1 to 8 of 8 literature results

• Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum.

  Industrial penicillin production with the filamentous fungus Penicillium chrysogenum is based on an unprecedented effort in microbial strain improveme…

  Authors: Marco A van den Berg, Richard Albang, Kaj Albermann, Jonathan H Badger, Jean-Marc Daran, Arnold J M Driessen, Carlos Garcia-Estrada, Natalie D Fedorova, Diana M Harris, Wilbert H M Heijne,…

  Source: Nature biotechnology. 2008 Oct

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• Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats.

  To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (…

  Authors: C Frieke Kuper, Wilbert H M Heijne, Marinus Dansen, Kitty C M Verhoeckx, Andre Boorsma, Marijana Radonjic, Joost Bruijntjes, Rob Stierum, Hans Muijser, Josje H E Arts

  Source: Toxicologic pathology. 2008

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• Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach.

  Toxicogenomics is a novel approach integrating the expression analysis of thousands of genes (transcriptomics) or proteins (proteomics) with classical…

  Authors: Wilbert H M Heijne, Rob H Stierum, Monique Slijper, Peter J van Bladeren, Ben van Ommen

  Source: Biochemical pharmacology. 2003 Mar 1

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• Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis.

  This study investigated whether integrated analysis of transcriptomics and metabolomics data increased the sensitivity of detection and provided new i…

  Authors: Wilbert H M Heijne, Robert-Jan A N Lamers, Peter J van Bladeren, John P Groten, Joop H J van Nesselrooij, Ben van Ommen

  Source: Toxicologic pathology. 2005

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• Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure.

  Benzene is an industrial chemical, component of automobile exhaust and cigarette smoke. After hepatic bioactivation benzene induces bone marrow, blood…

  Authors: Wilbert H M Heijne, Diana Jonker, Rob H Stierum, Ben van Ommen, John P Groten

  Source: Mutation research. 2005 Aug 4

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• Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology.

  Toxicogenomics can facilitate the identification and characterization of toxicity, as illustrated in this review. Toxicogenomics, the application of t…

  Authors: Wilbert H M Heijne, Anne S Kienhuis, Ben van Ommen, Rob H Stierum, John P Groten

  Source: Expert review of proteomics. 2005 Oct

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• Bromobenzene-induced hepatotoxicity at the transcriptome level.

  Rats were exposed to three levels of bromobenzene, sampled at 6, 24, and 48 h, and liver gene expression profiles were determined to identify dose and…

  Authors: Wilbert H M Heijne, Angela L Slitt, Peter J van Bladeren, John P Groten, Curtis D Klaassen, Rob H Stierum, Ben van Ommen

  Source: Toxicological sciences : an official journal of the Society of Toxicology. 2004 Jun

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• The introduction of toxicogenomics; potential new markers of hepatotoxicity.

  Authors: Wilbert H M Heijne, Rob H Stierum, Winfried R Leeman, Ben van Ommen

  Source: Cancer biomarkers : section A of Disease markers. 2005

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