Click on one of these terms to refine your search
1 to 4 of 4 literature results
-
Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats.
Starting from a known piperazine-based SCD-1 inhibitor, we obtained more potent benzoylpiperidine analogs. Optimization of the structure of the benzoy…
Authors: Yoshikazu Uto, Tsuneaki Ogata, Yohei Kiyotsuka, Yuko Ueno, Yuriko Miyazawa, Hitoshi Kurata, Tsuneo Deguchi, Nobuaki Watanabe, Masahiro Konishi, Ryo Okuyama,…
Source: Bioorganic & medicinal chemistry letters. 2009 Oct 29
View Full Text -
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.
A series of structurally novel stearoyl-CoA desaturase-1 (SCD-1) inhibitors has been identified by optimizing a hit from our corporate library. Prelim…
Authors: Yoshikazu Uto, Tsuneaki Ogata, Jun Harada, Yohei Kiyotsuka, Yuko Ueno, Yuriko Miyazawa, Hitoshi Kurata, Tsuneo Deguchi, Nobuaki Watanabe, Toshiyuki Takagi,…
Source: Bioorganic & medicinal chemistry letters. 2009 Aug 1
View Full Text -
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.
The continuing investigation of SAR studies of 3-(2-hydroxyethoxy)-N-(5-benzylthiazol-2-yl)-benzamides as stearoyl-CoA desaturase-1 (SCD-1) inhibitors…
Authors: Yoshikazu Uto, Tsuneaki Ogata, Yohei Kiyotsuka, Yuriko Miyazawa, Yuko Ueno, Hitoshi Kurata, Tsuneo Deguchi, Makiko Yamada, Nobuaki Watanabe, Toshiyuki Takagi,…
Source: Bioorganic & medicinal chemistry letters. 2009 Aug 1
View Full Text -
Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite.
Quinazolinone type alkaloids, febrifugine (1) and isofebrifugine (2), isolated from Dichroa febrifuga roots, show powerful antimalarial activity again…
Authors: Shingo Hirai, Haruhisa Kikuchi, Hye-Sook Kim, Khurshida Begum, Yusuke Wataya, Hidehisa Tasaka, Yuriko Miyazawa, Keisuke Yamamoto, Yoshiteru Oshima
Source: Journal of medicinal chemistry. 2003 Sep 25
View Full Text
