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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in commo…
Authors: Wellcome Trust Case Control Consortium
Source: Nature. 2007 Jun 7
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Genome-wide association study identifies eight loci associated with blood pressure.
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influenci…
Authors: Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D Tobin, Murielle Bochud, Lachlan Coin, Samer S Najjar, Jing Hua Zhao, Simon C Heath, Susana Eyheramendy,…
Source: Nature genetics. 2009 May 10
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Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we…
Authors: The UK IBD Genetics Consortium & the Wellcome Trust Case Control Consortium 2, Jeffrey C Barrett, James C Lee, Charles W Lees, Natalie J Prescott, Carl A Anderson, Anne Phillips, Emma Wesley, Kirstie Parnell, Hu Zhang,…
Source: Nature genetics. 2009 Nov 15
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Rheumatoid arthritis association at 6q23.
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x…
Authors: Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce,…
Source: Nature genetics. 2007 Dec
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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four n…
Authors: Miles Parkes, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Carl A Anderson, Sheila A Fisher, Roland G Roberts, Elaine R Nimmo, Fraser R Cummings, Dianne Soars,…
Source: Nature genetics. 2007 Jul
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Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of…
Authors: Anne Barton, Wendy Thomson, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Darren Plant, Laura J Gibbons, Wellcome Trust Case Control Consortium, YEAR Consortium,…
Source: Nature genetics. 2008 Oct
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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmu…
Authors: John A Todd, Neil M Walker, Jason D Cooper, Deborah J Smyth, Kate Downes, Vincent Plagnol, Rebecca Bailey, Sergey Nejentsev, Sarah F Field, Felicity Payne,…
Source: Nature genetics. 2007 Jul
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New susceptibility locus for coronary artery disease on chromosome 3q22.3.
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replica…
Authors: Jeanette Erdmann, Anika Grosshennig, Peter S Braund, Inke R König, Christian Hengstenberg, Alistair S Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David-Alexandre Trégouët,…
Source: Nature genetics. 2009 Mar
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Origins and functional impact of copy number variation in the human genome.
Structural variations of DNA greater than 1 kilobase in size account for most bases that vary among human genomes, but are still relatively under-asce…
Authors: Donald F Conrad, Dalila Pinto, Richard Redon, Lars Feuk, Omer Gokcumen, Yujun Zhang, Jan Aerts, T Daniel Andrews, Chris Barnes, Peter Campbell,…
Source: Nature. 2009 Oct 7
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Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype asso…
Authors: David-Alexandre Trégouët, Inke R König, Jeanette Erdmann, Alexandru Munteanu, Peter S Braund, Alistair S Hall, Anika Grosshennig, Patrick Linsel-Nitschke, Claire Perret, Maylis DeSuremain,…
Source: Nature genetics. 2009 Mar
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