10 literature results

• Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18.

  Parkinson disease (PD) is a complex, multifactorial neurodegenerative disease with substantial evidence for genetic risk factors. We conducted a genom…

  Authors: Xiaoyi Gao, Eden R Martin, Yutao Liu, Gregory Mayhew, Jeffery M Vance, William K Scott

  Source: American journal of human genetics. 2009 Apr

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• Using allele sharing distance for detecting human population stratification.

  There is a long history of using allele sharing distance (ASD) and closely related metrics for population stratification analysis. However, the theory…

  Authors: Xiaoyi Gao, Eden R Martin

  Source: Human heredity. 2009

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• A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms.

  Multiple testing is a challenging issue in genetic association studies using large numbers of single nucleotide polymorphism (SNP) markers, many of wh…

  Authors: Xiaoyi Gao, Joshua Starmer, Eden R Martin

  Source: Genetic epidemiology. 2008 May

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• Avoiding the high Bonferroni penalty in genome-wide association studies.

  A major challenge in genome-wide association studies (GWASs) is to derive the multiple testing threshold when hypothesis tests are conducted using a l…

  Authors: Xiaoyi Gao, Lewis C Becker, Diane M Becker, Joshua D Starmer, Michael A Province

  Source: Genetic epidemiology. 2010 Jan

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• AWclust: point-and-click software for non-parametric population structure analysis.

  BACKGROUND: Population structure analysis is important to genetic association studies and evolutionary investigations. Parametric approaches, e.g. STR…

  Authors: Xiaoyi Gao, Joshua D Starmer

  Source: BMC bioinformatics. 2008

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• Human population structure detection via multilocus genotype clustering.

  BACKGROUND: We describe a hierarchical clustering algorithm for using Single Nucleotide Polymorphism (SNP) genetic data to assign individuals to popul…

  Authors: Xiaoyi Gao, Joshua Starmer

  Source: BMC genetics. 2007

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• Longitudinal trends in the association of metabolic syndrome with 550 k single-nucleotide polymorphisms in the Framingham Heart Study.

  ABSTRACT : We investigated the association of metabolic syndrome (MetS) with a 500 k and a 50 k single-nucleotide polymorphism (SNP) gene chip in the …

  Authors: Yong-Moon Park, Michael A Province, Xiaoyi Gao, Mary Feitosa, Jun Wu, Duanduan Ma, Dc Rao, Aldi T Kraja

  Source: BMC proceedings. 2009

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• Disease associations and family-based tests.

  This unit describes the statistical techniques necessary for performing family-based association studies (such as the TDT) for genetic polymorphisms. …

  Authors: Warren J Ewens, Richard S Spielman, Norman L Kaplan, Xiaoyi Gao, Richard W Morris, Eden R Martin

  Source: Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]. 2008 Jul

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• A framework for analyzing both linkage and association: an analysis of Genetic Analysis Workshop 16 simulated data.

  ABSTRACT : We examine a Bayesian Markov-chain Monte Carlo framework for simultaneous segregation and linkage analysis in the simulated single-nucleoti…

  Authors: E Warwick Daw, Jevon Plunkett, Mary Feitosa, Xiaoyi Gao, Andrew Van Brunt, Duanduan Ma, Jacek Czajkowski, Michael A Province, Ingrid Borecki

  Source: BMC proceedings. 2009

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• NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.

  Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, …

  Authors: Nancy L Heard-Costa, M Carola Zillikens, Keri L Monda, Asa Johansson, Tamara B Harris, Mao Fu, Talin Haritunians, Mary F Feitosa, Thor Aspelund, Gudny Eiriksdottir,…

  Source: PLoS genetics. 2009 Jun

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