1 to 10 of 14 literature results

• Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization.

  Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 c…

  Authors: Xin Ye, Yanshu Wang, Hugh Cahill, Minzhong Yu, Tudor C Badea, Philip M Smallwood, Neal S Peachey, Jeremy Nathans

  Source: Cell. 2009 Oct 16

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• Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.

  Craniorachischisis is a rare but severe birth defect that results in a completely open neural tube. Mouse mutants in planar cell polarity (PCP) signal…

  Authors: Janna Merte, Devon Jensen, Kevin Wright, Sarah Sarsfield, Yanshu Wang, Randy Schekman, David D Ginty

  Source: Nature cell biology. 2010 Jan

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• Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

  Incomplete retinal vascularization occurs in both Norrie disease and familial exudative vitreoretinopathy (FEVR). Norrin, the protein product of the N…

  Authors: Qiang Xu, Yanshu Wang, Alain Dabdoub, Philip M Smallwood, John Williams, Chad Woods, Matthew W Kelley, Li Jiang, William Tasman, Kang Zhang,…

  Source: Cell. 2004 Mar 19

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• Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia.

  Planar cell polarity (PCP) signaling polarises cells along tissue axes. Although pathways involved are becoming better understood, outstanding issues …

  Authors: Yuki Sugiyama, Richard J W Stump, Anke Nguyen, Li Wen, Yongjuan Chen, Yanshu Wang, Jennifer N Murdoch, Frank J Lovicu, John W McAvoy

  Source: Developmental biology. 2010 Feb 15

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• PHR1, a PH domain-containing protein expressed in primary sensory neurons.

  Previously, we identified PHR1 as an abundantly expressed gene in photoreceptors and showed that it encodes four isoforms, each with N-terminal plecks…

  Authors: Shunbin Xu, Yanshu Wang, Haiqing Zhao, Lilei Zhang, Weihong Xiong, King-Wai Yau, Hakim Hiel, Elisabeth Glowatzki, David K Ryugo, David Valle

  Source: Molecular and cellular biology. 2004 Oct

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• Tissue/planar cell polarity in vertebrates: new insights and new questions.

  This review focuses on the tissue/planar cell polarity (PCP) pathway and its role in generating spatial patterns in vertebrates. Current evidence sugg…

  Authors: Yanshu Wang, Jeremy Nathans

  Source: Development (Cambridge, England). 2007 Feb

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• Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling.

  Previous work has identified axonal outgrowth and/or guidance defects in the brain and spinal cord of prenatal Frizzled3 (Fz3)(-/-) mice. To systemati…

  Authors: Yanshu Wang, Jiangyang Zhang, Susumu Mori, Jeremy Nathans

  Source: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Jan 11

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• An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus.

  Frizzled5 (Fz5), a putative Wnt receptor, is expressed in the retina, hypothalamus, and the parafascicular nucleus (PFN) of the thalamus. By construct…

  Authors: Chunqiao Liu, Yanshu Wang, Philip M Smallwood, Jeremy Nathans

  Source: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 May 28

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• Order from disorder: Self-organization in mammalian hair patterning.

  Hairs, feathers, and scales normally exhibit precise orientations with respect to the body axes. In Frizzled6 (Fz6)(-/-) mice, the global orientation …

  Authors: Yanshu Wang, Tudor Badea, Jeremy Nathans

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Dec 26

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• The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.

  In the mouse, Frizzled3 (Fz3) and Frizzled6 (Fz6) have been shown previously to control axonal growth and guidance in the CNS and hair patterning in t…

  Authors: Yanshu Wang, Nini Guo, Jeremy Nathans

  Source: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Feb 22

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