1 to 6 of 6 literature results

• Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism.

  Brown fat is specialized for energy expenditure, a process that is principally controlled by the transcriptional coactivator PGC-1alpha. Here, we desc…

  Authors: Dongning Pan, Masaki Fujimoto, Andrea Lopes, Yong-Xu Wang

  Source: Cell. 2009 Apr 3

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• PPARs and the complex journey to obesity.

  Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, t…

  Authors: Ronald M Evans, Grant D Barish, Yong-Xu Wang

  Source: Nature medicine. 2004 Apr

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• AMPK and PPARdelta agonists are exercise mimetics.

  The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of …

  Authors: Vihang A Narkar, Michael Downes, Ruth T Yu, Emi Embler, Yong-Xu Wang, Ester Banayo, Maria M Mihaylova, Michael C Nelson, Yuhua Zou, Henry Juguilon,…

  Source: Cell. 2008 Aug 8

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• Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity.

  In contrast to the well-established roles of PPARgamma and PPARalpha in lipid metabolism, little is known for PPARdelta in this process. We show here …

  Authors: Yong-Xu Wang, Chih-Hao Lee, Sambath Tiep, Ruth T Yu, Jungyeob Ham, Heonjoong Kang, Ronald M Evans

  Source: Cell. 2003 Apr 18

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• PPARs: diverse regulators in energy metabolism and metabolic diseases.

  The nuclear receptor PPARs are fundamentally important for energy homeostasis. Through their distinct yet overlapping functions and tissue distributio…

  Authors: Yong-Xu Wang

  Source: Cell research. 2010 Feb

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• Regulation of muscle fiber type and running endurance by PPARdelta.

  Endurance exercise training can promote an adaptive muscle fiber transformation and an increase of mitochondrial biogenesis by triggering scripted cha…

  Authors: Yong-Xu Wang, Chun-Li Zhang, Ruth T Yu, Helen K Cho, Michael C Nelson, Corinne R Bayuga-Ocampo, Jungyeob Ham, Heonjoong Kang, Ronald M Evans

  Source: PLoS biology. 2004 Oct

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