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QuickView for ABCB1 (gene)


Gene Symbol:
ABCB1 Homo sapiens Homo sapiens
Full name:
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Synonyms:
MGC163296, MDR1, PGY1, P-glycoprotein 1, P-GP, multidrug resistance protein 1, ABC20, CLCS, colchicin sensitivity, CD243, ATP-binding cassette, sub-family B (MDR/TAP), member 1, ATP-binding cassette, subfamily B, member 1, doxorubicin resistance, GP170
Genomic Location:
Chr 7: 86970884-87180500
Description:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Schizosaccharomyces pombe Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7q21.12


Transcripts Names
NM_000927
Protein Names
Q14812
P08183
Q12755
A4D1D2
A8K294



GO Molecular Function

ATPase activity, coupled to transmembrane movement of substances | ATPase activity, coupled to movement of substances | xenobiotic transporter activity | drug transporter activity | ribonucleotide binding | transmembrane transporter activity | nucleotide binding | hydrolase activity | ATPase activity | pyrophosphatase activity | binding | catalytic activity | ATP binding | P-P-bond-hydrolysis-driven transmembrane transporter activity | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | active transmembrane transporter activity | purine nucleotide binding | transporter activity | organic cyclic compound binding | drug transmembrane transporter activity | nucleoside phosphate binding | purine ribonucleoside triphosphate binding | protein binding | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | primary active transmembrane transporter activity | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | xenobiotic-transporting ATPase activity | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding

GO Biological Process

purine ribonucleotide metabolic process | purine nucleoside triphosphate metabolic process | nucleoside phosphate catabolic process | ATPase activity, coupled to transmembrane movement of substances | establishment of localization | cell cycle phase | response to drug | ATPase activity, coupled to movement of substances | xenobiotic transporter activity | organophosphate catabolic process | drug transporter activity | cellular process | localization | nucleotide metabolic process | carbohydrate derivative catabolic process | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | purine-containing compound catabolic process | catabolic process | transmembrane transporter activity | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | purine ribonucleoside triphosphate metabolic process | response to stimulus | purine nucleotide metabolic process | response to chemical stimulus | transport | heterocycle catabolic process | hydrolase activity | ATPase activity | cellular nitrogen compound metabolic process | pyrophosphatase activity | ribonucleotide catabolic process | cellular catabolic process | nucleobase-containing compound catabolic process | ribonucleoside triphosphate metabolic process | catalytic activity | nitrogen compound metabolic process | P-P-bond-hydrolysis-driven transmembrane transporter activity | cell cycle process | stem cell proliferation | interphase | nucleoside-triphosphatase activity | purine-containing compound metabolic process | cell cycle | organophosphate metabolic process | ATPase activity, coupled | active transmembrane transporter activity | small molecule metabolic process | transporter activity | ATP catabolic process | nucleobase-containing small molecule metabolic process | cell proliferation | purine nucleoside triphosphate catabolic process | G2/M transition of mitotic cell cycle | interphase of mitotic cell cycle | purine ribonucleoside triphosphate catabolic process | nucleotide catabolic process | drug transmembrane transporter activity | cellular nitrogen compound catabolic process | aromatic compound catabolic process | organic cyclic compound catabolic process | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | nucleoside phosphate metabolic process | xenobiotic transport | primary active transmembrane transporter activity | mitotic cell cycle | metabolic process | primary metabolic process | hydrolase activity, acting on acid anhydrides | nucleobase-containing compound metabolic process | organic substance metabolic process | drug transport | transmembrane transport | nucleoside triphosphate catabolic process | drug transmembrane transport | xenobiotic-transporting ATPase activity | carbohydrate derivative metabolic process | heterocycle metabolic process | purine ribonucleotide catabolic process | ribonucleoside triphosphate catabolic process | cellular metabolic process | ATP metabolic process | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | purine nucleotide catabolic process

GO Cellular Component

integral to membrane | intracellular membrane-bounded organelle | plasma membrane part | apical plasma membrane | organelle membrane | cell | intrinsic to membrane | Golgi apparatus part | cytoplasm | intercellular canaliculus | intracellular organelle | apical part of cell | cell-cell junction | Golgi apparatus | endomembrane system | plasma membrane | organelle part | intracellular organelle part | membrane part | cell part | Golgi membrane | membrane-bounded organelle | organelle | cell periphery | cytoplasmic part | cell surface | intracellular part | intracellular | cell junction | membrane