1 to 10 of 53 literature results

• Ubiquitylation in innate and adaptive immunity.

  Protein ubiquitylation has emerged as a key mechanism that regulates immune responses. Much like phosphorylation, ubiquitylation is a reversible coval…

  Authors: Vijay G Bhoj, Zhijian J Chen

  Source: Nature. 2009 Mar 26

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• The role of ubiquitin in NF-kappaB regulatory pathways.

  Nuclear factor kappa enhancer binding protein (NF-kappaB) regulates diverse biological processes including immunity, inflammation, and apoptosis. A va…

  Authors: Brian Skaug, Xiaomo Jiang, Zhijian J Chen

  Source: Annual review of biochemistry. 2009

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• Linking retroelements to autoimmunity.

  In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuc…

  Authors: Vijay G Bhoj, Zhijian J Chen

  Source: Cell. 2008 Aug 22

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• Nonproteolytic functions of ubiquitin in cell signaling.

  The small protein ubiquitin is a central regulator of a cell's life and death. Ubiquitin is best known for targeting protein destruction by the 26S pr…

  Authors: Zhijian J Chen, Lijun J Sun

  Source: Molecular cell. 2009 Feb 13

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• RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

  Type I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid-induced gene I (RIG-I) and mitochondrial antiviral signa…

  Authors: Yu-Hsin Chiu, John B Macmillan, Zhijian J Chen

  Source: Cell. 2009 Aug 7

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• Direct activation of protein kinases by unanchored polyubiquitin chains.

  TRAF6 is a ubiquitin ligase that is essential for the activation of NF-kappaB and MAP kinases in several signalling pathways, including those emanatin…

  Authors: Zong-Ping Xia, Lijun Sun, Xiang Chen, Gabriel Pineda, Xiaomo Jiang, Anirban Adhikari, Wenwen Zeng, Zhijian J Chen

  Source: Nature. 2009 Sep 3

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• Diversity of polyubiquitin chains.

  Polyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-dependent and -independent functions. In a recent Cell is…

  Authors: Anirban Adhikari, Zhijian J Chen

  Source: Developmental cell. 2009 Apr

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• Ubiquitin signalling in the NF-kappaB pathway.

  The transcription factor NF-kappaB (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apopt…

  Authors: Zhijian J Chen

  Source: Nature cell biology. 2005 Aug

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• MITAgating viral infection.

  Two recent papers, one in this issue of Immunity (Zhong et al., 2008), report the identification of a membrane protein, termed MITA or STING, that act…

  Authors: Wenwen Zeng, Zhijian J Chen

  Source: Immunity. 2008 Oct 17

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• Sorting out Toll signals.

  Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. I…

  Authors: Katherine A Fitzgerald, Zhijian J Chen

  Source: Cell. 2006 Jun 2

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