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The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X…
Authors: David D Moore, Shigeaki Kato, Wen Xie, David J Mangelsdorf, Daniel R Schmidt, Rui Xiao, Steven A Kliewer
Source: Pharmacological reviews. 2006 Dec
View Full TextTransforming growth factor beta (TGFbeta) plays a key role in maintaining tissue homeostasis by inducing cell cycle arrest, differentiation and apopto…
Authors: Savita Bharathy, Wen Xie, Jonathan M Yingling, Michael Reiss
Source: Cancer research. 2008 Mar 15
View Free Full TextBACKGROUND & AIMS: Liver X receptor (LXR) is known to promote hepatic lipogenesis by activating the lipogenic transcriptional factor sterol regulatory…
Authors: Jie Zhou, Maria Febbraio, Taira Wada, Yonggong Zhai, Ramalinga Kuruba, Jinhan He, Jung Hoon Lee, Shaheen Khadem, Songrong Ren, Song Li,…
Source: Gastroenterology. 2008 Feb
View Full TextTransgenic mouse models are useful to understand the function and regulation of drug-metabolizing enzymes in vivo. This article is intended to describ…
Authors: Zhimin Ou, Min Huang, Lizi Zhao, Wen Xie
Source: Drug metabolism reviews. 2010
View Free Full TextAldo-keto reductase (AKR) family 1, member 7 (AKR1B7), a member of the AKR superfamily, has been suggested to play an important role in the detoxifica…
Authors: Ming-Jie Liu, Yuki Takahashi, Taira Wada, Jinhan He, Jie Gao, Yanan Tian, Song Li, Wen Xie
Source: Molecular pharmacology. 2009 Sep
View Full TextGlucocorticoids and estrogens are two classes of steroid hormones that have essential but distinct physiologic functions. Estrogens also represent a r…
Authors: Haibiao Gong, Michael J Jarzynka, Timothy J Cole, Jung Hoon Lee, Taira Wada, Bin Zhang, Jie Gao, Wen-Chao Song, Donald B DeFranco, Shi-Yuan Cheng,…
Source: Cancer research. 2008 Sep 15
View Full TextThe pre-mRNA of the fragile X mental retardation 1 gene (FMR1) is subject to exon skipping and alternative splice site selection, which can generate u…
Authors: Wen Xie, Natalia Dolzhanskaya, Giuseppe LaFauci, Carl Dobkin, Robert B Denman
Source: Neurobiology of disease. 2009 Jul
View Full TextOBJECTIVE: Therapeutic hypothermia is being clinically used to reduce neurologic deficits after cardiac arrest (CA). Patients receiving hypothermia af…
Authors: Michael A Tortorici, Ying Mu, Patrick M Kochanek, Wen Xie, Samuel M Poloyac
Source: Critical care medicine. 2009 Jan
View Free Full TextThe pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of drug-metabolic enzymes and transporter…
Authors: Bin Zhang, Wen Xie, Matthew D Krasowski
Source: Pharmacogenomics. 2008 Nov
View Free Full TextThe retinoid-related orphan receptors (RORs) and liver X receptors (LXRs) were postulated to have distinct functions. RORs play a role in tissue devel…
Authors: Taira Wada, Hong Soon Kang, Martin Angers, Haibiao Gong, Shikha Bhatia, Shaheen Khadem, Songrong Ren, Ewa Ellis, Stephen C Strom, Anton M Jetten,…
Source: Molecular pharmacology. 2008 Mar
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