1 to 10 of 67 literature results

• Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone.

  BACKGROUND: The restrictive filling pattern seen with severe heart failure (HF) may be due to diastolic dysfunction with elevated left ventricular (LV…

  Authors: Satoshi Masutani, William C Little, Hiroshi Hasegawa, Heng-Jie Cheng, Che-Ping Cheng

  Source: Circulation. 2008 Mar 25

  View Full Text

• Stretched extracellular matrix proteins turn fouling and are functionally rescued by the chaperones albumin and casein.

  While evidence is mounting that cells exploit protein unfolding for mechanochemical signal conversion (mechanotransduction), what mechanisms are in pl…

  Authors: William C Little, Ruth Schwartlander, Michael L Smith, Delphine Gourdon, Viola Vogel

  Source: Nano letters. 2009 Dec

  View Full Text

• Hypertension, heart failure, and ejection fraction.

  Authors: William C Little

  Source: Circulation. 2008 Nov 25

  View Full Text

• Statin therapy may be associated with lower mortality in patients with diastolic heart failure: a preliminary report.

  BACKGROUND: No therapy has been shown to improve survival in heart failure (HF) with a normal ejection fraction (EF). There are plausible reasons to h…

  Authors: Hidekatsu Fukuta, David C Sane, Steffen Brucks, William C Little

  Source: Circulation. 2005 Jul 19

  View Full Text

• Echocardiographic evaluation of diastolic function can be used to guide clinical care.

  Authors: William C Little, Jae K Oh

  Source: Circulation. 2009 Sep 1

  View Full Text

• Off-label" stent therapy 2-year comparison of drug-eluting versus bare-metal stents.

  OBJECTIVE: The aim was to compare 2-year outcomes with the routine use of drug-eluting stents (DES) (>75% "off-label") with a comparable group treated…

  Authors: Robert J Applegate, Matthew T Sacrinty, Michael A Kutcher, Renato M Santos, Sanjay K Gandhi, Talal T Baki, William C Little

  Source: Journal of the American College of Cardiology. 2008 Feb 12

  View Full Text

• Acute heart failure with preserved systolic function.

  Many patients with acute heart failure have marked hypertension and preserved left ventricular ejection fraction. In these patients, the heart failure…

  Authors: Rahul Kumar, Sanjay K Gandhi, William C Little

  Source: Critical care medicine. 2008 Jan

  View Full Text

• Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy.

  BACKGROUND: Activation of the renin-angiotensin system (RAS) may contribute to the development of alcoholic cardiomyopathy. We evaluated the effect of…

  Authors: Che-Ping Cheng, Heng-Jie Cheng, Carol Cunningham, Zakariya K Shihabi, David C Sane, Thomas Wannenburg, William C Little

  Source: Circulation. 2006 Jul 18

  View Full Text

• Diastolic heart failure can be diagnosed by comprehensive two-dimensional and Doppler echocardiography.

  There are many myocardial and non-myocardial conditions that cause heart failure with normal left ventricular ejection fraction (LVEF). Among them, di…

  Authors: Jae K Oh, Liv Hatle, A Jamil Tajik, William C Little

  Source: Journal of the American College of Cardiology. 2006 Feb 7

  View Full Text

• Moving beyond angiotensin II to also target aldosterone?

  Authors: William C Little, Paul M Kirkman

  Source: Journal of the American College of Cardiology. 2009 Aug 4

  View Full Text