1 to 10 of 16 literature results

• ETS rearrangements and prostate cancer initiation.

  The first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation …

  Authors: Brett S Carver, Jennifer Tran, Zhenbang Chen, Arkaitz Carracedo-Perez, Andrea Alimonti, Caterina Nardella, Anuradha Gopalan, Peter T Scardino, Carlos Cordon-Cardo, William Gerald,…

  Source: Nature. 2009 Feb 12

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• Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.

  Chromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant…

  Authors: Brett S Carver, Jennifer Tran, Anuradha Gopalan, Zhenbang Chen, Safa Shaikh, Arkaitz Carracedo, Andrea Alimonti, Caterina Nardella, Shohreh Varmeh, Peter T Scardino,…

  Source: Nature genetics. 2009 May

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• Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.

  Tuberous sclerosis (TSC) is a tumor syndrome caused by mutation in TSC1 or TSC2 genes. TSC tumorigenesis is not always accompanied by loss of heterozy…

  Authors: Li Ma, Zhenbang Chen, Hediye Erdjument-Bromage, Paul Tempst, Pier Paolo Pandolfi

  Source: Cell. 2005 Apr 22

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• Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.

  Skp2 is an F-box protein that forms the SCF complex with Skp1 and Cullin-1 to constitute an E3 ligase for ubiquitylation. Ubiquitylation and degradati…

  Authors: Hui-Kuan Lin, Guocan Wang, Zhenbang Chen, Julie Teruya-Feldstein, Yan Liu, Chia-Hsin Chan, Wei-Lei Yang, Hediye Erdjument-Bromage, Keiichi I Nakayama, Stephen Nimer,…

  Source: Nature cell biology. 2009 Apr

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• Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.

  The mammalian target of rapamycin (mTOR) represents a critical signaling crossroad where pathways commonly disrupted in cancer converge. We report her…

  Authors: Caterina Nardella, Zhenbang Chen, Leonardo Salmena, Arkaitz Carracedo, Andrea Alimonti, Ainara Egia, Brett Carver, William Gerald, Carlos Cordon-Cardo, Pier Paolo Pandolfi

  Source: Genes & development. 2008 Aug 15

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• NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.

  The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle red…

  Authors: Xinjiang Wang, Lloyd C Trotman, Theresa Koppie, Andrea Alimonti, Zhenbang Chen, Zhonghua Gao, Junru Wang, Hediye Erdjument-Bromage, Paul Tempst, Carlos Cordon-Cardo,…

  Source: Cell. 2007 Jan 12

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• Ubiquitination regulates PTEN nuclear import and tumor suppression.

  The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden s…

  Authors: Lloyd C Trotman, Xinjiang Wang, Andrea Alimonti, Zhenbang Chen, Julie Teruya-Feldstein, Haijuan Yang, Nikola P Pavletich, Brett S Carver, Carlos Cordon-Cardo, Hediye Erdjument-Bromage,…

  Source: Cell. 2007 Jan 12

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• Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.

  Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro, but the relevance o…

  Authors: Zhenbang Chen, Lloyd C Trotman, David Shaffer, Hui-Kuan Lin, Zohar A Dotan, Masaru Niki, Jason A Koutcher, Howard I Scher, Thomas Ludwig, William Gerald,…

  Source: Nature. 2005 Aug 4

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• Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.

  The role of tumor suppressor haploinsufficiency in oncogenesis is still poorly understood. The PTEN and TSC2 tumor suppressors function to antagonize …

  Authors: Li Ma, Julie Teruya-Feldstein, Nille Behrendt, Zhenbang Chen, Tetsuo Noda, Okio Hino, Carlos Cordon-Cardo, Pier Paolo Pandolfi

  Source: Genes & development. 2005 Aug 1

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• Comparative physical mapping of the apospory-specific genomic region in two apomictic grasses: Pennisetum squamulatum and Cenchrus ciliaris.

  In gametophytic apomicts of the aposporous type, each cell of the embryo sac is genetically identical to somatic cells of the ovule because they are p…

  Authors: Shailendra Goel, Zhenbang Chen, Yukio Akiyama, Joann A Conner, Manojit Basu, Gustavo Gualtieri, Wayne W Hanna, Peggy Ozias-Akins

  Source: Genetics. 2006 May

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