1 to 10 of 1,075 literature results

• A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.

  We report heterozygous mutations in the genes encoding either type I or type II transforming growth factor beta receptor in ten families with a newly …

  Authors: Bart L Loeys, Junji Chen, Enid R Neptune, Daniel P Judge, Megan Podowski, Tammy Holm, Jennifer Meyers, Carmen C Leitch, Nicholas Katsanis, Neda Sharifi,…

  Source: Nature genetics. 2005 Mar

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• Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE.

  PURPOSE: 4-Hydroxy-2-nonenal (4-HNE) is a major lipid peroxidation product in the retina and the retinal pigment epithelium. The purpose of the presen…

  Authors: Jianbin Chen, Ling Wang, Yan Chen, Paul Sternberg, Jiyang Cai

  Source: Investigative ophthalmology & visual science. 2009 Feb

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• Nanoparticle-mediated IgE-receptor aggregation and signaling in RBL mast cells.

  Complex cell behaviors are usually triggered by multivalent ligands that first bind to membrane receptors and then promote receptor clustering, thus a…

  Authors: Yu-Fen Huang, Haipeng Liu, Xiangling Xiong, Yan Chen, Weihong Tan

  Source: Journal of the American Chemical Society. 2009 Dec 2

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• Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice.

  BACKGROUND & AIMS: The enteric nervous system (ENS) controls intestinal peristalsis, and defective development of this system results in hypo/aganglio…

  Authors: Vincent C H Lui, William W C Cheng, Thomas Y Y Leon, Danny K C Lau, Maria-Mercedes Garcia-Barcelo, Maria-Mercedes Garcia-Bareclo, Xiao P Miao, Mandy K M Kam, Man T So, Yan Chen,…

  Source: Gastroenterology. 2008 Apr

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• Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.

  The intracellular signaling mechanisms underlying the pathogenesis of cardiac diseases are not fully understood. We report here that selective deletio…

  Authors: Frederic Princen, Emilie Bard, Farah Sheikh, Sharon S Zhang, Jing Wang, Wagner M Zago, Dongmei Wu, Ramon Diaz Trelles, Beatrice Bailly-Maitre, C Ronald Kahn,…

  Source: Molecular and cellular biology. 2009 Jan

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• Intragenic deletion of Tgif causes defectsin brain development.

  TG-interacting factor (TGIF) is a homeodomain-containing protein and functions as a transcriptional repressor within the TGF-beta and retinoic acid si…

  Authors: Chenzhong Kuang, Yan Xiao, Ling Yang, Qian Chen, Zhenzhen Wang, Simon J Conway, Yan Chen

  Source: Human molecular genetics. 2006 Dec 15

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• Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatus.

  Upon ligand binding, G-protein-coupled receptors (GPCRs) impart the signal to heterotrimeric G proteins composed of alpha, beta, and gamma subunits, l…

  Authors: Yuhui Jiang, Xiaoduo Xie, Yixuan Zhang, Xiaolin Luo, Xiao Wang, Fengjuan Fan, Dawei Zheng, Zhenzhen Wang, Yan Chen

  Source: Molecular and cellular biology. 2010 Jan

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• Nicotine promotes mammary tumor migration via a signaling cascade involving protein kinase C and CDC42.

  Nicotine, one of the major components in tobacco, is at high concentrations in the bloodstream of cigarette smokers. However, the mechanisms of how ni…

  Authors: Jinjin Guo, Soichiro Ibaragi, Tongbo Zhu, Ling-Yu Luo, Guo-Fu Hu, Petra S Huppi, Chang Yan Chen

  Source: Cancer research. 2008 Oct 15

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• Fluorescence fluctuation spectroscopy of mCherry in living cells.

  The red fluorescent protein mCherry is of considerable interest for fluorescence fluctuation spectroscopy (FFS), because the wide separation in color …

  Authors: Bin Wu, Yan Chen, Joachim D Müller

  Source: Biophysical journal. 2009 Mar 18

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• Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies.

  Given that erythropoietin (EPO) is no longer believed to have exclusive biological activity in the hematopoietic system, EPO is now considered to have…

  Authors: Kenneth Maiese, Zhao Zhong Chong, Faqi Li, Yan Chen Shang

  Source: Progress in neurobiology. 2008 Jun

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