1 to 7 of 7 literature results

• The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies.

  Gene therapy is a promising therapeutic strategy for genetic and acquired hematologic diseases. With the improvements in gene transfer and expression,…

  Authors: Catia Traversari, Sarah Marktel, Zulma Magnani, Patrizia Mangia, Vincenzo Russo, Fabio Ciceri, Chiara Bonini, Claudio Bordignon

  Source: Blood. 2007 Jun 1

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• Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation.

  The extensive exploitation of the antitumor effect of donor lymphocytes infused after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) i…

  Authors: Fabio Ciceri, Chiara Bonini, Sarah Marktel, Elisabetta Zappone, Paolo Servida, Massimo Bernardi, Alessandra Pescarollo, Attilio Bondanza, Jacopo Peccatori, Silvano Rossini,…

  Source: Blood. 2007 Jun 1

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• Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes.

  In allogeneic hematopoietic cell transplantation (allo-HCT), the immune recognition of host antigens by donor T lymphocytes leads to a beneficial graf…

  Authors: Attilio Bondanza, Veronica Valtolina, Zulma Magnani, Maurilio Ponzoni, Katharina Fleischhauer, Mark Bonyhadi, Catia Traversari, Francesca Sanvito, Salvatore Toma, Marina Radrizzani,…

  Source: Blood. 2006 Mar 1

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• Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence.

  Gene transfer into T lymphocytes is currently being tested for the treatment of lymphohematologic disorders. We previously showed that suicide gene tr…

  Authors: Simona Cavalieri, Sabrina Cazzaniga, Massimo Geuna, Zulma Magnani, Claudio Bordignon, Luigi Naldini, Chiara Bonini

  Source: Blood. 2003 Jul 15

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• Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation.

  We have previously shown that the infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase (HSV-tk) gene is an efficient too…

  Authors: Sarah Marktel, Zulma Magnani, Fabio Ciceri, Sabrina Cazzaniga, Stanley R Riddell, Catia Traversari, Claudio Bordignon, Chiara Bonini

  Source: Blood. 2003 Feb 15

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• Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.

  BACKGROUND: Procedures to prevent severe graft-versus-host disease (GVHD) delay immune reconstitution secondary to transplants of haploidentical haemo…

  Authors: Fabio Ciceri, Chiara Bonini, Maria Teresa Lupo Stanghellini, Attilio Bondanza, Catia Traversari, Monica Salomoni, Lucia Turchetto, Scialini Colombi, Massimo Bernardi, Jacopo Peccatori,…

  Source: The lancet oncology. 2009 May

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• Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.

  The use of retroviral vectors in gene therapy has raised safety concerns for the genotoxic risk associated with their uncontrolled insertion into the …

  Authors: Alessandra Recchia, Chiara Bonini, Zulma Magnani, Fabrizia Urbinati, Daniela Sartori, Sara Muraro, Enrico Tagliafico, Attilio Bondanza, Maria Teresa Lupo Stanghellini, Massimo Bernardi,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jan 31

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