1 to 10 of 149 literature results

• International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.

  The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X…

  Authors: David D Moore, Shigeaki Kato, Wen Xie, David J Mangelsdorf, Daniel R Schmidt, Rui Xiao, Steven A Kliewer

  Source: Pharmacological reviews. 2006 Dec

  View Full Text

• Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype.

  Transforming growth factor beta (TGFbeta) plays a key role in maintaining tissue homeostasis by inducing cell cycle arrest, differentiation and apopto…

  Authors: Savita Bharathy, Wen Xie, Jonathan M Yingling, Michael Reiss

  Source: Cancer research. 2008 Mar 15

  View Free Full Text

• Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.

  BACKGROUND & AIMS: Liver X receptor (LXR) is known to promote hepatic lipogenesis by activating the lipogenic transcriptional factor sterol regulatory…

  Authors: Jie Zhou, Maria Febbraio, Taira Wada, Yonggong Zhai, Ramalinga Kuruba, Jinhan He, Jung Hoon Lee, Shaheen Khadem, Songrong Ren, Song Li,…

  Source: Gastroenterology. 2008 Feb

  View Full Text

• Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies.

  Transgenic mouse models are useful to understand the function and regulation of drug-metabolizing enzymes in vivo. This article is intended to describ…

  Authors: Zhimin Ou, Min Huang, Lizi Zhao, Wen Xie

  Source: Drug metabolism reviews. 2010

  View Free Full Text

• The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor.

  Aldo-keto reductase (AKR) family 1, member 7 (AKR1B7), a member of the AKR superfamily, has been suggested to play an important role in the detoxifica…

  Authors: Ming-Jie Liu, Yuki Takahashi, Taira Wada, Jinhan He, Jie Gao, Yanan Tian, Song Li, Wen Xie

  Source: Molecular pharmacology. 2009 Sep

  View Full Text

• Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase.

  Glucocorticoids and estrogens are two classes of steroid hormones that have essential but distinct physiologic functions. Estrogens also represent a r…

  Authors: Haibiao Gong, Michael J Jarzynka, Timothy J Cole, Jung Hoon Lee, Taira Wada, Bin Zhang, Jie Gao, Wen-Chao Song, Donald B DeFranco, Shi-Yuan Cheng,…

  Source: Cancer research. 2008 Sep 15

  View Full Text

• Tissue and developmental regulation of fragile X mental retardation 1 exon 12 and 15 isoforms.

  The pre-mRNA of the fragile X mental retardation 1 gene (FMR1) is subject to exon skipping and alternative splice site selection, which can generate u…

  Authors: Wen Xie, Natalia Dolzhanskaya, Giuseppe LaFauci, Carl Dobkin, Robert B Denman

  Source: Neurobiology of disease. 2009 Jul

  View Full Text

• Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats.

  OBJECTIVE: Therapeutic hypothermia is being clinically used to reduce neurologic deficits after cardiac arrest (CA). Patients receiving hypothermia af…

  Authors: Michael A Tortorici, Ying Mu, Patrick M Kochanek, Wen Xie, Samuel M Poloyac

  Source: Critical care medicine. 2009 Jan

  View Free Full Text

• PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.

  The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of drug-metabolic enzymes and transporter…

  Authors: Bin Zhang, Wen Xie, Matthew D Krasowski

  Source: Pharmacogenomics. 2008 Nov

  View Free Full Text

• Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).

  The retinoid-related orphan receptors (RORs) and liver X receptors (LXRs) were postulated to have distinct functions. RORs play a role in tissue devel…

  Authors: Taira Wada, Hong Soon Kang, Martin Angers, Haibiao Gong, Shikha Bhatia, Shaheen Khadem, Songrong Ren, Ewa Ellis, Stephen C Strom, Anton M Jetten,…

  Source: Molecular pharmacology. 2008 Mar

  View Full Text