1 to 10 of 57 literature results

• Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

  The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of…

  Authors: Anne Barton, Wendy Thomson, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Darren Plant, Laura J Gibbons, Wellcome Trust Case Control Consortium, YEAR Consortium,…

  Source: Nature genetics. 2008 Oct

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• Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression.

  OBJECTIVE: To identify biomarkers in the first synovial fluid (SF) aspirate obtained from children with oligoarticular juvenile idiopathic arthritis (…

  Authors: Patricia J Hunter, Kiran Nistala, Nipurna Jina, Ayad Eddaoudi, Wendy Thomson, Mike Hubank, Lucy R Wedderburn

  Source: Arthritis and rheumatism. 2010 Mar

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• Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

  To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P < 0.001 in a published meta-…

  Authors: Soumya Raychaudhuri, Brian P Thomson, Elaine F Remmers, Stephen Eyre, Anne Hinks, Candace Guiducci, Joseph J Catanese, Gang Xie, Eli A Stahl, Robert Chen,…

  Source: Nature genetics. 2009 Dec

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• Rheumatoid arthritis association at 6q23.

  The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x…

  Authors: Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce,…

  Source: Nature genetics. 2007 Dec

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• Genetic variation in the hypothalamic-pituitary-adrenal stress axis influences susceptibility to musculoskeletal pain: results from the EPIFUND study.

  OBJECTIVES: /st> To determine if genetic variation in genes in the hypothalamic-pituitary-adrenal (HPA) axis, the primary stress response system, infl…

  Authors: Kate L Holliday, Barbara I Nicholl, Gary J Macfarlane, Wendy Thomson, Kelly A Davies, John McBeth

  Source: Annals of the rheumatic diseases. 2010 Mar

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• Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis.

  OBJECTIVE: To examine the role of the variants of the PTPN22 and HLA-DRB1 genes as predictors of mortality in inflammatory polyarthritis (IP) and rheu…

  Authors: Tracey M Farragher, Nicola J Goodson, Haris Naseem, Alan J Silman, Wendy Thomson, Deborah Symmons, Anne Barton

  Source: Arthritis and rheumatism. 2008 Feb

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• Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

  The concept of susceptibility genes common to different autoimmune diseases is now firmly established with previous studies demonstrating overlap of l…

  Authors: Anne Barton, Steve Eyre, Xiayi Ke, Anne Hinks, John Bowes, Edward Flynn, Paul Martin, YEAR Consortium, BIRAC Consortium, Anthony G Wilson,…

  Source: Human molecular genetics. 2009 Jul 1

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• Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis.

  OBJECTIVE: To investigate SLC26A2, the gene that causes diastrophic dysplasia, in juvenile idiopathic arthritis (JIA). METHODS: Nine polymorphisms acr…

  Authors: Rebecca Lamb, Wendy Thomson, British Society of Paediatric and Adolescent Rheumatology, Emma M Ogilvie, Rachelle Donn

  Source: Arthritis and rheumatism. 2007 Apr

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• The shared epitope hypothesis in rheumatoid arthritis: evaluation of alternative classification criteria in a large UK Caucasian cohort.

  OBJECTIVE: Many classification systems for the HLA-DRB1 allelic association with rheumatoid arthritis (RA) have been reported, but few have been valid…

  Authors: Ann W Morgan, Lubna Haroon-Rashid, Stephen G Martin, Hock-Chye Gooi, Jane Worthington, Wendy Thomson, Jennifer H Barrett, Paul Emery

  Source: Arthritis and rheumatism. 2008 May

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• Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.

  OBJECTIVE: The majority of genetic risk factors for rheumatoid arthritis (RA) are associated with anti-citrullinated protein antibody (ACPA)-positive …

  Authors: Diane van der Woude, Jeanine J Houwing-Duistermaat, René E M Toes, Tom W J Huizinga, Wendy Thomson, Jane Worthington, Annette H M van der Helm-van Mil, René R P de Vries

  Source: Arthritis and rheumatism. 2009 Apr

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