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Diversity-based, model-guided construction of synthetic gene networks with predicted functions.
Engineering artificial gene networks from modular components is a major goal of synthetic biology. However, the construction of gene networks with pre…
Authors: Tom Ellis, Xiao Wang, James J Collins
Source: Nature biotechnology. 2009 May
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Gene regulation: hacking the network on a sugar high.
In a recent issue of Molecular Cell, Kaplan et al. (2008) determine the input functions for 19 E. coli sugar-utilization genes by using a two-dimensio…
Authors: Tom Ellis, Xiao Wang, James J Collins
Source: Molecular cell. 2008 Apr 11
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A bottom-up approach to gene regulation.
The ability to construct synthetic gene networks enables experimental investigations of deliberately simplified systems that can be compared to qualit…
Authors: Nicholas J Guido, Xiao Wang, David Adalsteinsson, David McMillen, Jeff Hasty, Charles R Cantor, Timothy C Elston, J J Collins
Source: Nature. 2006 Feb 16
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Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatus.
Upon ligand binding, G-protein-coupled receptors (GPCRs) impart the signal to heterotrimeric G proteins composed of alpha, beta, and gamma subunits, l…
Authors: Yuhui Jiang, Xiaoduo Xie, Yixuan Zhang, Xiaolin Luo, Xiao Wang, Fengjuan Fan, Dawei Zheng, Zhenzhen Wang, Yan Chen
Source: Molecular and cellular biology. 2010 Jan
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Interaction of the Tobacco mosaic virus replicase protein with a NAC domain transcription factor is associated with the suppression of systemic host defenses.
An interaction between the helicase domain of the Tobacco mosaic virus (TMV) 126-/183-kDa replicase protein(s) and the Arabidopsis thaliana NAC domain…
Authors: Xiao Wang, Sameer P Goregaoker, James N Culver
Source: Journal of virology. 2009 Oct
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Foldamer organogels: a circular dichroism study of glucose-mediated dynamic helicity induction and amplification.
This paper reports a systematic study of the dynamic process for the self-assembly of chiral organogels from achiral hydrogen bonded hydrazide foldame…
Authors: Wei Cai, Gui-Tao Wang, Ping Du, Ren-Xiao Wang, Xi-Kui Jiang, Zhan-Ting Li
Source: Journal of the American Chemical Society. 2008 Oct 8
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Toll-like receptor 2-mediated peptidoglycan uptake by immature intestinal epithelial cells from apical side and exosome-associated transcellular transcytosis.
Peptidoglycan (PGN) is a potent immune adjuvant derived from bacterial cell walls. Previous investigations suggest that intestinal epithelium may abso…
Authors: Heng-Fu Bu, Xiao Wang, Yi Tang, Viola Koti, Xiao-Di Tan
Source: Journal of cellular physiology. 2010 Mar
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RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells.
Raf kinase trapping to Golgi (RKTG) is a newly characterized negative regulator of the Ras-Raf-mitogen-activated and extracellular signal-regulated ki…
Authors: Fengjuan Fan, Lin Feng, Jing He, Xiao Wang, Xiaomeng Jiang, Yixuan Zhang, Zhenzhen Wang, Yan Chen
Source: Carcinogenesis. 2008 Jun
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GEPS: the Gene Expression Pattern Scanner.
Gene Expression Pattern Scanner (GEPS) is a web-based server to provide interactive pattern analysis of user-submitted microarray data for facilitatin…
Authors: Yu-Peng Wang, Liang Liang, Bu-Cong Han, Yu Quan, Xiao Wang, Tao Tao, Zhi-Liang Ji
Source: Nucleic acids research. 2006 Jul 1
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Diastereo- and enantioselective Aza-MBH-type reaction of nitroalkenes to N-tosylimines catalyzed by bifunctional organocatalysts.
The first example of diastereo- and enantioselective aza-MBH-type reaction was accomplished by the asymmetric synthesis of beta-nitro-gamma-enamines v…
Authors: Xiao Wang, Yong-Fei Chen, Liang-Feng Niu, Peng-Fei Xu
Source: Organic letters. 2009 Aug 6
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