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USP10 regulates p53 localization and stability by deubiquitinating p53.
Stability and localization of p53 is essential for its tumor suppressor function. Ubiquitination by the E3 ubiquitin ligase Mdm2 is the major regulato…
Authors: Jian Yuan, Kuntian Luo, Lizhi Zhang, John C Cheville, Zhenkun Lou
Source: Cell. 2010 Feb 5
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DBC1 is a negative regulator of SIRT1.
The NAD-dependent protein deacetylase Sir2 (silent information regulator 2) regulates lifespan in several organisms. SIRT1, the mammalian orthologue o…
Authors: Ja-Eun Kim, Junjie Chen, Zhenkun Lou
Source: Nature. 2008 Jan 31
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Topoisomerase IIalpha controls the decatenation checkpoint.
Topoisomerase II (Topo II) is required to separate intertwined sister chromatids before chromosome segregation can occur in mitosis. However, it remai…
Authors: Kuntian Luo, Jian Yuan, Junjie Chen, Zhenkun Lou
Source: Nature cell biology. 2009 Feb
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FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.
Akt is a central regulator of cell growth. Its activity can be negatively regulated by the phosphatase PHLPP that specifically dephosphorylates the hy…
Authors: Huadong Pei, Liang Li, Brooke L Fridley, Gregory D Jenkins, Krishna R Kalari, Wilma Lingle, Gloria Petersen, Zhenkun Lou, Liewei Wang
Source: Cancer cell. 2009 Sep 8
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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.
Forkhead-homology-associated (FHA) domains function as protein-protein modules that recognize phosphorylated serine/threonine motifs. Interactions bet…
Authors: Zhenkun Lou, Katherine Minter-Dykhouse, Xianglin Wu, Junjie Chen
Source: Nature. 2003 Feb 27
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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.
MDC1 functions in checkpoint activation and DNA repair following DNA damage. To address the physiological role of MDC1, we disrupted the MDC1 gene in …
Authors: Zhenkun Lou, Katherine Minter-Dykhouse, Sonia Franco, Monica Gostissa, Melissa A Rivera, Arkady Celeste, John P Manis, Jan van Deursen, André Nussenzweig, Tanya T Paull,…
Source: Molecular cell. 2006 Jan 20
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H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.
Histone H2AX promotes DNA double-strand break (DSB) repair and immunoglobulin heavy chain (IgH) class switch recombination (CSR) in B-lymphocytes. CSR…
Authors: Sonia Franco, Monica Gostissa, Shan Zha, David B Lombard, Michael M Murphy, Ali A Zarrin, Catherine Yan, Suprawee Tepsuporn, Julio C Morales, Melissa M Adams,…
Source: Molecular cell. 2006 Jan 20
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Cellular senescence and DNA repair.
Aging is a complex process that results in functional decline and mortality of the organisms. On the cellular lever, cellular senescence has been used…
Authors: Zhenkun Lou, Junjie Chen
Source: Experimental cell research. 2006 Aug 15
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Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines.
Resistance to temozolomide and radiotherapy is a major problem for patients with glioblastoma but may be overcome using the poly(ADP-ribose) polymeras…
Authors: Michelle J Clarke, Evan A Mulligan, Patrick T Grogan, Ann C Mladek, Brett L Carlson, Mark A Schroeder, Nicola J Curtin, Zhenkun Lou, Paul A Decker, Wenting Wu,…
Source: Molecular cancer therapeutics. 2009 Feb
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Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1.
In male germ cells the repair of DNA double strand breaks (DSBs) differs from that described for somatic cell lines. Irradiation induced immunofluores…
Authors: Emad A Ahmed, Aniek van der Vaart, Angeliqué Barten, Henk B Kal, Junjie Chen, Zhenkun Lou, Katherine Minter-Dykhouse, Jirina Bartkova, Jiri Bartek, Peter de Boer,…
Source: DNA repair. 2007 Sep 1
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