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The first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation …
Authors: Brett S Carver, Jennifer Tran, Zhenbang Chen, Arkaitz Carracedo-Perez, Andrea Alimonti, Caterina Nardella, Anuradha Gopalan, Peter T Scardino, Carlos Cordon-Cardo, William Gerald,…
Source: Nature. 2009 Feb 12
View Full TextMetastasis may arise years after removal of a primary tumor. The mechanisms allowing latent disseminated cancer cells to survive are unknown. We repor…
Authors: Xiang H-F Zhang, Qiongqing Wang, William Gerald, Clifford A Hudis, Larry Norton, Marcel Smid, John A Foekens, Joan Massagué
Source: Cancer cell. 2009 Jul 7
View Full TextChromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant…
Authors: Brett S Carver, Jennifer Tran, Anuradha Gopalan, Zhenbang Chen, Safa Shaikh, Arkaitz Carracedo, Andrea Alimonti, Caterina Nardella, Shohreh Varmeh, Peter T Scardino,…
Source: Nature genetics. 2009 May
View Full TextThe mammalian target of rapamycin (mTOR) represents a critical signaling crossroad where pathways commonly disrupted in cancer converge. We report her…
Authors: Caterina Nardella, Zhenbang Chen, Leonardo Salmena, Arkaitz Carracedo, Andrea Alimonti, Ainara Egia, Brett Carver, William Gerald, Carlos Cordon-Cardo, Pier Paolo Pandolfi
Source: Genes & development. 2008 Aug 15
View Free Full TextCellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro, but the relevance o…
Authors: Zhenbang Chen, Lloyd C Trotman, David Shaffer, Hui-Kuan Lin, Zohar A Dotan, Masaru Niki, Jason A Koutcher, Howard I Scher, Thomas Ludwig, William Gerald,…
Source: Nature. 2005 Aug 4
View Free Full TextAdvanced human cancers are invariably aneuploid, in that they harbour cells with abnormal chromosome numbers. However, the molecular defects underlyin…
Authors: Eva Hernando, Zaher Nahlé, Gloria Juan, Elena Diaz-Rodriguez, Miguel Alaminos, Michael Hemann, Loren Michel, Vivek Mittal, William Gerald, Robert Benezra,…
Source: Nature. 2004 Aug 12
View Full TextThe persistent activation of signal transducer and activator of transcription 3 (Stat3) is a common feature of prostate cancer. However, little is kno…
Authors: Janeen Azare, Kenneth Leslie, Hikmat Al-Ahmadie, William Gerald, Paul H Weinreb, Shelia M Violette, Jacqueline Bromberg
Source: Molecular and cellular biology. 2007 Jun
View Free Full TextFactors that drive prostate cancer progression remain poorly defined, thus hindering the development of new therapeutic strategies. Disseminated tumor…
Authors: Hui Shen, Nathan Powers, Nitin Saini, Clay E S Comstock, Ankur Sharma, Katherine Weaver, Monica P Revelo, William Gerald, Erin Williams, Walter J Jessen,…
Source: Cancer research. 2008 Dec 15
View Full TextAngiogenic defects in Id mutant mice inhibit the growth of tumor xenografts, providing a genetic model for antiangiogenic stress. Our work tests the c…
Authors: Marianna B Ruzinova, Rebecca A Schoer, William Gerald, James E Egan, Pier Paolo Pandolfi, Shahin Rafii, Katia Manova, Vivek Mittal, Robert Benezra
Source: Cancer cell. 2003 Oct
View Full TextThe categorization of prostate cancers that are progressing after castration as 'hormone-refractory' evolved from the clinical observation that surgic…
Authors: Howard I Scher, Grant Buchanan, William Gerald, Lisa M Butler, Wayne D Tilley
Source: Endocrine-related cancer. 2004 Sep
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