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QuickView for ABCB11 (gene)


Gene Symbol:
ABCB11 Homo sapiens Homo sapiens
Full name:
ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms:
PFIC-2, PFIC2, PGY4, ABC16, BRIC2, BSEP, ATP-binding cassette sub-family B member 11, ATP-binding cassette, sub-family B (MDR/TAP), member 11, bile salt export pump, ABC member 16, MDR/TAP subfamily, sister p-glycoprotein, progressive familial intrahepatic cholestasis 2, SPGP
Genomic Location:
Chr 2: 169487695-169596079
Description:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/...
Orthologs:
Mus musculus Rattus norvegicus Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 2
2q24


Transcripts Names
NM_003742
Protein Names
Q53TL2
Q9UNB2
O95342



GO Molecular Function

bile acid transmembrane transporter activity | ATPase activity, coupled to transmembrane movement of substances | ATPase activity, coupled to movement of substances | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | ribonucleotide binding | transmembrane transporter activity | nucleotide binding | hydrolase activity | organic acid transmembrane transporter activity | ATPase activity | pyrophosphatase activity | binding | catalytic activity | ATP binding | P-P-bond-hydrolysis-driven transmembrane transporter activity | adenyl nucleotide binding | nucleoside-triphosphatase activity | cation transmembrane transporter activity | ATPase activity, coupled | active transmembrane transporter activity | purine nucleotide binding | transporter activity | ion transmembrane transporter activity | substrate-specific transmembrane transporter activity | sodium-exporting ATPase activity, phosphorylative mechanism | organic cyclic compound binding | bile acid-exporting ATPase activity | carboxylic acid transmembrane transporter activity | nucleoside phosphate binding | canalicular bile acid transmembrane transporter activity | purine ribonucleoside triphosphate binding | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | metal ion transmembrane transporter activity | primary active transmembrane transporter activity | hydrolase activity, acting on acid anhydrides | monocarboxylic acid transmembrane transporter activity | sodium ion transmembrane transporter activity | substrate-specific transporter activity | ATPase activity, coupled to transmembrane movement of ions | inorganic cation transmembrane transporter activity | purine ribonucleotide binding | monovalent inorganic cation transmembrane transporter activity | adenyl ribonucleotide binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding

GO Biological Process

small molecule biosynthetic process | bile acid transmembrane transporter activity | purine ribonucleotide metabolic process | purine nucleoside triphosphate metabolic process | carboxylic acid biosynthetic process | nucleoside phosphate catabolic process | ATPase activity, coupled to transmembrane movement of substances | organic cyclic compound biosynthetic process | establishment of localization | ATPase activity, coupled to movement of substances | organophosphate catabolic process | bile acid biosynthetic process | cellular process | monocarboxylic acid transport | localization | nucleotide metabolic process | metal ion transport | carbohydrate derivative catabolic process | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | purine-containing compound catabolic process | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | catabolic process | transmembrane transporter activity | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | steroid biosynthetic process | canalicular bile acid transport | purine ribonucleoside triphosphate metabolic process | oxoacid metabolic process | purine nucleotide metabolic process | monocarboxylic acid metabolic process | transport | heterocycle catabolic process | hydrolase activity | organic acid transmembrane transporter activity | ATPase activity | cellular nitrogen compound metabolic process | pyrophosphatase activity | ribonucleotide catabolic process | cellular biosynthetic process | cellular catabolic process | nucleobase-containing compound catabolic process | ribonucleoside triphosphate metabolic process | catalytic activity | nitrogen compound metabolic process | P-P-bond-hydrolysis-driven transmembrane transporter activity | lipid metabolic process | ion transmembrane transport | nucleoside-triphosphatase activity | purine-containing compound metabolic process | organic substance transport | sodium ion transport | cation transmembrane transporter activity | organophosphate metabolic process | ATPase activity, coupled | monovalent inorganic cation transport | active transmembrane transporter activity | small molecule metabolic process | transporter activity | ATP catabolic process | organic acid transport | ion transmembrane transporter activity | nucleobase-containing small molecule metabolic process | cellular ketone metabolic process | biosynthetic process | purine nucleoside triphosphate catabolic process | purine ribonucleoside triphosphate catabolic process | lipid biosynthetic process | nucleotide catabolic process | substrate-specific transmembrane transporter activity | sodium-exporting ATPase activity, phosphorylative mechanism | bile acid-exporting ATPase activity | carboxylic acid transmembrane transporter activity | cellular nitrogen compound catabolic process | aromatic compound catabolic process | canalicular bile acid transmembrane transporter activity | organic cyclic compound catabolic process | carboxylic acid metabolic process | bile acid metabolic process | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | nucleoside phosphate metabolic process | metal ion transmembrane transporter activity | primary active transmembrane transporter activity | metabolic process | primary metabolic process | bile acid and bile salt transport | hydrolase activity, acting on acid anhydrides | nucleobase-containing compound metabolic process | sodium ion transmembrane transport | organic substance metabolic process | monocarboxylic acid transmembrane transporter activity | sodium ion transmembrane transporter activity | substrate-specific transporter activity | steroid metabolic process | ATPase activity, coupled to transmembrane movement of ions | transmembrane transport | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | nucleoside triphosphate catabolic process | organic acid metabolic process | carboxylic acid transport | cation transport | carbohydrate derivative metabolic process | organic acid biosynthetic process | heterocycle metabolic process | purine ribonucleotide catabolic process | ion transport | ribonucleoside triphosphate catabolic process | cellular metabolic process | ATP metabolic process | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | purine nucleotide catabolic process

GO Cellular Component

integral to membrane | intracellular membrane-bounded organelle | plasma membrane part | apical plasma membrane | organelle membrane | cell | intrinsic to membrane | Golgi apparatus part | cytoplasm | intercellular canaliculus | intracellular organelle | apical part of cell | cell-cell junction | Golgi apparatus | endomembrane system | plasma membrane | organelle part | intracellular organelle part | membrane part | integral to plasma membrane | cell part | Golgi membrane | membrane-bounded organelle | organelle | cell periphery | cytoplasmic part | intracellular part | intracellular | cell junction | membrane | intrinsic to plasma membrane