellular response to glucose stimulus | coagulation | negative regulation of catecholamine secretion | regulation of catabolic process | regulation of potassium ion transport | positive regulation of molecular function | negative regulation of exocytosis | epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | activation of MAPK activity | regulation of receptor activity | cellular component organization at cellular level | regulation of epidermal growth factor-activated receptor activity | multicellular organismal response to stress | fear response | protein metabolic process | positive regulation of protein modification process | response to organic substance | Rho protein signal transduction | regulation of cellular biosynthetic process | regulation of kinase activity | response to wounding | regulation of intracellular protein kinase cascade | regulation of exocytosis | regulation of multicellular organismal process | cell surface receptor signaling pathway | signal transducer activity | negative regulation of lipid metabolic process | metabolic process | primary metabolic process | regulation of protein catabolic process | regulation of homeostatic process | regulation of body fluid levels | oxidation-reduction process | regulation of vesicle-mediated transport | chemical homeostasis | regulation of secretion | negative regulation of amine transport | cellular response to stimulus | negative regulation of ion transmembrane transporter activity | regulation of epidermal growth factor receptor signaling pathway | negative regulation of biosynthetic process | positive regulation of ion transport | cellular response to endogenous stimulus | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of wound healing | cytoskeleton organization | regulation of ion transmembrane transport | negative regulation of biological process | phospholipase C-activating G-protein coupled receptor signaling pathway | positive regulation of cytokine production | cell activation | regulation of adenylate cyclase activity | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | negative regulation of insulin secretion | signaling | negative regulation of cyclase activity | regulation of ERBB signaling pathway | energy reserve metabolic process | regulation of molecular function | regulation of transmembrane transporter activity | cellular component organization or biogenesis at cellular level | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | cellular protein metabolic process | positive regulation of epidermal growth factor receptor signaling pathway | regulation of cytokine production | positive regulation of response to stimulus | positive regulation of MAP kinase activity | regulation of ion transport | negative regulation of calcium ion-dependent exocytosis | regulation of G-protein coupled receptor protein signaling pathway | energy derivation by oxidation of organic compounds | organelle organization | regulation of calcium ion transport | cellular protein modification process | digestion | regulation of cyclic nucleotide metabolic process | negative regulation of cellular biosynthetic process | positive regulation of cellular process | regulation of transport | adrenergic receptor signaling pathway | Ras protein signal transduction | single-multicellular organism process | single organism signaling | negative regulation of cyclic nucleotide metabolic process | regulation of calcium ion-dependent exocytosis | regulation of transporter activity | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of adrenergic receptor signaling pathway | regulation of calcium ion transmembrane transporter activity | cellular metabolic process | cellular response to organic substance | positive regulation of cell motility | carbohydrate homeostasis | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral to membrane | plasma membrane part | cell | intrinsic to membrane | cytoplasm | receptor complex | macromolecular complex | plasma membrane | membrane part | integral to plasma membrane | cell part | cell periphery | basolateral plasma membrane | intracellular part | intracellular | membrane | protein complex | intrinsic to plasma membrane