1 to 10 of 30 literature results

• Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.

  Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), w…

  Authors: Vidyullatha Vasireddy, Yoshikazu Uchida, Norman Salem, Soo Yeon Kim, Md Nawajesh Ali Mandal, Geereddy Bhanuprakash Reddy, Ravi Bodepudi, Nathan L Alderson, Johnie C Brown, Hiroko Hama,…

  Source: Human molecular genetics. 2007 Mar 1

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• Omega-O-acylceramide, a lipid essential for mammalian survival.

  The prevention of water loss through the skin is critical for terrestrial mammalian species. This function is served by the epidermal permeability bar…

  Authors: Yoshikazu Uchida, Walter M Holleran

  Source: Journal of dermatological science. 2008 Aug

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• Epidermal sphingolipids: metabolism, function, and roles in skin disorders.

  Mammalian epidermis produces and delivers large quantities of glucosylceramide and sphingomyelin precursors to stratum corneum extracellular domains, …

  Authors: Walter M Holleran, Yutaka Takagi, Yoshikazu Uchida

  Source: FEBS letters. 2006 Oct 9

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• Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells.

  Treatment with doxorubicin (DOX) induced apoptosis with an increase of ceramide content in drug-sensitive HL-60 cells, but not in drug-resistant HL-60…

  Authors: Yoshikazu Uchida, Mitsuru Itoh, Yoshimitsu Taguchi, Syohei Yamaoka, Hisanori Umehara, Shin-Ichi Ichikawa, Yoshio Hirabayashi, Walter M Holleran, Toshiro Okazaki

  Source: Cancer research. 2004 Sep 1

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• On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides.

  BACKGROUND: Ceramides (Cer) in the stratum corneum are essential for epidermal permeability barrier function. Thus, topical Cer replacement therapy ha…

  Authors: Yoshikazu Uchida, Walter M Holleran, Peter M Elias

  Source: Journal of dermatological science. 2008 Jul

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• Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman-Chanarin syndrome.

  BACKGROUND: Dorfman-Chanarin syndrome (DCS), also referred to as neutral lipid storage disease with ichthyosis, is a rare autosomal recessive form of …

  Authors: Mayumi Ujihara, Kimiko Nakajima, Mayuko Yamamoto, Mika Teraishi, Yoshikazu Uchida, Masashi Akiyama, Hiroshi Shimizu, Shigetoshi Sano

  Source: Journal of dermatological science. 2010 Feb

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• Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis.

  Ceramides (Cers) accumulate within the interstices of the outermost epidermal layers, or stratum corneum (SC), where they represent critical component…

  Authors: Evi Houben, Walter M Holleran, Toshiaki Yaginuma, Cungui Mao, Lina M Obeid, Vera Rogiers, Yutaka Takagi, Peter M Elias, Yoshikazu Uchida

  Source: Journal of lipid research. 2006 May

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• Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity.

  Defective transglutaminase 1 (TGM1) is a causative factor in some cases of lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE) de…

  Authors: Robert H Rice, Debra Crumrine, Yoshikazu Uchida, Robert Gruber, Peter M Elias

  Source: Archives of dermatological research. 2005 Sep

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• Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators.

  BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory dermatosis now increasingly linked to mutations that alter the structure and function of …

  Authors: Yutaka Hatano, Mao-Qiang Man, Yoshikazu Uchida, Debra Crumrine, Theodora M Mauro, Kenneth R Feingold, Peter M Elias, Walter M Holleran

  Source: The Journal of allergy and clinical immunology. 2010 Jan

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• Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress.

  Ceramides (Cers), critical for epidermal barrier function, also can inhibit keratinocyte proliferation, while glucosylceramides (GlcCers) exert pro-mi…

  Authors: Yoshikazu Uchida, Satoru Murata, Matthias Schmuth, Martin J Behne, Jeong Deuk Lee, Shinichi Ichikawa, Peter M Elias, Yoshio Hirabayashi, Walter M Holleran

  Source: Journal of lipid research. 2002 Aug

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