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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in commo…
Authors: Wellcome Trust Case Control Consortium
Source: Nature. 2007 Jun 7
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Genome-wide association study identifies five loci associated with lung function.
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We test…
Authors: Emmanouela Repapi, Ian Sayers, Louise V Wain, Paul R Burton, Toby Johnson, Ma'en Obeidat, Jing Hua Zhao, Adaikalavan Ramasamy, Guangju Zhai, Veronique Vitart,…
Source: Nature genetics. 2010 Jan
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Rheumatoid arthritis association at 6q23.
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x…
Authors: Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce,…
Source: Nature genetics. 2007 Dec
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Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of…
Authors: Anne Barton, Wendy Thomson, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Darren Plant, Laura J Gibbons, Wellcome Trust Case Control Consortium, YEAR Consortium,…
Source: Nature genetics. 2008 Oct
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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four n…
Authors: Miles Parkes, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Carl A Anderson, Sheila A Fisher, Roland G Roberts, Elaine R Nimmo, Fraser R Cummings, Dianne Soars,…
Source: Nature genetics. 2007 Jul
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Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we…
Authors: UK IBD Genetics Consortium, Jeffrey C Barrett, James C Lee, Charles W Lees, Natalie J Prescott, Carl A Anderson, Anne Phillips, Emma Wesley, Kirstie Parnell, Hu Zhang,…
Source: Nature genetics. 2009 Dec
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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmu…
Authors: John A Todd, Neil M Walker, Jason D Cooper, Deborah J Smyth, Kate Downes, Vincent Plagnol, Rebecca Bailey, Sergey Nejentsev, Sarah F Field, Felicity Payne,…
Source: Nature genetics. 2007 Jul
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New susceptibility locus for coronary artery disease on chromosome 3q22.3.
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replica…
Authors: Jeanette Erdmann, Anika Grosshennig, Peter S Braund, Inke R König, Christian Hengstenberg, Alistair S Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David-Alexandre Trégouët,…
Source: Nature genetics. 2009 Mar
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Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype asso…
Authors: David-Alexandre Trégouët, Inke R König, Jeanette Erdmann, Alexandru Munteanu, Peter S Braund, Alistair S Hall, Anika Grosshennig, Patrick Linsel-Nitschke, Claire Perret, Maylis DeSuremain,…
Source: Nature genetics. 2009 Mar
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Common variants near TERC are associated with mean telomere length.
We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals.…
Authors: Veryan Codd, Massimo Mangino, Pim van der Harst, Peter S Braund, Michael Kaiser, Alan J Beveridge, Suzanne Rafelt, Jasbir Moore, Chris Nelson, Nicole Soranzo,…
Source: Nature genetics. 2010 Mar
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