1 to 10 of 16 literature results

• Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression.

  The naturally occurring regulatory T cell (T(r)) is the pivotal cell type that maintains self-tolerance and exerts active immune suppression. The deve…

  Authors: Yisong Y Wan, Richard A Flavell

  Source: Nature. 2007 Feb 15

  View Full Text

• Transforming growth factor-beta regulation of immune responses.

  Transforming growth factor-beta (TGF-beta) is a potent regulatory cytokine with diverse effects on hemopoietic cells. The pivotal function of TGF-beta…

  Authors: Ming O Li, Yisong Y Wan, Shomyseh Sanjabi, Anna-Karin L Robertson, Richard A Flavell

  Source: Annual review of immunology. 2006

  View Full Text

• The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function.

  The kinase TAK1 is critical for innate and B cell immunity. The function of TAK1 in T cells is unclear, however. We show here that T cell-specific del…

  Authors: Yisong Y Wan, Hongbo Chi, Min Xie, Michael D Schneider, Richard A Flavell

  Source: Nature immunology. 2006 Aug

  View Full Text

• T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.

  TGF-beta1 is a regulatory cytokine with a pleiotropic role in immune responses. TGF-beta1 is widely expressed in leukocytes and stromal cells. However…

  Authors: Ming O Li, Yisong Y Wan, Richard A Flavell

  Source: Immunity. 2007 May

  View Full Text

• The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression.

  We have explored the interactions between the NFkappaB and Cdk-Rb-E2F pathways in controlling T cell fate following antigen stimulation. The inhibitio…

  Authors: Yisong Y Wan, James DeGregori

  Source: Immunity. 2003 Mar

  View Full Text

• Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation.

  Transforming growth factor-beta (TGF-beta) and forkhead box p3-expressing T-regulatory (Treg) cells are critical in maintaining self-tolerance and imm…

  Authors: Yisong Y Wan, Richard A Flavell

  Source: Immunological reviews. 2007 Dec

  View Free Full Text

• Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse.

  To identify interleukin-10 (IL-10)-producing cells in vivo, we generated a knockin mouse where an internal ribosome entry site (IRES) green fluorescen…

  Authors: Masahito Kamanaka, Sean T Kim, Yisong Y Wan, Fayyaz S Sutterwala, Maria Lara-Tejero, Jorge E Galán, Ed Harhaj, Richard A Flavell

  Source: Immunity. 2006 Dec

  View Full Text

• The roles for cytokines in the generation and maintenance of regulatory T cells.

  As an essential mechanism for self-tolerance, immune suppression has attracted much attention since the discovery of suppressor T cells, now called re…

  Authors: Yisong Y Wan, Richard A Flavell

  Source: Immunological reviews. 2006 Aug

  View Full Text

• TGF-beta and regulatory T cell in immunity and autoimmunity.

  INTRODUCTION: The immune response is controlled by several inhibitory mechanisms. These mechanisms include regulatory T cells, which exist in multiple…

  Authors: Yisong Y Wan, Richard A Flavell

  Source: Journal of clinical immunology. 2008 Nov

  View Full Text

• Chromatin remodeling complex in Treg function.

  Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of T…

  Authors: Anant Jani, Tian Chi, Yisong Y Wan

  Source: International immunopharmacology. 2009 May

  View Full Text