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1 to 10 of 21 literature results
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Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808.
The sympathetic nervous system is a critical regulator of cardiac function (heart rate and contractility) in health and disease. Sympathetic nervous s…
Authors: Scott M MacDonnell, Gerardo García-Rivas, Joseph A Scherman, Hajime Kubo, Xiongwen Chen, Héctor Valdivia, Steven R Houser
Source: Circulation research. 2008 Apr 25
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Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Protein kinase (PK)Calpha, PKCbeta, and PKCgamma comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac disease respons…
Authors: Qinghang Liu, Xiongwen Chen, Scott M Macdonnell, Evangelia G Kranias, John N Lorenz, Michael Leitges, Steven R Houser, Jeffery D Molkentin
Source: Circulation research. 2009 Jul 17
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CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes.
RATIONALE: Pathological cardiac myocyte hypertrophy is thought to be induced by the persistent increases in intracellular Ca(2+) needed to maintain ca…
Authors: Scott M MacDonnell, Jutta Weisser-Thomas, Hajime Kubo, Marie Hanscome, Qinghang Liu, Naser Jaleel, Remus Berretta, Xiongwen Chen, Joan H Brown, Abdel-Karim Sabri,…
Source: Circulation research. 2009 Aug 14
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Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes.
T-type Ca(2+) channels (TTCCs) are expressed in the developing heart, are not present in the adult ventricle, and are reexpressed in cardiac diseases …
Authors: Naser Jaleel, Hiroyuki Nakayama, Xiongwen Chen, Hajime Kubo, Scott MacDonnell, Hongyu Zhang, Remus Berretta, Jeffrey Robbins, Leanne Cribbs, Jeffery D Molkentin,…
Source: Circulation research. 2008 Nov 7
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G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.
Myocardial G protein-coupled receptor kinase (GRK)2 is a critical regulator of cardiac beta-adrenergic receptor (betaAR) signaling and cardiac functio…
Authors: Philip W Raake, Leif E Vinge, Erhe Gao, Matthieu Boucher, Giuseppe Rengo, Xiongwen Chen, Brent R DeGeorge, Scot Matkovich, Steven R Houser, Patrick Most,…
Source: Circulation research. 2008 Aug 15
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Evidence for K+-dependent HCO3- utilization in the marine diatom Phaeodactylum tricornutum.
Photosynthetic utilization of inorganic carbon in the marine diatom Phaeodactylum tricornutum was investigated by the pH drift experiment, measurement…
Authors: Xiongwen Chen, C E Qiu, J Z Shao
Source: Plant physiology. 2006 Jun
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Alterations in early action potential repolarization causes localized failure of sarcoplasmic reticulum Ca2+ release.
Depressed contractility of failing myocytes involves a decreased rate of rise of the Ca2+ transient. Synchronization of Ca2+ release from the junction…
Authors: David M Harris, Geoffrey D Mills, Xiongwen Chen, Hajime Kubo, Remus M Berretta, V Scott Votaw, Luis F Santana, Steven R Houser
Source: Circulation research. 2005 Mar 18
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Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.
BACKGROUND: Both the A1- and A3-adenosine receptors (ARs) have been implicated in mediating the cardioprotective effects of adenosine. Paradoxically, …
Authors: Hajime Funakoshi, Tung O Chan, Julie C Good, Joseph R Libonati, Jarkko Piuhola, Xiongwen Chen, Scott M MacDonnell, Ling L Lee, David E Herrmann, Jin Zhang,…
Source: Circulation. 2006 Nov 21
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Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties.
Recent studies suggest that rather than being terminally differentiated, the adult heart is a self-renewing organ with the capacity to generate new my…
Authors: Xiongwen Chen, Rachel M Wilson, Hajime Kubo, Remus M Berretta, David M Harris, Xiaoying Zhang, Naser Jaleel, Scott M MacDonnell, Claudia Bearzi, Jochen Tillmanns,…
Source: Circulation research. 2007 Mar 2
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Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes.
Increases in Ca2+ influx through the L-type Ca2+ channel (LTCC, Cav1.2) augment sarcoplasmic reticulum (SR) Ca2+ loading and the amplitude of the cyto…
Authors: Xiongwen Chen, Xiaoying Zhang, Hajime Kubo, David M Harris, Geoffrey D Mills, Jed Moyer, Remus Berretta, Sabine Telemaque Potts, James D Marsh, Steven R Houser
Source: Circulation research. 2005 Nov 11
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