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Practical application to time indicator of a novel white film formed by interaction of calcium salts with hydroxypropyl methylcellulose.
We have found that a cast film forms a white film when an aqueous solution comprising hydroxypropyl methylcellulose (HPMC) and calcium salts such as c…
Authors: Sumihiro Shiraishi, Yukoh Sakata, Hiroyuki Yamaguchi
Source: International journal of pharmaceutics. 2010 Jan 4
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Evaluation of relationship between molecular behaviour and mechanical strength of pullulan films.
This study aimed to investigate the relationship between the physical properties and molecular behaviour of pullulan films. To study its thermal behav…
Authors: Yukoh Sakata, Makoto Otsuka
Source: International journal of pharmaceutics. 2009 Jun 5
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A novel white film for pharmaceutical coating formed by interaction of calcium lactate pentahydrate with hydroxypropyl methylcellulose.
We have found that a white film forms on tablets when a coating solution consisting of hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG …
Authors: Yukoh Sakata, Sumihiro Shiraishi, Makoto Otsuka
Source: International journal of pharmaceutics. 2006 Jul 24
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Effects of solid-state reaction between paracetamol and cloperastine hydrochloride on the pharmaceutical properties of their preparations.
Tablets containing both paracetamol (PM) and cloperastine hydrochloride (CLH) in a combination formulation prepared by standard vertical granulation t…
Authors: Yukoh Sakata, Eishi Tanabe, Toshiharu Sumikawa, Sumihiro Shiraishi, Yoshihiro Tokudome, Makoto Otsuka
Source: International journal of pharmaceutics. 2007 Apr 20
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Effect of dehydration and urea on stability of homosulfamine in solid states.
In the presence of urea in solid states, the stability of unpulverized homosulfamine hydrate (phase I; UHH) is significantly decreased whereas that of…
Authors: Shiho Kanou, Katsunori Nishimura, Makoto Ichikawa, Jirou Yoshida, Yukoh Sakata, Makoto Otsuka
Source: Drug development and industrial pharmacy. 2008 Jul
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Effect of pulverization and dehydration on the pharmaceutical properties of calcium lactate pentahydrate tablets.
The effects of heat conduction and pulverization on dehydration kinetics and tablet hardness were studied by a variety of kinetic equations and physic…
Authors: Yukoh Sakata, Sumihiro Shiraishi, Kozo Takayama, Makoto Otsuka
Source: Colloids and surfaces. B, Biointerfaces. 2006 Aug 15
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Effect of pulverization of the bulk powder on the hydration of creatine anhydrate tablets and their pharmaceutical properties.
The hydration behavior and expansion properties of untreated and pulverized creatine anhydrate (CRA) tablets were studied under 60 and 75%RH at 25 deg…
Authors: Yukoh Sakata, Sumihiro Shiraishi, Makoto Otsuka
Source: Colloids and surfaces. B, Biointerfaces. 2005 Dec 10
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Effect of tablet geometrical structure on the dehydration of creatine monohydrate tablets, and their pharmaceutical properties.
The effects of compression and pulverization on the dehydration kinetics and hardness of creatine monohydrate tablets were studied using a variety of …
Authors: Yukoh Sakata, Sumihiro Shiraishi, Makoto Otsuka
Source: AAPS PharmSciTech. 2005
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Characterization of dehydration and hydration behavior of calcium lactate pentahydrate and its anhydrate.
The use of calcium lactate pentahydrate (CLP) as an additional filler-binder for direct compaction of tablets has been reported to result in a short d…
Authors: Yukoh Sakata, Sumihiro Shiraishi, Makoto Otsuka
Source: Colloids and surfaces. B, Biointerfaces. 2005 Dec 20
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Characterization of dehydration behavior of untreated and pulverized creatine monohydrate powders.
Creatine, which is well known as an important substance for muscular activity, is synthesized from amino acids such as glycine, arginine and ornithine…
Authors: Yukoh Sakata, Sumihiro Shiraishi, Makoto Otsuka
Source: Colloids and surfaces. B, Biointerfaces. 2004 Jun 1
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