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Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes.
Nuclear pore complexes have recently been shown to play roles in gene activation; however their potential involvement in metazoan transcription remain…
Authors: Maya Capelson, Yun Liang, Roberta Schulte, William Mair, Ulrich Wagner, Martin W Hetzer
Source: Cell. 2010 Feb 5
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Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover.
SRC-3/AIB1 is a master growth coactivator and oncogene, and phosphorylation activates it into a powerful coregulator. Dephosphorylation is a potential…
Authors: Chao Li, Yao-Yun Liang, Xin-Hua Feng, Sophia Y Tsai, Ming-Jer Tsai, Bert W O'Malley
Source: Molecular cell. 2008 Sep 26
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PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.
TGFbeta signaling controls diverse normal developmental processes and pathogenesis of diseases including cancer and autoimmune and fibrotic diseases. …
Authors: Xia Lin, Xueyan Duan, Yao-Yun Liang, Ying Su, Katharine H Wrighton, Jianyin Long, Min Hu, Candi M Davis, Jinrong Wang, F Charles Brunicardi,…
Source: Cell. 2006 Jun 2
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Distinct roles for CARMIL isoforms in cell migration.
Molecular mechanisms for cell migration, especially how signaling and cytoskeletal systems are integrated, are not understood well. Here, we examined …
Authors: Yun Liang, Hanspeter Niederstrasser, Marc Edwards, Charles E Jackson, John A Cooper
Source: Molecular biology of the cell. 2009 Dec
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Smad7-induced beta-catenin degradation alters epidermal appendage development.
To assess whether Smad signaling affects skin development, we generated transgenic mice in which a Smad antagonist, Smad7, was induced in keratinocyte…
Authors: Gangwen Han, Allen G Li, Yao-Yun Liang, Philip Owens, Wei He, Shilong Lu, Yasuhiro Yoshimatsu, Donna Wang, Peter Ten Dijke, Xia Lin,…
Source: Developmental cell. 2006 Sep
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Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B).
The c-Myc oncogene has been implicated in the genesis of diverse human tumors. Ectopic expression of the c-Myc gene in cultured epithelial cells cause…
Authors: Xin-Hua Feng, Yao-Yun Liang, Min Liang, Weiguo Zhai, Xia Lin
Source: Molecular cell. 2002 Jan
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Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.
The transcription corepressor CtBP is often recruited to the target promoter via interaction with a conserved PxDLS motif in the interacting repressor…
Authors: Xia Lin, Baohua Sun, Min Liang, Yao-Yun Liang, Andreas Gast, Jeffrey Hildebrand, F Charles Brunicardi, Frauke Melchior, Xin-Hua Feng
Source: Molecular cell. 2003 May
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Developing DCE-CT to quantify intra-tumor heterogeneity in breast tumors with differing angiogenic phenotype.
The objective of this study is to evaluate the ability of dynamic contrast enhanced computed tomography (DCE-CT) to assess intratumor physiological he…
Authors: Minsong Cao, Yun Liang, Changyu Shen, Kathy D Miller, Keith M Stantz
Source: IEEE transactions on medical imaging. 2009 Jun
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Palladium-catalyzed decarboxylative coupling of allylic alkynoates with arynes.
A novel and selective protocol for the synthesis of 1-allyl-2-ethynylbenzenes has been developed by palladium-catalyzed decarboxylative coupling of al…
Authors: Shao-Feng Pi, Bo-Xiao Tang, Jin-Heng Li, Yi-Lin Liu, Yun Liang
Source: Organic letters. 2009 Jun 4
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The correspondence between coronary arterial wall strain and histology in a porcine model of atherosclerosis.
Atherosclerotic plaque rupture is the leading cause of mortality in cardiovascular disease. Intravascular ultrasound (IVUS) imaging is a powerful clin…
Authors: Yun Liang, Hui Zhu, Morton H Friedman
Source: Physics in medicine and biology. 2009 Sep 21
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