1 to 7 of 7 literature results

• Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.

  Interferons (IFNs) direct innate and acquired immune responses and, accordingly, are used therapeutically to treat a number of diseases, yet the diver…

  Authors: Dakang Xu, Michelle Holko, Anthony J Sadler, Bernadette Scott, Shigeki Higashiyama, Windy Berkofsky-Fessler, Melanie J McConnell, Pier Paolo Pandolfi, Jonathan D Licht, Bryan R G Williams

  Source: Immunity. 2009 Jun 19

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• Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.

  Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activ…

  Authors: Leopoldo Luistro, Wei He, Melissa Smith, Kathryn Packman, Maria Vilenchik, Daisy Carvajal, John Roberts, James Cai, Windy Berkofsky-Fessler, Holly Hilton,…

  Source: Cancer research. 2009 Oct 1

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• Preclinical biomarkers for a cyclin-dependent kinase inhibitor translate to candidate pharmacodynamic biomarkers in phase I patients.

  A genomics-based approach to identify pharmacodynamic biomarkers was used for a cyclin-dependent kinase inhibitory drug. R547 is a potent cyclin-depen…

  Authors: Windy Berkofsky-Fessler, Tri Q Nguyen, Paul Delmar, Juliette Molnos, Charu Kanwal, Wanda DePinto, James Rosinski, Patricia McLoughlin, Steve Ritland, Mark DeMario,…

  Source: Molecular cancer therapeutics. 2009 Sep

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• Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression.

  The transcriptional repressor PLZF was identified by its translocation with retinoic acid receptor alpha in t(11;17) acute promyelocytic leukemia (APL…

  Authors: Melanie J McConnell, Nathalie Chevallier, Windy Berkofsky-Fessler, Jena M Giltnane, Rupal B Malani, Louis M Staudt, Jonathan D Licht

  Source: Molecular and cellular biology. 2003 Dec

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• WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression.

  In its role as a tumor suppressor, WT1 transactivates several genes that are regulators of cell growth and differentiation pathways. For instance, WT1…

  Authors: Debra J Morrison, Marianne K H Kim, Windy Berkofsky-Fessler, Jonathan D Licht

  Source: Molecular cancer research : MCR. 2008 Jul

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• Identification of a neocentromere in a rearranged Y chromosome with no detectable DYZ3 centromeric sequence.

  An 18-year-old woman was evaluated because of primary amenorrhea and hypogonadism. Chromosome analysis from peripheral blood lymphocytes revealed a no…

  Authors: Juliana Godoy Assumpção, Windy Berkofsky-Fessler, Nilma Viguetti Campos, Andréa Trevas Maciel-Guerra, Shulan Li, Maria Isabel Melaragno, Maricilda Palandi de Mello, Peter E Warburton

  Source: American journal of medical genetics. 2002 Dec 1

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• A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.

  The Wilms tumor gene (WT1) is mutated or deleted in patients with heredofamilial syndromes associated with the development of Wilms tumors, but is inf…

  Authors: Marianne K-H Kim, Jacqueline M Mason, Chi-Ming Li, Windy Berkofsky-Fessler, Le Jiang, Divaker Choubey, Paul E Grundy, Benjamin Tycko, Jonathan D Licht

  Source: Neoplasia (New York, N.Y.). 2008 Jan

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