1 to 10 of 18 literature results

• Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.

  Self-renewing cell populations such as hematopoietic stem cells and memory B and T lymphocytes might be regulated by shared signaling pathways. The Wn…

  Authors: Luca Gattinoni, Xiao-Song Zhong, Douglas C Palmer, Yun Ji, Christian S Hinrichs, Zhiya Yu, Claudia Wrzesinski, Andrea Boni, Lydie Cassard, Lindsay M Garvin,…

  Source: Nature medicine. 2009 Jul

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• Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.

  Naive and memory CD8(+) T cells can undergo programmed activation and expansion in response to a short T-cell receptor stimulus, but the extent to whi…

  Authors: Christopher A Klebanoff, Zhiya Yu, Leroy N Hwang, Douglas C Palmer, Luca Gattinoni, Nicholas P Restifo

  Source: Blood. 2009 Aug 27

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• The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.

  It has been hypothesized that rapidly dividing tumor cells can outpace adoptively transferred antitumor lymphocytes when tumors are large. However, th…

  Authors: Leroy N Hwang, Zhiya Yu, Douglas C Palmer, Nicholas P Restifo

  Source: Cancer research. 2006 Jan 15

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• Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer.

  Immunotherapy using adoptive cell transfer is a promising approach that can result in the regression of bulky, invasive cancer in some patients. Howev…

  Authors: Steven E Finkelstein, David M Heimann, Christopher A Klebanoff, Paul A Antony, Luca Gattinoni, Christian S Hinrichs, Leroy N Hwang, Douglas C Palmer, Paul J Spiess, Deborah R Surman,…

  Source: Journal of leukocyte biology. 2004 Aug

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• Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells.

  PURPOSE: Carcinoembryonic antigen (CEA) is a tumor-associated protein expressed on a variety of adenocarcinomas. To develop an immunotherapy for patie…

  Authors: Maria R Parkhurst, Jayne Joo, John P Riley, Zhiya Yu, Yong Li, Paul F Robbins, Steven A Rosenberg

  Source: Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Jan 1

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• Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.

  Depleting host immune elements with nonmyeloablative regimens prior to the adoptive transfer of tumor-specific CD8(+) T cells significantly enhances t…

  Authors: Claudia Wrzesinski, Chrystal M Paulos, Luca Gattinoni, Douglas C Palmer, Andrew Kaiser, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo

  Source: The Journal of clinical investigation. 2007 Feb

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• Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.

  Lymphodepletion before adoptive cell transfer (ACT)-based immunotherapies can enhance anti-tumor responses by augmenting innate immunity, by increasin…

  Authors: Claudia Wrzesinski, Chrystal M Paulos, Andrew Kaiser, Pawel Muranski, Douglas C Palmer, Luca Gattinoni, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo

  Source: Journal of immunotherapy (Hagerstown, Md. : 1997). 2010 Jan

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• Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

  Effector cells derived from central memory CD8(+) T cells were reported to engraft and survive better than those derived from effector memory populati…

  Authors: Christian S Hinrichs, Zachary A Borman, Lydie Cassard, Luca Gattinoni, Rosanne Spolski, Zhiya Yu, Luis Sanchez-Perez, Pawel Muranski, Steven J Kern, Carol Logun,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Oct 13

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• Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.

  Nonmutated tissue differentiation antigens expressed by tumors are attractive targets for cancer immunotherapy, but the consequences of a highly effec…

  Authors: Douglas C Palmer, Chi-Chao Chan, Luca Gattinoni, Claudia Wrzesinski, Chrystal M Paulos, Christian S Hinrichs, Daniel J Powell, Christopher A Klebanoff, Steven E Finkelstein, Robert N Fariss,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Jun 10

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• Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/MHC complex: implications for vaccine design.

  The use of "anchor-fixed" altered peptide ligands is of considerable interest in the development of therapeutic vaccines for cancer and infectious dis…

  Authors: Oleg Y Borbulevych, Tiffany K Baxter, Zhiya Yu, Nicholas P Restifo, Brian M Baker

  Source: Journal of immunology (Baltimore, Md. : 1950). 2005 Apr 15

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