1 to 10 of 86 literature results

• Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.

  Although cancer arises from a combination of mutations in oncogenes and tumour suppressor genes, the extent to which tumour suppressor gene loss is re…

  Authors: Wen Xue, Lars Zender, Cornelius Miething, Ross A Dickins, Eva Hernando, Valery Krizhanovsky, Carlos Cordon-Cardo, Scott W Lowe

  Source: Nature. 2007 Feb 8

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• An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

  Cancers are highly heterogeneous and contain many passenger and driver mutations. To functionally identify tumor suppressor genes relevant to human ca…

  Authors: Lars Zender, Wen Xue, Johannes Zuber, Camile P Semighini, Alexander Krasnitz, Beicong Ma, Peggy Zender, Stefan Kubicka, John M Luk, Peter Schirmacher,…

  Source: Cell. 2008 Nov 28

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• ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis.

  DNA methylation is an important epigenetic mark for transcriptional gene silencing (TGS) in diverse organisms. Recent studies suggest that the methyla…

  Authors: Xianwu Zheng, Olga Pontes, Jianhua Zhu, Daisuke Miki, Fei Zhang, Wen-Xue Li, Kei Iida, Avnish Kapoor, Craig S Pikaard, Jian-Kang Zhu

  Source: Nature. 2008 Oct 30

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• A microRNA component of the p53 tumour suppressor network.

  A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour s…

  Authors: Lin He, Xingyue He, Lee P Lim, Elisa de Stanchina, Zhenyu Xuan, Yu Liang, Wen Xue, Lars Zender, Jill Magnus, Dana Ridzon,…

  Source: Nature. 2007 Jun 28

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• IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.

  The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-kappaB signalling and cell sur…

  Authors: Mads Gyrd-Hansen, Maurice Darding, Maria Miasari, Massimo M Santoro, Lars Zender, Wen Xue, Tencho Tenev, Paula C A da Fonseca, Marketa Zvelebil, Janusz M Bujnicki,…

  Source: Nature cell biology. 2008 Nov

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• DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.

  Deletions on chromosome 8p are common in human tumors, suggesting that one or more tumor suppressor genes reside in this region. Deleted in Liver Canc…

  Authors: Wen Xue, Alexander Krasnitz, Robert Lucito, Raffaella Sordella, Linda Vanaelst, Carlos Cordon-Cardo, Stephan Singer, Florian Kuehnel, Michael Wigler, Scott Powers,…

  Source: Genes & development. 2008 Jun 1

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• Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.

  The heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through genomic approaches alone. …

  Authors: Lars Zender, Mona S Spector, Wen Xue, Peer Flemming, Carlos Cordon-Cardo, John Silke, Sheung-Tat Fan, John M Luk, Michael Wigler, Gregory J Hannon,…

  Source: Cell. 2006 Jun 30

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• Promoter methylation of glutathione S-transferase pi1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression.

  BACKGROUND: The presence of glutathione S-transferase (GST) pi1 (GSTP1) or multidrug resistance gene 1 (MDR1) promoter methylation in lung cancer was …

  Authors: Peng Gao, Xi Yang, Yu-Wen Xue, Xiao-Fang Zhang, Yan Wang, Wen-Jun Liu, Xiao-Juan Wu

  Source: Cancer. 2009 Jul 15

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• New metal-free one-pot synthesis of substituted allenes from enones.

  A new metal-free, one-pot synthesis of substituted allenes from enones was discovered for the first time, in which a tertiary amine as a base was foun…

  Authors: Meng Tang, Chun-An Fan, Fu-Min Zhang, Yong-Qiang Tu, Wen-Xue Zhang, Ai-Xia Wang

  Source: Organic letters. 2008 Dec 18

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• Effects of top excision on the potassium accumulation and expression of potassium channel genes in tobacco.

  The effects of the removal of the shoot apex of tobacco on the relative transcript levels of potassium channel genes, determined by real-time PCR, and…

  Authors: Xiao Yan Dai, Yi Rong Su, Wen Xue Wei, Jin Shui Wu, Ye Kuan Fan

  Source: Journal of experimental botany. 2009

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