1 to 7 of 7 literature results

• Structure-reactivity effects on primary deuterium isotope effects on protonation of ring-substituted alpha-methoxystyrenes.

  Primary product isotope effects (PIEs) on L(+) and carboxylic acid catalyzed protonation of ring-substituted alpha-methoxystyrenes (X-1) to form oxoca…

  Authors: Wing-Yin Tsang, John P Richard

  Source: Journal of the American Chemical Society. 2009 Oct 7

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• Dinuclear Zn(II) complex promotes cleavage and isomerization of 2-hydroxypropyl alkyl phosphates by a common cyclic phosphate intermediate.

  The kinetics and cleavage products of 2-hydroxypropyl p-nitrophenyl phosphate were determined in methanol containing the di-Zn(II) complex of bis-1,3-…

  Authors: Wing Yin Tsang, David R Edwards, Stephanie A Melnychuk, C Tony Liu, Chaomin Liu, Alexei A Neverov, Nicholas H Williams, R Stan Brown

  Source: Journal of the American Chemical Society. 2009 Mar 25

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• A substrate in pieces: allosteric activation of glycerol 3-phosphate dehydrogenase (NAD+) by phosphite dianion.

  The ratio of the second-order rate constants for reduction of dihydroxyacetone phosphate (DHAP) and of the neutral truncated substrate glycolaldehyde …

  Authors: Wing-Yin Tsang, Tina L Amyes, John P Richard

  Source: Biochemistry. 2008 Apr 22

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• Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors.

  A new class of inhibitors 4-oxo-beta-lactams (azetidine-2,4-diones), containing the required structural elements for molecular recognition, inhibit po…

  Authors: Jalmira Mulchande, Rita C Guedes, Wing-Yin Tsang, Michael I Page, Rui Moreira, Jim Iley

  Source: Journal of medicinal chemistry. 2008 Mar 27

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• A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier.

  Authors: Wing-Yin Tsang, John P Richard

  Source: Journal of the American Chemical Society. 2007 Aug 29

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• On the question of stepwise vs. concerted cleavage of RNA models promoted by a synthetic dinuclear Zn(II) complex in methanol: implementation of a noncleavable phosphonate probe.

  To address the question of concerted versus a stepwise reaction mechanisms for the cyclization of the 2-hydroxypropyl aryl and alkyl RNA models (1a-k)…

  Authors: David R Edwards, Wing-Yin Tsang, Alexei A Neverov, R Stan Brown

  Source: Organic & biomolecular chemistry. 2010 Feb 21

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• Reactivity and selectivity in the inhibition of elastase by 3-oxo-beta-sultams and in their hydrolysis.

  3-oxo-beta-sultams are both beta-sultams and beta-lactams and are a novel class of time-dependent inhibitors of elastase. The inhibition involves form…

  Authors: Wing-Yin Tsang, Naveed Ahmed, Karl Hemming, Michael I Page

  Source: Organic & biomolecular chemistry. 2007 Dec 21

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