1 to 10 of 47 literature results

• ETS rearrangements and prostate cancer initiation.

  The first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation …

  Authors: Brett S Carver, Jennifer Tran, Zhenbang Chen, Arkaitz Carracedo-Perez, Andrea Alimonti, Caterina Nardella, Anuradha Gopalan, Peter T Scardino, Carlos Cordon-Cardo, William Gerald,…

  Source: Nature. 2009 Feb 12

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• Latent bone metastasis in breast cancer tied to Src-dependent survival signals.

  Metastasis may arise years after removal of a primary tumor. The mechanisms allowing latent disseminated cancer cells to survive are unknown. We repor…

  Authors: Xiang H-F Zhang, Qiongqing Wang, William Gerald, Clifford A Hudis, Larry Norton, Marcel Smid, John A Foekens, Joan Massagué

  Source: Cancer cell. 2009 Jul 7

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• Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.

  Chromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant…

  Authors: Brett S Carver, Jennifer Tran, Anuradha Gopalan, Zhenbang Chen, Safa Shaikh, Arkaitz Carracedo, Andrea Alimonti, Caterina Nardella, Shohreh Varmeh, Peter T Scardino,…

  Source: Nature genetics. 2009 May

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• Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.

  The mammalian target of rapamycin (mTOR) represents a critical signaling crossroad where pathways commonly disrupted in cancer converge. We report her…

  Authors: Caterina Nardella, Zhenbang Chen, Leonardo Salmena, Arkaitz Carracedo, Andrea Alimonti, Ainara Egia, Brett Carver, William Gerald, Carlos Cordon-Cardo, Pier Paolo Pandolfi

  Source: Genes & development. 2008 Aug 15

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• Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.

  Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro, but the relevance o…

  Authors: Zhenbang Chen, Lloyd C Trotman, David Shaffer, Hui-Kuan Lin, Zohar A Dotan, Masaru Niki, Jason A Koutcher, Howard I Scher, Thomas Ludwig, William Gerald,…

  Source: Nature. 2005 Aug 4

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• Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

  Advanced human cancers are invariably aneuploid, in that they harbour cells with abnormal chromosome numbers. However, the molecular defects underlyin…

  Authors: Eva Hernando, Zaher Nahlé, Gloria Juan, Elena Diaz-Rodriguez, Miguel Alaminos, Michael Hemann, Loren Michel, Vivek Mittal, William Gerald, Robert Benezra,…

  Source: Nature. 2004 Aug 12

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• Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6.

  The persistent activation of signal transducer and activator of transcription 3 (Stat3) is a common feature of prostate cancer. However, little is kno…

  Authors: Janeen Azare, Kenneth Leslie, Hikmat Al-Ahmadie, William Gerald, Paul H Weinreb, Shelia M Violette, Jacqueline Bromberg

  Source: Molecular and cellular biology. 2007 Jun

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• The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer.

  Factors that drive prostate cancer progression remain poorly defined, thus hindering the development of new therapeutic strategies. Disseminated tumor…

  Authors: Hui Shen, Nathan Powers, Nitin Saini, Clay E S Comstock, Ankur Sharma, Katherine Weaver, Monica P Revelo, William Gerald, Erin Williams, Walter J Jessen,…

  Source: Cancer research. 2008 Dec 15

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• Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors.

  Angiogenic defects in Id mutant mice inhibit the growth of tumor xenografts, providing a genetic model for antiangiogenic stress. Our work tests the c…

  Authors: Marianna B Ruzinova, Rebecca A Schoer, William Gerald, James E Egan, Pier Paolo Pandolfi, Shahin Rafii, Katia Manova, Vivek Mittal, Robert Benezra

  Source: Cancer cell. 2003 Oct

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• Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer.

  The categorization of prostate cancers that are progressing after castration as 'hormone-refractory' evolved from the clinical observation that surgic…

  Authors: Howard I Scher, Grant Buchanan, William Gerald, Lisa M Butler, Wayne D Tilley

  Source: Endocrine-related cancer. 2004 Sep

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