1 to 10 of 17 literature results

• Tumor self-seeding by circulating cancer cells.

  Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is thought that this is a unidirectional process. Here we show…

  Authors: Mi-Young Kim, Thordur Oskarsson, Swarnali Acharyya, Don X Nguyen, Xiang H-F Zhang, Larry Norton, Joan Massagué

  Source: Cell. 2009 Dec 24

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• WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.

  Metastasis from lung adenocarcinoma can occur swiftly to multiple organs within months of diagnosis. The mechanisms that confer this rapid metastatic …

  Authors: Don X Nguyen, Anne C Chiang, Xiang H-F Zhang, Juliet Y Kim, Mark G Kris, Marc Ladanyi, William L Gerald, Joan Massagué

  Source: Cell. 2009 Jul 10

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• Genes that mediate breast cancer metastasis to the brain.

  The molecular basis for breast cancer metastasis to the brain is largely unknown. Brain relapse typically occurs years after the removal of a breast t…

  Authors: Paula D Bos, Xiang H-F Zhang, Cristina Nadal, Weiping Shu, Roger R Gomis, Don X Nguyen, Andy J Minn, Marc J van de Vijver, William L Gerald, John A Foekens,…

  Source: Nature. 2009 Jun 18

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• TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.

  Cells released from primary tumors seed metastases to specific organs by a nonrandom process, implying the involvement of biologically selective mecha…

  Authors: David Padua, Xiang H-F Zhang, Qiongqing Wang, Cristina Nadal, William L Gerald, Roger R Gomis, Joan Massagué

  Source: Cell. 2008 Apr 4

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• Latent bone metastasis in breast cancer tied to Src-dependent survival signals.

  Metastasis may arise years after removal of a primary tumor. The mechanisms allowing latent disseminated cancer cells to survive are unknown. We repor…

  Authors: Xiang H-F Zhang, Qiongqing Wang, William Gerald, Clifford A Hudis, Larry Norton, Marcel Smid, John A Foekens, Joan Massagué

  Source: Cancer cell. 2009 Jul 7

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• Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition.

  Alternative splicing makes a major contribution to proteomic diversity in higher eukaryotes with approximately 70% of genes encoding two or more isofo…

  Authors: Yang Yu, Patricia A Maroney, John A Denker, Xiang H-F Zhang, Olexandr Dybkov, Reinhard Lührmann, Eckhard Jankowsky, Lawrence A Chasin, Timothy W Nilsen

  Source: Cell. 2008 Dec 26

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• Positive selection acting on splicing motifs reflects compensatory evolution.

  We have used comparative genomics to characterize the evolutionary behavior of predicted splicing regulatory motifs. Using base substitution rates in …

  Authors: Shengdong Ke, Xiang H-F Zhang, Lawrence A Chasin

  Source: Genome research. 2008 Apr

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• Computational definition of sequence motifs governing constitutive exon splicing.

  We have searched for sequence motifs that contribute to the recognition of human pre-mRNA splice sites by comparing the frequency of 8-mers in interna…

  Authors: Xiang H-F Zhang, Lawrence A Chasin

  Source: Genes & development. 2004 Jun 1

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• Exon inclusion is dependent on predictable exonic splicing enhancers.

  We have previously formulated a list of approximately 2,000 RNA octamers as putative exonic splicing enhancers (PESEs) based on a statistical comparis…

  Authors: Xiang H-F Zhang, Thaned Kangsamaksin, Mann S P Chao, Joydeep K Banerjee, Lawrence A Chasin

  Source: Molecular and cellular biology. 2005 Aug

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• Dichotomous splicing signals in exon flanks.

  Intronic elements flanking the splice-site consensus sequences are thought to play a role in pre-mRNA splicing. However, the generality of this role, …

  Authors: Xiang H-F Zhang, Christina S Leslie, Lawrence A Chasin

  Source: Genome research. 2005 Jun

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