1 to 10 of 41 literature results

• Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.

  Although five-year survival rates for childhood acute lymphoblastic leukemia (ALL) are now over 80% in most industrialized countries, not all children…

  Authors: Jun J Yang, Cheng Cheng, Meenakshi Devidas, Xueyuan Cao, Yiping Fan, Dario Campana, Wenjian Yang, Geoff Neale, Nancy J Cox, Paul Scheet,…

  Source: Nature genetics. 2011 Mar

  View Free Full Text

• Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.

  DNA mismatch repair enzymes (for example, MSH2) maintain genomic integrity, and their deficiency predisposes to several human cancers and to drug resi…

  Authors: Barthelemy Diouf, Qing Cheng, Natalia F Krynetskaia, Wenjian Yang, Meyling Cheok, Deqing Pei, Yiping Fan, Cheng Cheng, Evgeny Y Krynetskiy, Hui Geng,…

  Source: Nature medicine. 2011 Oct

  View Free Full Text

• Germline genomic variants associated with childhood acute lymphoblastic leukemia.

  Using the Affymetrix 500K Mapping array and publicly available genotypes, we identified 18 SNPs whose allele frequency differed significantly(P < 1 x …

  Authors: Lisa R Treviño, Wenjian Yang, Deborah French, Stephen P Hunger, William L Carroll, Meenakshi Devidas, Cheryl Willman, Geoffrey Neale, James Downing, Susana C Raimondi,…

  Source: Nature genetics. 2009 Sep

  View Free Full Text

• Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes.

  The nature of mendelian inheritance assumes that all tissues in which a phenotype of interest is expressed have a uniform diploid karyotype, which is …

  Authors: Qing Cheng, WenJian Yang, Susana C Raimondi, Ching-Hon Pui, Mary V Relling, William E Evans

  Source: Nature genetics. 2005 Aug

  View Full Text

• Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies.

  Despite an increase in survival for children with acute lymphoblastic leukemia (ALL), the outcome after relapse is poor. To understand the genetic eve…

  Authors: Laura E Hogan, Julia A Meyer, Jun Yang, Jinhua Wang, Nicholas Wong, Wenjian Yang, Gregory Condos, Stephen P Hunger, Elizabeth Raetz, Richard Saffery,…

  Source: Blood. 2011 Nov 10

  View Full Text

• The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia.

  Glucocorticoids are used in the curative treatment of acute lymphoblastic leukemia (ALL). Resistance to glucocorticoids is an important adverse progno…

  Authors: Nicolas Pottier, Wenjian Yang, Mahfoud Assem, John C Panetta, Deqing Pei, Steven W Paugh, Cheng Cheng, Monique L Den Boer, Mary V Relling, Rob Pieters,…

  Source: Journal of the National Cancer Institute. 2008 Dec 17

  View Free Full Text

• Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.

  Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in cleara…

  Authors: Laura B Ramsey, Gitte H Bruun, Wenjian Yang, Lisa R Treviño, Selina Vattathil, Paul Scheet, Cheng Cheng, Gary L Rosner, Kathleen M Giacomini, Yiping Fan,…

  Source: Genome research. 2012 Jan

  View Full Text

• Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.

  Methotrexate polyglutamates (MTXPGs) determine in vivo efficacy in acute lymphoblastic leukemia (ALL). MTXPG accumulation differs by leukemic subtypes…

  Authors: Deborah French, Wenjian Yang, Cheng Cheng, Susana C Raimondi, Charles G Mullighan, James R Downing, William E Evans, Ching-Hon Pui, Mary V Relling

  Source: Blood. 2009 May 7

  View Free Full Text

• Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.

  The underlying pathways that lead to relapse in childhood acute lymphoblastic leukemia (ALL) are unknown. To comprehensively characterize the molecula…

  Authors: Jun J Yang, Deepa Bhojwani, Wenjian Yang, Xiangjun Cai, Gabriele Stocco, Kristine Crews, Jinhua Wang, Debra Morrison, Meenakshi Devidas, Stephen P Hunger,…

  Source: Blood. 2008 Nov 15

  View Free Full Text

• Expression arrays illuminate a way forward for mantle cell lymphoma.

  Authors: William E Evans, Meyling Cheok, Wenjian Yang, Charles J Sherr

  Source: Cancer cell. 2003 Feb

  View Full Text