1 to 5 of 5 literature results

• Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats.

  Most patients with diabetes die from cardiac or arterial disease, for which there are limited therapeutic options. Free Cu(2+) ions are strongly pro-o…

  Authors: Deming Gong, Jun Lu, Xiuyin Chen, Soon Y Choong, Shaoping Zhang, Yih-Kai Chan, Sarah Glyn-Jones, Gregory D Gamble, Anthony R J Phillips, Garth J S Cooper

  Source: Molecular pharmacology. 2006 Dec

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• Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals.

  We recently showed that treatment with the Cu(II)-selective chelator, trientine, alleviates heart failure in diabetic rats, improves left ventricular …

  Authors: Garth J S Cooper, Yih-Kai Chan, Ajith M Dissanayake, Fiona E Leahy, Geraldine F Keogh, Chris M Frampton, Gregory D Gamble, Dianne H Brunton, John R Baker, Sally D Poppitt

  Source: Diabetes. 2005 May

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• Regeneration of the heart in diabetes by selective copper chelation.

  Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Although al…

  Authors: Garth J S Cooper, Anthony R J Phillips, Soon Y Choong, Bridget L Leonard, David J Crossman, Dianne H Brunton, 'Etuate L Saafi, Ajith M Dissanayake, Brett R Cowan, Alistair A Young,…

  Source: Diabetes. 2004 Sep

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• Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load.

  OBJECTIVE: Circulating levels of adiponectin are low in obesity and metabolic disorders associated with increasing fat mass including insulin resistan…

  Authors: Sally D Poppitt, Geraldine F Keogh, Fiona E Lithander, Yu Wang, Tom B Mulvey, Yih-Kai Chan, Brian H McArdle, Garth J S Cooper

  Source: Nutrition (Burbank, Los Angeles County, Calif.). 2008 Apr

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• No evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks.

  OBJECTIVE: Little is known about the effects of alterations in fatty acid classes on adiponectin, a hormone secreted by the adipocyte known to be impo…

  Authors: Fiona E Lithander, Geraldine F Keogh, Yu Wang, Garth J S Cooper, Tom B Mulvey, Yih-Kai Chan, Brian H McArdle, Sally D Poppitt

  Source: Obesity (Silver Spring, Md.). 2008 Mar

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